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Skin --- Mosaicism. --- Skin Neoplasms. --- Skin Diseases. --- Nevus. --- Diseases.
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CHROMOSOMES, HUMAN, PAIR 21 --- CHROMOSOME MAPPING --- MELANOMA --- DYSPALSTIC NEVUS SYNDROME --- GENETICS --- GENETICS --- CHROMOSOMES, HUMAN, PAIR 21 --- CHROMOSOME MAPPING --- MELANOMA --- DYSPALSTIC NEVUS SYNDROME --- GENETICS --- GENETICS
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Paul Gerson Unna’s “Abtropfung” theory that nevi develop through migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration based on newly acquired observations from histopathology and studies of embryogenesis. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of the aforementioned theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
Medicine. --- Nevus -- Physiopathology. --- Skin neoplasms -- Physiopathology. --- Mole (Dermatology) --- Skin Diseases --- Neoplasms by Site --- Nevi and Melanomas --- Neoplasms by Histologic Type --- Neoplasms --- Skin and Connective Tissue Diseases --- Diseases --- Skin Neoplasms --- Nevus --- Medicine --- Health & Biological Sciences --- Dermatology --- Skin --- Melanoma. --- Diseases. --- Moles (Dermatology) --- Naevus --- Malignant melanoma --- Melanocytic tumor --- Cutaneous diseases --- Dermatoses --- Dermatology. --- Oncology. --- Medicine & Public Health. --- Cancer --- Neuroendocrine tumors --- Oncology . --- Tumors
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The histopathologic interpretation of melanocytic neoplasms is probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions that histopathologists might encounter. Each case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist both general pathologists and dermatopathologists in making an accurate diagnosis applicable to their daily practice, and one that can be understood by clinicians. They achieve this by providing criteria that can serve as a sound basis for an unequivocal diagnosis in most cases. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.
Melanoma --- Mole (Dermatology) --- Cytodiagnosis. --- Histopathology. --- Malignant melanoma --- Melanocytic tumor --- Moles (Dermatology) --- Naevus --- Nevus --- Medicine. --- Dermatology. --- Oncology. --- Pathology. --- Medicine & Public Health. --- Skin --- Cancer --- Neuroendocrine tumors --- Oncology . --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive
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Highly acclaimed and considered the leading reference in the field, Pathology of Melanocytic Nevi and Melanoma has once again been fully revised, updated, and expanded to reflect the most recent advances and techniques in the field of melanoma pathology. New chapters on mucosal melanoma, ocular melanoma, and pigmented lesions of the nail apparatus have been included in this new edition. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated with the aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, and outstanding characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Pathology of Melanocytic Nevi and Melanoma is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today.
Dermatology. --- Medicine. --- Melanoma -- Pathophysiology. --- Melanoma. --- Oncology. --- Pathology. --- Skin Diseases --- Neoplasms by Site --- Nevi and Melanomas --- Neuroendocrine Tumors --- Epithelial Cells --- Neoplasms by Histologic Type --- Neuroectodermal Tumors --- Cells --- Neoplasms --- Skin and Connective Tissue Diseases --- Diseases --- Anatomy --- Neoplasms, Nerve Tissue --- Neoplasms, Germ Cell and Embryonal --- Skin Neoplasms --- Melanoma --- Melanocytes --- Nevus --- Medicine --- Health & Biological Sciences --- Oncology --- Pathophysiology. --- Malignant melanoma --- Melanocytic tumor --- Medicine & Public Health. --- Cancer --- Neuroendocrine tumors --- Oncology . --- Tumors --- Skin --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive
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Pathology of Challenging Melanocytic Neoplasms offers a dynamic text where readers will encounter a broad spectrum of challenging melanocytic lesions, both benign and malignant, and acquire a solid, working knowledge that they can immediately apply to daily diagnosis. The volume emphasizes the practical application of basic morphologic principles, immunohistochemistry, and ancillary methods in order to secure a confident diagnosis. Rather than being yet another encyclopedic work of reference, this volume takes a fresh approach as it resembles a series of stimulating seminars employing exemplary case material to highlight, illustrate, and succinctly discuss the key points. To this end, the reader is presented first with a section of introductory chapters and is then guided through a series of cases that pose a significant diagnostic challenge. By comprehensively comparing and contrasting two or more related entities, each such chapter illuminates an intellectual pathway through which an important diagnostic puzzle can be solved. To broaden the differential diagnosis even further, additional illustrative cases are added to each discussion. Tables also summarize key points. Written by experts in the field, Pathology of Challenging Melanocytic Neoplasms is of great value to surgical pathologists in practice and dermatologists as well as residents and fellows training in these specialties.
Medicine & Public Health. --- Pathology. --- Dermatology. --- Molecular Medicine. --- Medicine. --- Médecine --- Dermatologie --- Pathologie --- Melanoma --- Nevi and Melanomas --- Neuroendocrine Tumors --- Epithelial Cells --- Medicine --- Health Occupations --- Neoplasms by Histologic Type --- Neuroectodermal Tumors --- Cells --- Anatomy --- Neoplasms, Germ Cell and Embryonal --- Neoplasms --- Disciplines and Occupations --- Diseases --- Melanocytes --- Pathology --- Nevus --- Health & Biological Sciences --- Histopathology --- Diagnosis --- Pathogenesis. --- Malignant melanoma --- Melanocytic tumor --- Molecular biology. --- Cancer --- Neuroendocrine tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Skin --- Disease (Pathology) --- Medicine, Preventive --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology
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This book includes a collection of publications describing the molecular etiology of inherited diseases and conditions in companion animals (dogs and cats). In addition to contributing to the health of companion animals, this research also benefits humans that have similar types of diseases.
Research & information: general --- Biology, life sciences --- Canis familiaris --- dermatology --- immunology --- animal model --- skin --- TLR7 --- toll-like receptor --- syndecan binding protein --- syntenin-1 --- systemic lupus erythematosus --- SLE --- CLE --- whole-genome sequencing --- craniomandibular osteopathy --- calvarial hyperostotic syndrome --- Caffey disease --- infantile cortical hyperostosis --- rare disease --- SLC37A2 --- COL1A1 --- SLC35D1 --- Canis lupus familiaris --- whole-genome sequence --- genodermatosis --- keratinocyte --- SAM syndrome --- precision medicine --- dog --- desmosome --- acantholysis --- calcium --- veterinary medicine --- feline --- Felis catus --- brain malformation --- BMP12 --- neurodevelopment --- genetics --- genomics --- mendelian traits --- genome-wide association study --- whole genome sequencing --- mitochondrion --- phosphoenolpyruvate-carboxykinase --- inborn error of metabolism --- encephalopathy --- SSADHD --- ALDH5A1 --- GABA --- 4-hydroxybutyric acid --- succinic semialdehyde --- GWAS --- inherited --- whole genome sequence --- wgs --- laminin --- Bardet-Biedl syndrome (BBS) --- primary cilia --- ciliopathy --- BBS8 --- progressive retinal atrophy (PRA) --- retinitis pigmentosa --- canine --- dystrophinopathy --- Duchenne --- immunohistochemistry --- neurometabolic disorder --- CHILD syndrome --- ILVEN --- epidermal nevus --- diabetes mellitus --- Burmese cats --- susceptibility --- single-nucleotide polymorphism --- genetic markers --- LIPH --- obesity --- companion animals --- metabolic disease --- comparative genomics --- dogs --- cats --- horses --- contactin --- neurological disorder --- Leonberger --- Saint Bernard --- Labrador retriever --- Canis familiaris --- dermatology --- immunology --- animal model --- skin --- TLR7 --- toll-like receptor --- syndecan binding protein --- syntenin-1 --- systemic lupus erythematosus --- SLE --- CLE --- whole-genome sequencing --- craniomandibular osteopathy --- calvarial hyperostotic syndrome --- Caffey disease --- infantile cortical hyperostosis --- rare disease --- SLC37A2 --- COL1A1 --- SLC35D1 --- Canis lupus familiaris --- whole-genome sequence --- genodermatosis --- keratinocyte --- SAM syndrome --- precision medicine --- dog --- desmosome --- acantholysis --- calcium --- veterinary medicine --- feline --- Felis catus --- brain malformation --- BMP12 --- neurodevelopment --- genetics --- genomics --- mendelian traits --- genome-wide association study --- whole genome sequencing --- mitochondrion --- phosphoenolpyruvate-carboxykinase --- inborn error of metabolism --- encephalopathy --- SSADHD --- ALDH5A1 --- GABA --- 4-hydroxybutyric acid --- succinic semialdehyde --- GWAS --- inherited --- whole genome sequence --- wgs --- laminin --- Bardet-Biedl syndrome (BBS) --- primary cilia --- ciliopathy --- BBS8 --- progressive retinal atrophy (PRA) --- retinitis pigmentosa --- canine --- dystrophinopathy --- Duchenne --- immunohistochemistry --- neurometabolic disorder --- CHILD syndrome --- ILVEN --- epidermal nevus --- diabetes mellitus --- Burmese cats --- susceptibility --- single-nucleotide polymorphism --- genetic markers --- LIPH --- obesity --- companion animals --- metabolic disease --- comparative genomics --- dogs --- cats --- horses --- contactin --- neurological disorder --- Leonberger --- Saint Bernard --- Labrador retriever
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