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Dear colleagues, This Special Issue aims to publish new and innovative research that could demonstrate the therapeutic potential of natural health products, through relevant in vitro and/or in vivo biological activities, to prevent or alleviate degenerative diseases. The interaction of natural health products with human microbiota represents an essential aspect, because it could modulate the microbial pattern and alleviate more of a chronic disease’s effects in the case of type 2 diabetes, cardiovascular dysfunctions, neurodegenerative diseases, and inflammatory colon pathologies. Additionally, you are invited to send research based on the effect of different extracts or functional foods used in degenerative pathologies and interactions with human microbiota. We aim to identify new data on in vitro/in vivo research that could demonstrate the bioavailability of natural compounds and the relationship with antioxidant/antimicrobial capacity. Modulated microbiota aspects are expected to be published based on the interaction with natural compounds, natural sweeteners, or other molecules that influence the colon health status.

Technology: general issues --- Biotechnology --- in vitro callus --- cell suspension and root cultures --- biologically active substances --- ecdysteroids --- HPLC --- 1H NMR spectra --- Rhaponticum carthamoides --- Chaga --- medicinal fungi --- biomass yield --- mathematical modeling --- response surface methodology --- bioreactor culture --- mycelium --- antioxidant activity --- gamma irradiation --- Fomes fomentarius --- mushroom --- DPPH --- flavonoids --- polyphenols --- urinary infection --- in vitro --- Escherichia coli --- antimicrobial --- yellow onion skins --- extraction --- multifunctional ingredients --- Ficus carica L. --- ultrasonic enzyme co-assisted --- aqueous two-phase extraction --- UPLC-QTOF-MS/MS --- identification --- lactic acid fermentation --- betalain --- carotenoids --- red pepper --- beetroot --- carrot --- drying --- heat treatment --- seaweeds --- bioactive compounds --- food safety --- consumer health --- Cannabis sativa L. --- cannabinoids --- hemp oil --- UHPLC-PDA --- validation --- Cnidoscolus aconitifolius --- inflammation --- croton oil --- HL-60 --- phenols --- differentiation --- apoptosis --- transcriptome --- natural products --- bacteria --- downstream processing --- antibiotics --- isolation --- secondary metabolites --- pharmacognosy --- bioprospecting --- U. lactuca --- non-toxic solvents --- phenolics --- uropathogenic --- herbal medicines --- plant extract --- bioactive molecules --- in vitro callus --- cell suspension and root cultures --- biologically active substances --- ecdysteroids --- HPLC --- 1H NMR spectra --- Rhaponticum carthamoides --- Chaga --- medicinal fungi --- biomass yield --- mathematical modeling --- response surface methodology --- bioreactor culture --- mycelium --- antioxidant activity --- gamma irradiation --- Fomes fomentarius --- mushroom --- DPPH --- flavonoids --- polyphenols --- urinary infection --- in vitro --- Escherichia coli --- antimicrobial --- yellow onion skins --- extraction --- multifunctional ingredients --- Ficus carica L. --- ultrasonic enzyme co-assisted --- aqueous two-phase extraction --- UPLC-QTOF-MS/MS --- identification --- lactic acid fermentation --- betalain --- carotenoids --- red pepper --- beetroot --- carrot --- drying --- heat treatment --- seaweeds --- bioactive compounds --- food safety --- consumer health --- Cannabis sativa L. --- cannabinoids --- hemp oil --- UHPLC-PDA --- validation --- Cnidoscolus aconitifolius --- inflammation --- croton oil --- HL-60 --- phenols --- differentiation --- apoptosis --- transcriptome --- natural products --- bacteria --- downstream processing --- antibiotics --- isolation --- secondary metabolites --- pharmacognosy --- bioprospecting --- U. lactuca --- non-toxic solvents --- phenolics --- uropathogenic --- herbal medicines --- plant extract --- bioactive molecules

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It is our pleasure to present this Special Issue of Pharmaceuticals, entitled “Applications of Liquid Chromatography in Analysis of Pharmaceuticals and Natural Products”. Plants produce a wide range of phytochemicals, which are secondary metabolites that confirm their identity and are used for the production of natural pharmaceuticals, among other things. The use of modern chromatographic techniques allows accurate quantitative and qualitative identification of the above-mentioned phytochemicals and their natural products. Liquid chromatography is one of the most efficient and robust specific techniques, due to the merits of convenience and strong separation ability, as well as a wide range of material applications for identification. Liquid chromatography is widely used for the analysis of plants, nutraceuticals, pharmaceuticals, natural product quality control, or quantitative determination of bioactive compounds. The most commonly used for the identification of different plant material and pharmaceuticals are the ultra- and high-performance liquid chromatography with UV-VIS, fluorescence, diode array, and equipped with mass spectrometry or tandem mass spectrometry detection methods. Therefore, for this Special Issue, we published works concerning the latest scientific news, insights, and advances in the field of innovation and applications of liquid chromatography in the analysis of phytochemicals and natural products.

Research & information: general --- Biology, life sciences --- Food & society --- in vitro biological activity --- bioactive compounds --- morphological parts --- medical plant --- Fragaria viridis --- creamy strawberry --- ellagitannins --- HPLC --- mass spectrometry --- fruit ripening --- antioxidant potential --- bisphenol A --- high-performance liquid chromatography --- ionic liquid --- dispersive liquid–liquid microextraction --- extraction kinetic studies --- tenofovir --- creatinine --- HPLC-UV --- hepatitis B virus --- human immunodeficiency virus --- anatoxin-a(s) --- neurotoxins --- cyanobacteria poisoning --- bio-accessibility --- isothiazolinones --- parabens --- cosmetics --- SPE --- UHPLC/DAD --- Gardenia jasminoides Ellis --- anti-diabetic activity --- LC-MS/MS --- GC-MS --- anti-oxidant --- Ficus glumosa --- polyphenols --- HPLC-ESI-MS/MS --- antiproliferative --- antioxidant --- Ayurveda --- Divya-Swasari-Vati --- herbal medicine --- UPLC/QToF MS --- validation --- Allium cepa L. --- Box–Behnken --- flavonoids --- quercetin glycosides --- liquid chromatography --- multiresponse optimization --- onion --- phenolic compounds --- UHPLC --- HPLC-MS/MS --- steroidal hormones --- anti-doping --- bovine blood --- equine blood --- natural products --- plant materials --- dietary supplements --- terpenes --- capillary liquid chromatography --- steroids --- skin permeability --- thin layer chromatography --- calculated physicochemical descriptors --- topical formulation --- anti-cellulite --- cosmetic --- monoterpenoids --- accelerated stability --- F0 concept --- steam sterilization --- sterilization safety --- glucose degradation products --- α-dicarbonyl compounds --- derivatization --- tandem mass spectrometry --- Geobacillus stearothermophilus --- paracetamol --- accuracy profile --- 3D printed --- formulation --- biorelevant media --- in vitro biological activity --- bioactive compounds --- morphological parts --- medical plant --- Fragaria viridis --- creamy strawberry --- ellagitannins --- HPLC --- mass spectrometry --- fruit ripening --- antioxidant potential --- bisphenol A --- high-performance liquid chromatography --- ionic liquid --- dispersive liquid–liquid microextraction --- extraction kinetic studies --- tenofovir --- creatinine --- HPLC-UV --- hepatitis B virus --- human immunodeficiency virus --- anatoxin-a(s) --- neurotoxins --- cyanobacteria poisoning --- bio-accessibility --- isothiazolinones --- parabens --- cosmetics --- SPE --- UHPLC/DAD --- Gardenia jasminoides Ellis --- anti-diabetic activity --- LC-MS/MS --- GC-MS --- anti-oxidant --- Ficus glumosa --- polyphenols --- HPLC-ESI-MS/MS --- antiproliferative --- antioxidant --- Ayurveda --- Divya-Swasari-Vati --- herbal medicine --- UPLC/QToF MS --- validation --- Allium cepa L. --- Box–Behnken --- flavonoids --- quercetin glycosides --- liquid chromatography --- multiresponse optimization --- onion --- phenolic compounds --- UHPLC --- HPLC-MS/MS --- steroidal hormones --- anti-doping --- bovine blood --- equine blood --- natural products --- plant materials --- dietary supplements --- terpenes --- capillary liquid chromatography --- steroids --- skin permeability --- thin layer chromatography --- calculated physicochemical descriptors --- topical formulation --- anti-cellulite --- cosmetic --- monoterpenoids --- accelerated stability --- F0 concept --- steam sterilization --- sterilization safety --- glucose degradation products --- α-dicarbonyl compounds --- derivatization --- tandem mass spectrometry --- Geobacillus stearothermophilus --- paracetamol --- accuracy profile --- 3D printed --- formulation --- biorelevant media

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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives.Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today.This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Scorzonera --- capsaicinoids --- artificial neural network --- cerebral ischemia reperfusion injury --- antioxidant activity --- quality evaluation --- chemometrics --- secondary metabolites --- identification --- antioxidant capacity --- Moroccan region --- volatile compounds --- HPLC-Q-Exactive-Orbitrap-MS --- quantitative analysis --- amino acids content --- HPLC-ELSD --- antioxidant --- autophagy --- quantification --- sugars --- 1-triacontanol --- hemp seed oil --- Alzheimer’s disease --- macrodiolides --- extraction --- recycling preparative high performance liquid chromatography --- HPLC methods --- GC-MS --- Myristica fragrans --- Rossa da inverno sel. Rojo Duro onion cultivar --- fruit powders --- decursin --- food traceability --- ionic liquids --- separation optimisation --- Spondias spp. --- C-glycosylflavone --- wine --- UPLC-MS --- scutellarein --- saffron --- carotenoids --- red cabbage --- hydrodistillation --- Ginkgo biloba Extract (GBE) --- gas chromatography --- organic acids --- olive leaves --- crocins --- CBD oil --- Bolbostemma paniculatum --- UPLC-ESI-MS/MS --- geographical origin --- HPLC --- traditional Chinese medicine decoction --- liquid chromatography --- bioactive natural compounds --- Podospermum --- metabolic profiling --- SPME-GC/MS --- LTQ-Orbitrap --- oral administration --- UPLC --- bioactive compounds --- Erigeron breviscapus extract --- terrain conditions --- nutmeg --- antibacterial activity --- method validation --- ShenFu prescription decoction --- chili --- decursinol angelate --- statistical evaluations --- stereoselective and simultaneous analysis --- curcuminoids --- Talaromyces pinophilus --- talarodiolide --- HPLC-Q-TOF-MS/MS --- Olea europaea L. --- triterpenes --- chromatogram-bioactivity correlation --- essential oil --- stability --- Staphylococcus aureus --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- endothelial function --- anthocyanins --- HPLC analysis --- liquid chromatography-mass spectrometry --- nodakenin --- turmerone --- UHPLC-MS/MS --- Quercus acuta leaf --- Curcuma longa --- UHPLC analysis --- ginseng berry extract --- geographical variation --- qualitative analysis --- Sorbus --- free radical-scavenging --- ginsenosides --- flavonoids --- biostimulant --- GC/MS --- terpenes --- aleuritolic acid --- phenolic compounds --- apoptosis --- response surface methodology --- phenolic acids --- pharmacokinetics --- mass spectrometry --- scutellarin --- multivariate statistical analysis --- phenolics --- MODDE experimental design --- proanthocyanidins --- UFLC-QQQ-MS --- rice --- cannabidiol --- odor-activity values --- UPLC-QTOF-MS --- turmeric --- decursinol --- Scorzonera --- capsaicinoids --- artificial neural network --- cerebral ischemia reperfusion injury --- antioxidant activity --- quality evaluation --- chemometrics --- secondary metabolites --- identification --- antioxidant capacity --- Moroccan region --- volatile compounds --- HPLC-Q-Exactive-Orbitrap-MS --- quantitative analysis --- amino acids content --- HPLC-ELSD --- antioxidant --- autophagy --- quantification --- sugars --- 1-triacontanol --- hemp seed oil --- Alzheimer’s disease --- macrodiolides --- extraction --- recycling preparative high performance liquid chromatography --- HPLC methods --- GC-MS --- Myristica fragrans --- Rossa da inverno sel. Rojo Duro onion cultivar --- fruit powders --- decursin --- food traceability --- ionic liquids --- separation optimisation --- Spondias spp. --- C-glycosylflavone --- wine --- UPLC-MS --- scutellarein --- saffron --- carotenoids --- red cabbage --- hydrodistillation --- Ginkgo biloba Extract (GBE) --- gas chromatography --- organic acids --- olive leaves --- crocins --- CBD oil --- Bolbostemma paniculatum --- UPLC-ESI-MS/MS --- geographical origin --- HPLC --- traditional Chinese medicine decoction --- liquid chromatography --- bioactive natural compounds --- Podospermum --- metabolic profiling --- SPME-GC/MS --- LTQ-Orbitrap --- oral administration --- UPLC --- bioactive compounds --- Erigeron breviscapus extract --- terrain conditions --- nutmeg --- antibacterial activity --- method validation --- ShenFu prescription decoction --- chili --- decursinol angelate --- statistical evaluations --- stereoselective and simultaneous analysis --- curcuminoids --- Talaromyces pinophilus --- talarodiolide --- HPLC-Q-TOF-MS/MS --- Olea europaea L. --- triterpenes --- chromatogram-bioactivity correlation --- essential oil --- stability --- Staphylococcus aureus --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- endothelial function --- anthocyanins --- HPLC analysis --- liquid chromatography-mass spectrometry --- nodakenin --- turmerone --- UHPLC-MS/MS --- Quercus acuta leaf --- Curcuma longa --- UHPLC analysis --- ginseng berry extract --- geographical variation --- qualitative analysis --- Sorbus --- free radical-scavenging --- ginsenosides --- flavonoids --- biostimulant --- GC/MS --- terpenes --- aleuritolic acid --- phenolic compounds --- apoptosis --- response surface methodology --- phenolic acids --- pharmacokinetics --- mass spectrometry --- scutellarin --- multivariate statistical analysis --- phenolics --- MODDE experimental design --- proanthocyanidins --- UFLC-QQQ-MS --- rice --- cannabidiol --- odor-activity values --- UPLC-QTOF-MS --- turmeric --- decursinol