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Published monthly from January 2010, Neuro-Oncology is the official journal of the Society for Neuro-Oncology. Also affiliated with the Japan Society for Neuro-Oncology and the European Association for Neuro-Oncology it is a truly global journal in the field. Dedicated to providing superior and rapid publication of information in all areas of neuro-oncology, the journal contains peer-reviewed articles and reviews, symposia on selected topics, published abstracts of annual meetings, and society news and announcements from around the world.

Brain --- Brain Neoplasms --- Tumors --- Cancer --- Cerebrum --- Mind --- Benign Neoplasms, Brain --- Brain Neoplasm, Primary --- Brain Neoplasms, Benign --- Brain Neoplasms, Malignant --- Brain Neoplasms, Malignant, Primary --- Brain Neoplasms, Primary Malignant --- Brain Tumor, Primary --- Brain Tumor, Recurrent --- Cancer of the Brain --- Intracranial Neoplasms --- Malignant Neoplasms, Brain --- Malignant Primary Brain Neoplasms --- Neoplasms, Brain --- Neoplasms, Brain, Benign --- Neoplasms, Brain, Malignant --- Neoplasms, Brain, Primary --- Primary Brain Neoplasms --- Primary Malignant Brain Neoplasms --- Primary Malignant Brain Tumors --- Brain Cancer --- Brain Tumors --- Cancer of Brain --- Malignant Primary Brain Tumors --- Neoplasms, Intracranial --- Benign Brain Neoplasm --- Benign Brain Neoplasms --- Benign Neoplasm, Brain --- Brain Benign Neoplasm --- Brain Benign Neoplasms --- Brain Cancers --- Brain Malignant Neoplasm --- Brain Malignant Neoplasms --- Brain Neoplasm --- Brain Neoplasm, Benign --- Brain Neoplasm, Malignant --- Brain Neoplasms, Primary --- Brain Tumor --- Brain Tumors, Primary --- Brain Tumors, Recurrent --- Cancer, Brain --- Cancers, Brain --- Intracranial Neoplasm --- Malignant Brain Neoplasm --- Malignant Brain Neoplasms --- Malignant Neoplasm, Brain --- Neoplasm, Brain --- Neoplasm, Intracranial --- Primary Brain Neoplasm --- Primary Brain Tumor --- Primary Brain Tumors --- Recurrent Brain Tumor --- Recurrent Brain Tumors --- Tumor, Brain --- Tumors, Brain --- Cancer. --- Tumors. --- Central nervous system --- Head --- Health Sciences --- Clinical Medicine --- Neurology --- Oncology --- Brain Metastases --- Brain Metastase --- Brain Neoplasms. --- Health and Wellbeing. --- Cerveau --- Tumeurs

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'Neuro-Oncology Practice' focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines who have focused their careers on clinical patient care, and who want to apply the latest treatment advances to their practice.

Brain --- Cancer --- Brain Neoplasms. --- Tumors --- Patients --- Tumors. --- Patients. --- Cancer survivors --- Survivors, Cancer --- Benign Neoplasms, Brain --- Brain Neoplasm, Primary --- Brain Neoplasms, Benign --- Brain Neoplasms, Malignant --- Brain Neoplasms, Malignant, Primary --- Brain Neoplasms, Primary Malignant --- Brain Tumor, Primary --- Brain Tumor, Recurrent --- Cancer of the Brain --- Intracranial Neoplasms --- Malignant Neoplasms, Brain --- Malignant Primary Brain Neoplasms --- Neoplasms, Brain --- Neoplasms, Brain, Benign --- Neoplasms, Brain, Malignant --- Neoplasms, Brain, Primary --- Primary Brain Neoplasms --- Primary Malignant Brain Neoplasms --- Primary Malignant Brain Tumors --- Brain Cancer --- Brain Tumors --- Cancer of Brain --- Malignant Primary Brain Tumors --- Neoplasms, Intracranial --- Benign Brain Neoplasm --- Benign Brain Neoplasms --- Benign Neoplasm, Brain --- Brain Benign Neoplasm --- Brain Benign Neoplasms --- Brain Cancers --- Brain Malignant Neoplasm --- Brain Malignant Neoplasms --- Brain Neoplasm --- Brain Neoplasm, Benign --- Brain Neoplasm, Malignant --- Brain Neoplasms, Primary --- Brain Tumor --- Brain Tumors, Primary --- Brain Tumors, Recurrent --- Cancer, Brain --- Cancers, Brain --- Intracranial Neoplasm --- Malignant Brain Neoplasm --- Malignant Brain Neoplasms --- Malignant Neoplasm, Brain --- Neoplasm, Brain --- Neoplasm, Intracranial --- Primary Brain Neoplasm --- Primary Brain Tumor --- Primary Brain Tumors --- Recurrent Brain Tumor --- Recurrent Brain Tumors --- Tumor, Brain --- Tumors, Brain --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Cerebrum --- Mind --- Central nervous system --- Head --- Brain Metastases --- Brain Metastase --- Nervous system --- Health and Wellbeing.

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With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. This volume fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types - lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection. *The only comprehensive reference detailing the link between primary cancers and brain metastases *Aids the target audience in determining the incidence of brain metastases in patients with a primary cancer *Provided education about the potential use of biomarkers for early detection, diagnosis and prevention of the spread of primary cancer to the brain *Documents temporal and gender-related trends in brain metastases from other cancers *Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available.

Brain --- Metastasis. --- Brain Neoplasms --- Cancer. --- Cancer --- Therapy. --- Benign Neoplasms, Brain --- Brain Neoplasm, Primary --- Brain Neoplasms, Benign --- Brain Neoplasms, Malignant --- Brain Neoplasms, Malignant, Primary --- Brain Neoplasms, Primary Malignant --- Brain Tumor, Primary --- Brain Tumor, Recurrent --- Cancer of the Brain --- Intracranial Neoplasms --- Malignant Neoplasms, Brain --- Malignant Primary Brain Neoplasms --- Neoplasms, Brain --- Neoplasms, Brain, Benign --- Neoplasms, Brain, Malignant --- Neoplasms, Brain, Primary --- Primary Brain Neoplasms --- Primary Malignant Brain Neoplasms --- Primary Malignant Brain Tumors --- Brain Cancer --- Brain Metastases --- Brain Tumors --- Cancer of Brain --- Malignant Primary Brain Tumors --- Neoplasms, Intracranial --- Benign Brain Neoplasm --- Benign Brain Neoplasms --- Benign Neoplasm, Brain --- Brain Benign Neoplasm --- Brain Benign Neoplasms --- Brain Cancers --- Brain Malignant Neoplasm --- Brain Malignant Neoplasms --- Brain Metastase --- Brain Neoplasm --- Brain Neoplasm, Benign --- Brain Neoplasm, Malignant --- Brain Neoplasms, Primary --- Brain Tumor --- Brain Tumors, Recurrent --- Cancer, Brain --- Intracranial Neoplasm --- Malignant Brain Neoplasm --- Malignant Brain Neoplasms --- Malignant Neoplasm, Brain --- Neoplasm, Brain --- Neoplasm, Intracranial --- Primary Brain Neoplasm --- Primary Brain Tumor --- Primary Brain Tumors --- Recurrent Brain Tumor --- Recurrent Brain Tumors --- Tumor, Brain --- Cerebrum --- Mind --- Central nervous system --- Head --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Dissemination --- Metastasis --- Brain Neoplasms.

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Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.

Neuroimmunology. --- Spinal cord --- Wounds and injuries. --- Neuroimmunomodulation --- Immunology --- Neurosciences --- Spinal Cord Neoplasms. --- Brain Neoplasms. --- Nervous System Diseases --- immunology. --- Benign Neoplasms, Brain --- Brain Neoplasm, Primary --- Brain Neoplasms, Benign --- Brain Neoplasms, Malignant --- Brain Neoplasms, Malignant, Primary --- Brain Neoplasms, Primary Malignant --- Brain Tumor, Primary --- Brain Tumor, Recurrent --- Cancer of the Brain --- Intracranial Neoplasms --- Malignant Neoplasms, Brain --- Malignant Primary Brain Neoplasms --- Neoplasms, Brain --- Neoplasms, Brain, Benign --- Neoplasms, Brain, Malignant --- Neoplasms, Brain, Primary --- Primary Brain Neoplasms --- Primary Malignant Brain Neoplasms --- Primary Malignant Brain Tumors --- Brain Cancer --- Brain Metastases --- Brain Tumors --- Cancer of Brain --- Malignant Primary Brain Tumors --- Neoplasms, Intracranial --- Benign Brain Neoplasm --- Benign Brain Neoplasms --- Benign Neoplasm, Brain --- Brain Benign Neoplasm --- Brain Benign Neoplasms --- Brain Cancers --- Brain Malignant Neoplasm --- Brain Malignant Neoplasms --- Brain Metastase --- Brain Neoplasm --- Brain Neoplasm, Benign --- Brain Neoplasm, Malignant --- Brain Neoplasms, Primary --- Brain Tumor --- Brain Tumors, Recurrent --- Cancer, Brain --- Intracranial Neoplasm --- Malignant Brain Neoplasm --- Malignant Brain Neoplasms --- Malignant Neoplasm, Brain --- Neoplasm, Brain --- Neoplasm, Intracranial --- Primary Brain Neoplasm --- Primary Brain Tumor --- Primary Brain Tumors --- Recurrent Brain Tumor --- Recurrent Brain Tumors --- Tumor, Brain --- Intramedullary Spinal Cord Neoplasms, Primary --- Neoplasms, Spinal Cord --- Primary Intramedullary Spinal Cord Neoplasms --- Primary Spinal Cord Neoplasms, Intramedullary --- Spinal Cord Neoplasms, Benign --- Spinal Cord Neoplasms, Intradural-Extramedullary --- Spinal Cord Neoplasms, Intramedullary --- Spinal Cord Neoplasms, Malignant --- Spinal Cord Neoplasms, Primary Intramedullary --- Tumors, Spinal Cord --- Intradural-Extramedullary Spinal Cord Neoplasms --- Intramedullary Spinal Cord Neoplasms --- Intradural Extramedullary Spinal Cord Neoplasms --- Neoplasm, Spinal Cord --- Spinal Cord Neoplasm --- Spinal Cord Neoplasms, Intradural Extramedullary --- Spinal Cord Tumor --- Spinal Cord Tumors --- Tumor, Spinal Cord --- Medicine—Research. --- Biology—Research. --- Medical genetics. --- Biomedical Research. --- Medical Genetics. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects

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This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.

Spinal Cord Neoplasms. --- Brain Neoplasms --- Benign Neoplasms, Brain --- Brain Neoplasm, Primary --- Brain Neoplasms, Benign --- Brain Neoplasms, Malignant --- Brain Neoplasms, Malignant, Primary --- Brain Neoplasms, Primary Malignant --- Brain Tumor, Primary --- Brain Tumor, Recurrent --- Cancer of the Brain --- Intracranial Neoplasms --- Malignant Neoplasms, Brain --- Malignant Primary Brain Neoplasms --- Neoplasms, Brain --- Neoplasms, Brain, Benign --- Neoplasms, Brain, Malignant --- Neoplasms, Brain, Primary --- Primary Brain Neoplasms --- Primary Malignant Brain Neoplasms --- Primary Malignant Brain Tumors --- Brain Cancer --- Brain Metastases --- Brain Tumors --- Cancer of Brain --- Malignant Primary Brain Tumors --- Neoplasms, Intracranial --- Benign Brain Neoplasm --- Benign Brain Neoplasms --- Benign Neoplasm, Brain --- Brain Benign Neoplasm --- Brain Benign Neoplasms --- Brain Cancers --- Brain Malignant Neoplasm --- Brain Malignant Neoplasms --- Brain Metastase --- Brain Neoplasm --- Brain Neoplasm, Benign --- Brain Neoplasm, Malignant --- Brain Neoplasms, Primary --- Brain Tumor --- Brain Tumors, Recurrent --- Cancer, Brain --- Intracranial Neoplasm --- Malignant Brain Neoplasm --- Malignant Brain Neoplasms --- Malignant Neoplasm, Brain --- Neoplasm, Brain --- Neoplasm, Intracranial --- Primary Brain Neoplasm --- Primary Brain Tumor --- Primary Brain Tumors --- Recurrent Brain Tumor --- Recurrent Brain Tumors --- Tumor, Brain --- Intramedullary Spinal Cord Neoplasms, Primary --- Neoplasms, Spinal Cord --- Primary Intramedullary Spinal Cord Neoplasms --- Primary Spinal Cord Neoplasms, Intramedullary --- Spinal Cord Neoplasms, Benign --- Spinal Cord Neoplasms, Intradural-Extramedullary --- Spinal Cord Neoplasms, Intramedullary --- Spinal Cord Neoplasms, Malignant --- Spinal Cord Neoplasms, Primary Intramedullary --- Tumors, Spinal Cord --- Intradural-Extramedullary Spinal Cord Neoplasms --- Intramedullary Spinal Cord Neoplasms --- Intradural Extramedullary Spinal Cord Neoplasms --- Neoplasm, Spinal Cord --- Spinal Cord Neoplasm --- Spinal Cord Neoplasms, Intradural Extramedullary --- Spinal Cord Tumor --- Spinal Cord Tumors --- Tumor, Spinal Cord --- Medicine—Research. --- Biology—Research. --- Neurology. --- Internal medicine. --- Immunology. --- Biomedical Research. --- Internal Medicine. --- Immunobiology --- Life sciences --- Serology --- Medicine, Internal --- Medicine --- Nervous system --- Neuropsychiatry --- Diseases --- Brain Neoplasms.