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This book provides dental professionals with a clear understanding of current clinical and scientific knowledge on the various aspects of pulp treatment for both primary and young permanent teeth. Diagnostic parameters are clearly presented, along with step-by-step descriptions of clinical procedures, including indirect and direct pulp treatments, pulpotomy, and pulpectomy. The rationale for the materials used in each technique and their individual merits and disadvantages are examined in detail. In the case of pulpotomy, all the materials used since the introduction of this treatment modality are discussed (e.g., formocresol, glutaraldehyde, ferric sulfate, and MTA) and the roles of sodium hypochlorite, electrofulguration, and laser therapy are elucidated. Special attention is devoted to pulpectomy and root canal treatment, with consideration of debriding and obturation techniques, rinsing solutions, and root-filling pastes. A further individual chapter is dedicated to restorations of teeth treated with the different types of pulp therapy. The various conservative treatment modalities are also presented, including specific treatments for immature nonvital permanent teeth. The concluding chapter looks to the future and the potential value of stem cells in pulp therapy.

Stomatology --- stamcellen --- stomatologie --- Dentistry. --- Dental surgery --- Odontology --- Surgery, Dental --- Medicine --- Oral medicine --- Teeth

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Since the publication of the sixth edition of this benchmark text, numerous advances in the field have been made - particularly in stem cells, 3D culture, scale-up, STR profiling, and culture of specialized cells. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition is the updated version of this benchmark text, addressing these recent developments in the field as well as the basic skills and protocols. This eagerly awaited edition reviews the increasing diversity of the applications of cell culture and the proliferation of specialized techniques, and provides an introduction to new subtopics in mini-reviews. New features also include a new chapter on cell line authentication with a review of the major issues and appropriate protocols including DNA profiling and barcoding, as well as some new specialized protocols. Because of the continuing expansion of cell culture, and to keep the bulk of the book to a reasonable size, some specialized protocols are presented as supplementary material online. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition provides the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells. This text is an indispensable resource for those in or entering the field, including academic research scientists, clinical and biopharmaceutical researchers, undergraduate and graduate students, cell and molecular biology and genetics lab managers, trainees and technicians.

Biological techniques --- histologie --- dierlijke cellenkweek --- Zoohistology. Zoocytology --- Cells, Cultured --- Culture Techniques --- methods --- Biologie animale --- Cellules --- Cultures et milieux de culture --- Technique --- Cells, Cultured. --- Culture Techniques. --- Biologie animale. --- Technique. --- stamcellen --- klonen --- Tissue culture --- Cell culture --- Cell culture. --- Tissue culture.

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This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes. .

Histology. Cytology --- Biology --- Pharmacology. Therapy --- Pathology of the metabolism --- Pathological endocrinology --- Human medicine --- Manufacturing technologies --- farmacologie --- stamcellen --- biologie --- geneeskunde --- diabetes mellitus --- stamceltransplantatie --- histologie --- Stem cells. --- Regenerative medicine. --- Tissue engineering. --- Diabetes. --- Stem Cells. --- Regenerative Medicine/Tissue Engineering.

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This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.

Genetics --- Histology. Cytology --- Human genetics --- genomen (geneeskunde) --- medische genetica --- stamcellen --- genetica --- stamceltransplantatie --- Human genetics. --- Microbial genetics. --- Microbial genomics. --- Stem cells. --- Human Genetics. --- Microbial Genetics and Genomics. --- Stem Cells. --- Genomics --- Microbial genetics --- Microorganisms --- Microbiology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Heredity, Human --- Human biology --- Physical anthropology

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"As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know," introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens"--Provided by publisher.

Basic Sciences. Molecular Biology --- Cells. --- Molecular biology. --- Molecular Biology (General). --- Histology. Cytology --- Molecular biology --- stamcellen --- bio-energie --- kernenergie --- moleculaire biologie --- Cytology. --- Molecular Biology --- Molecular Biology. --- General. --- Cytology --- Cells --- Cell Biology --- Cytologie --- Biologie moléculaire --- Celbiologie --- Moleculaire biologie --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- Cell --- 576.32/.36 --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology