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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Paediatric medicine --- brain tumors --- pediatric neuro-oncology --- children --- central nervous system tumors --- pediatric oncology --- brain tumors --- pediatric neuro-oncology --- children --- central nervous system tumors --- pediatric oncology

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Pediatric cancer develops in 1 to 500 children. Typically, the type of cancers that develop in children is different than those that develop in adults, in that they are often the result of a DNA mutation rather than environmental or lifestyle risk factors. Leukemia, brain and central nervous system tumors, and neuroblastomas are the most common cancer types in child populations. Children tend to respond better to anticancer treatments, including chemotherapy and radiation. However, long-term side effects are common in children, often requiring follow-up care and lifestyle intervention for the rest of their lives. The percentage of 5-year survivors was over 50% for the most common cancers. This suggests that a majority of cancers in this population are highly survivable. As such, research should focus on aspects of survivorship for these individuals. This book will explore issues related to pediatric cancer and their associated treatments.

Cancer Survivors --- psychology. --- Cancer patients --- Cancer survivors --- Survivors, Cancer --- Medicine --- Pediatrics --- Pediatric Oncology --- Health Sciences

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Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.

Oncology --- Cancer in children --- targeted therapy --- Translational research --- Ewing sarcoma --- Sarcoma --- pediatric oncology --- Osteosarcoma --- Immunotherapy --- bone tumor --- Rhabdomyosarcoma --- epithelioid sarcoma --- Research. --- Treatment. --- targeted therapy --- Translational research --- Ewing sarcoma --- Sarcoma --- pediatric oncology --- Osteosarcoma --- Immunotherapy --- bone tumor --- Rhabdomyosarcoma --- epithelioid sarcoma

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Oncology --- Cancer Epidemiology and Prevention --- Cancer Genetics --- Cancer Metabolism --- Gastrointestinal Cancers --- Radiation Oncology --- Pediatric Oncology --- Surgical Oncology --- clinical trials --- consensus --- guidelines --- Cancer Epidemiology and Prevention --- Cancer Genetics --- Cancer Metabolism --- Gastrointestinal Cancers --- Radiation Oncology --- Pediatric Oncology --- Surgical Oncology --- clinical trials --- consensus --- guidelines

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Beginning with the scientific basis of tumors, this book provides up-to-date information on epidemiology, cytogenetics, and molecular biology, before examining current treatments for the full range of pediatric tumors. Integration of surgery, neoadjuvant and adjuvant chemotherapy, and radiation therapy is a dominant theme. In addition, chapters on supportive care, palliative care, and the role of parents’ associations reflect the book's holistic approach to treating children with cancer. The  Surgery of Childhood Tumors is written by world-renowned international authorities on pediatric cancer from major children's cancer groups in the UK, Europe, and the US. Contributors discuss geographical variations in treatment for each type of tumor. Excellent full-color pictures and line drawings illustrate all aspects of managing childhood tumors, including details of operative techniques which are neglected in many other texts. This comprehensive book provides a contemporary approach for pediatric, general, and urological surgeons dealing with childhood tumors. Since the second edition, the book has been significantly expanded and updated in order to encompass the very latest developments and strategies in pediatric surgical oncology.

Medicine. --- Pediatric surgery. --- Surgical oncology. --- Medicine & Public Health. --- Pediatric Surgery. --- Surgical Oncology. --- Tumors --- Tumors in children --- Surgery. --- Pediatric oncology --- Children --- Diseases --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Surgery, Primitive --- Medicine --- Excision --- Treatment --- Pediatric surgery --- Surgery, Pediatric