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Nervous system --- Regeneration. --- Nerve regeneration --- Nervous system regeneration --- Neural regeneration --- Neuron regeneration --- Nerve grafting --- Regeneration (Biology) --- Degeneration and regeneration

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This book focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine, including tissue microenvironment, immunological perspectives, stem, and non-stem cell-mediated approaches, imaging techniques, biomarkers, and 3D printing technology. It also reviews the applications of biosensing technologies in regenerative medicine, including biomanufacturing, organ-on-a-chip technologies, and as indicators of therapeutic efficacy. Further, it focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.

Regenerative medicine. --- Stem cells. --- Nervous system—Regeneration. --- Biomaterials. --- Cells. --- Regenerative Medicine and Tissue Engineering. --- Stem Cell Biology. --- Regeneration and Repair in the Nervous System. --- Biomaterials-Cells. --- Organisms --- Cytology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Medicine --- Regeneration (Biology)

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This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve. With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells. This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments.

Retina --- Nervous system --- Diseases. --- Regeneration. --- Nerve regeneration --- Nervous system regeneration --- Neural regeneration --- Neuron regeneration --- Nerve grafting --- Regeneration (Biology) --- Degeneration and regeneration --- Ophthalmology. --- Neurology. --- Regenerative Medicine/Tissue Engineering. --- Medicine --- Neuropsychiatry --- Eye --- Diseases --- Neurology . --- Regenerative medicine. --- Tissue engineering. --- Biomedical engineering --- Regenerative medicine --- Tissue culture

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The complex architecture of neuronal networks together with the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successful because the mystery of nervous system development is being unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution of our knowledge of the molecular identity of the guidance cues together with their interactions and signalling pathways occurred over the past ten years. This book proposes an exhaustive and updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. An introductory chapter by C. Bouquetand F.Nothias will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.

Axons --- Nervous system --- Physiology. --- Regeneration. --- Growth. --- Developmental neurobiology --- Nerve regeneration --- Nervous system regeneration --- Neural regeneration --- Neuron regeneration --- Nerve grafting --- Regeneration (Biology) --- Nerve axons --- Neurons --- Degeneration and regeneration --- Neurosciences. --- Medicine. --- Toxicology. --- Biomedicine general. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Neural sciences --- Neurological sciences --- Neuroscience --- Toxicology --- Health Workforce --- Pharmacology. --- Biomedicine, general. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Developmental neurobiology. --- Neural stem cells. --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neurology --- Neuroscience --- Nervous system --- Neurons. --- Regeneration. --- Nerve regeneration --- Nervous system regeneration --- Neural regeneration --- Neuron regeneration --- Developmental neurology --- Neurogenesis --- Nerve cells --- Neurocytes --- Degeneration and regeneration --- Medicine. --- Neurosciences. --- Neurology. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Developmental biology --- Embryology --- Neurobiology --- Neuroplasticity --- Nerve grafting --- Regeneration (Biology) --- Cells --- Evolution --- Cytology. --- Neuropsychiatry --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Neural sciences --- Neurological sciences --- Medical sciences --- Diseases --- Neurology .