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This dissertation explores the genetic mechanisms involved in terminal cell fate specification within the central nervous system (CNS) of Drosophila melanogaster. It focuses on the role of transcription factors in determining the fate of neuronal subtypes, particularly within the embryonic ventral nerve cord. The research highlights the Nplp1 neurons and their specification through a cascade of terminal selectors influenced by spatial-temporal cues. The study employs genetic and molecular techniques to investigate the regulatory networks and the role of cis-regulatory modules. The findings contribute to understanding how similar cell types are specified across different CNS regions, with implications for broader biological processes in both Drosophila and mammals. This work is intended for researchers in developmental biology and genetics.

Neurogenetics. --- Transcription factors.

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TRANSCRIPTION FACTORS --- THYROID GLAND --- TRANSCRIPTION FACTORS --- THYROID GLAND

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RNA POLYMERASES --- TRANSCRIPTION FACTORS --- RNA POLYMERASES --- TRANSCRIPTION FACTORS

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This dissertation by Madhanagopal focuses on the structural insights into protein-protein interactions that regulate transcription initiation and related cellular processes. The study examines the role of RNA polymerase II in eukaryotic transcription, emphasizing the formation of the Pre-Initiation Complex (PIC) and the involvement of TBP and TAF1 in this process. It also explores the ubiquitin-mediated post-translational modification of proteins, particularly through the E3 ligase TRIM21, which is significant in autoimmune pathogenesis. The work further investigates the MexR protein mutation and its implications for multidrug resistance. Using a combination of crystallography, NMR, and SAXS, this research provides a detailed molecular understanding that is crucial for structure-based drug design, targeting a scientific audience involved in molecular biology and biotechnology.

Protein-protein interactions. --- Transcription factors.

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Forkhead Transcription Factors. --- Wnt Signaling Pathway. --- Neoplasms.