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The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license.

Oxygen --- Tissue respiration. --- Physiological transport. --- Oxidation, Physiological --- Respiration --- Tissue metabolism --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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In Free Radical and Antioxidant Protocols, seventy-six leading international authorities describe cutting-edge methodologies for quantifying free radical and antioxidant analytes in tissue and body fluids using experimental models and in vitro procedures. These user-friendly and easily reproducible techniques cover the essential tasks, including radical generating systems, direct measurement or trapping of reactive radical species and acute-phase proteins, and measurement of metabolic intermediates derived from the oxidation of lipids, proteins, and nucleic acids. There are also methods for the determination of vitamin, enzymatic, and water-soluble antioxidants, as well as of essential micronutrients and cofactors. The techniques take advantage of new instrumentation-probes, photon counting, chemiluminescence, and caged compounds, with an emphasis on HPLC-and are adaptable to a wide range of applications. Free Radical and Antioxidant Protocols provides state-of-the-art methodology and biotechnology in a convenient format for both academic and corporate biomedical scientists. The detailed, laboratory-tested free-radical assays, many of them presented here for the first time, will illuminate the study of both primary and secondary oxidative stress and contribute significantly to our understanding of the many disorders associated with this process.

Analytical biochemistry --- Free radicals (Chemistry) --- Antioxidants --- Oxidation, Physiological --- Stress (Physiology) --- Pathophysiology --- Laboratory manuals. --- Physiological effect --- Research --- Laboratory manuals --- Enzymes --- Oxygène --- Oxygen --- Consommation d'oxygène --- Oxygen consumption --- Métabolisme des lipides --- Lipid metabolism --- Oxydation --- Oxidation --- Life sciences. --- Biochemistry. --- Life Sciences. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Biosciences --- Sciences, Life --- Science --- Composition --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Chemical inhibitors --- Physiological stress --- Tension (Physiology) --- Adaptation (Biology) --- Radicals (Chemistry) --- Free radical reactions --- Free radicals (Chemistry) - Pathophysiology - Laboratory manuals --- Antioxidants - Physiological effect - Laboratory manuals --- Oxidation, Physiological - Laboratory manuals --- Stress (Physiology) - Research - Laboratory manuals

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Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Oxidation, Physiological. --- Oxidation. --- Autoxidation --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Toxicology. --- Chemistry. --- Cytology. --- Pharmacology/Toxicology. --- Chemistry/Food Science, general. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Physical sciences --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Cell biology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Chemistry --- Engineering --- Life Sciences --- Biochemistry --- General and Others --- Biotechnology --- Enzymes --- Enzymology --- Oxidation, Physiological --- Research --- enzymen --- Oxidation-Reduction --- Enzymology. --- Redox --- Oxidation Reduction --- Biocatalysts --- Biocatalyst --- Enzyme --- Molecular Mechanisms of Pharmacological Action --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Research.

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This book offers comprehensive information on the main techniques for measuring water-oxidation-catalyst (WOC) performance, with a particular focus on the combined use of sacrificial oxidants and dyes within closed-batch reactors. It provides an overview of the latest advances in the synthesis of more efficient WOCs, followed by an analysis of the requirements for sustainable energy production. Readers will find a detailed description of the reaction mechanism used in catalyst assessment systems, which reveals the benefits and limitations of the most common sacrificial oxidant/dye pair. Experimental techniques including electrochemical methods for characterizing novel and non-photoactive WOCs are also described. Throughout the book, various manganese oxides are used as examples of the techniques reviewed or proposed systems. Cost considerations and technological perspectives of the scale-up of solar-driven hydrogen production are also addressed. Lastly, the book presents lessons learned from the implementation of a large-scale real-world device.

Oxidation, Physiological. --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Materials science. --- Force and energy. --- Catalysis. --- Renewable energy sources. --- Chemistry. --- Energy Materials. --- Renewable and Green Energy. --- Electrochemistry. --- Physical sciences --- Alternate energy sources --- Alternative energy sources --- Energy sources, Renewable --- Sustainable energy sources --- Power resources --- Renewable natural resources --- Agriculture and energy --- Activation (Chemistry) --- Chemistry, Physical and theoretical --- Surface chemistry --- Conservation of energy --- Correlation of forces --- Energy --- Physics --- Dynamics --- Material science --- Renewable energy resources.