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Présentation de l'éditeur : "Les essais cliniques et l'évaluation des médicaments chez les personnes âgées. Les patients âgés sont encore trop souvent exclus des essais thérapeutiques contrôlés randomisés alors que la population âgée, aux particularités nombreuses, connaît une croissance démographique rapide et qu'elle est la plus forte consommatrice de médicaments. Ce paradoxe limite la pertinence des résultats des essais cliniques et ne tient pas compte de la susceptibilité des patients âgés aux effets indésirables. Cette prise de conscience amorcée dans le passé devrait se traduire par une réorientation de la recherche vers cette population et une application des recommandations internationales, relancées par la Commission Européenne et l'Agence Européenne des Médicaments et récemment confirmées par le Rapport « Politique du médicament en EHPAD, 2013 ». Tout le mérite de l'auteur est d'avoir instruit son dossier sur les différences à considérer chez le sujet âgé (en pharmacocinétique, en pharmacodynamie ou en profil de tolérance) pour définir les particularités méthodologiques des essais thérapeutiques à mener, particularités qui ouvrent la voie à une nouvelle réglementation tout à fait propice à des initiatives et à de nouvelles discussions permettant de rapprocher prescription de médicaments et situation clinique réelle."

Drugs, Investigational --- Aged --- Geriatric Assessment --- Drug Evaluation --- Essais cliniques des médicaments --- Évaluation gériatrique --- Pharmacologie gériatrique --- Clinical Trials as Topic. --- Geriatric Assessment. --- Essais cliniques des médicaments. --- Évaluation gériatrique. --- Pharmacologie gériatrique. --- Clinical Trials as Topic

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Personnes âgées --- Consultation médicale. --- Personnes âgées --- Évaluation gériatrique. --- Alzheimer, Maladie d'. --- Geriatric assessment --- Aged --- Geriatrics --- Alzheimer Disease --- Maladies. --- Soins médicaux. --- diagnosis --- diagnosis --- Geriatric assessment --- Aged --- Geriatrics --- Alzheimer Disease --- diagnosis --- diagnosis

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Geriatric Assessment --- Aged --- Frail Elderly --- psychology --- Vulnérabilité (psychologie) --- Évaluation gériatrique --- Personnes âgées --- Santé et hygiène --- Psychologie --- Évaluation gériatrique. --- Santé et hygiène. --- Psychologie. --- Aged - psychology --- Vulnérabilité (psychologie) --- Évaluation gériatrique. --- Personnes âgées --- Santé et hygiène. --- Gérontopsychologie. --- Vulnerability (Personality trait) --- Older people --- Geriatric Assessment. --- Psychology. --- Mental health. --- Gérontopsychologie.

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The average age of the world’s population is increasing at an unprecedented rate and this increase is changing the world. This “Silver tsunami” emphasizes the need to provide advanced training in epidemiology and increase the cadre of experts in the study of aging. This book is designed to summarize unique methodological issues relevant to the study of the epidemiology of aging, biomarkers of aging and the biology/physiology of aging and in-depth discussions of the etiology and epidemiology of common geriatric syndromes and diseases. Contributing authors in the book represent many disciplines, not only epidemiology and clinical geriatrics, but also demography, health services, research, cardiovascular disease, diabetes, psychiatry, neurology, social services, musculoskeletal diseases and cancer. The aim of the book is to provide a broad multidisciplinary background for any student/researcher interested in aging. The material in the book is organized and comprehensive. It represents the most up-to-date information on the scientific issues in aging research written by academics who specialize in research and training in the broad field of aging. The structure and organization of the book reflects our course series in the Epidemiology of Aging starting with the broad issues of demography and methodology, and then addressing specific health conditions and geriatric conditions common to older persons.

Aging. --- Mortality -- Aged. --- Older people -- Diseases -- Epidemiology. --- Older people. --- Aging --- Epidemiology --- Investigative Techniques --- Quality of Health Care --- Growth and Development --- Data Collection --- Adult --- Health Care Quality, Access, and Evaluation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Age Groups --- Physiological Processes --- Health Care --- Persons --- Physiological Phenomena --- Phenomena and Processes --- Named Groups --- Aged --- Epidemiologic Methods --- Methods --- Geriatric Assessment --- Epidemiologic Factors --- Research --- Older people --- Epidemiology. --- Geriatrics. --- Gerontology. --- Diseases. --- Age --- Ageing --- Senescence --- Old age --- Physiological effect --- Diseases --- Medicine. --- Biomedicine. --- Biomedicine general. --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Public health --- Social sciences --- Geriatrics --- Medicine --- Health and hygiene --- Research. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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In recent decades, life expectancy has been increasing. This is a historical milestone in the history of humanity. We have never lived so long before. In these circumstances, giving the best care to older adults efficiently is one of the greatest challenges of developed countries. This book explores different initiatives that result in the improvement of health conditions of older adults, such as multicomponent physical exercise programs, interventions that try to avoid loneliness and social isolation, and multidisciplinary assessment, and the treatment of frailty and other geriatric syndromes, of the elderly in various settings such as the Emergency Unit, Orthogeriatrics, and Oncogeriatrics. This book offers different manuscripts to readers, each trying to improve life satisfaction, quality of life, and life expectancy in older adults in different scenarios. It is up to us to achieve these goals. We are sure that these interesting chapters will contribute to improving clinical practices. Following the completion of the Special Issue "Health Care for Older Adults" for the international Journal of Environmental Research and Public Health, the Guest Editors felt the satisfaction of having reached 18 published manuscripts and the possibility of transforming this volume into a book. This book was born from the need to show how health and social advances have increased human longevity as never before. We live longer, knowing more and more the epigenetic mechanisms of this longevity, as extended aging also coexists with the least favorable aging trajectories. Among them, a syndrome stands out from the gerontological and geriatric perspective: frailty. Due to the pandemic, a social problem has increased its presence in clinical practice: ageism. Older adults have found it difficult to access the necessary clinical resources due to the simple matter of age. However, at this moment, we are able to detect and to reverse frailty. In the same way, we should aim to prevent loneliness and social isolation, involved in social frailty. Geriatric syndromes are underdiagnosed and undertreated, but clinical and geriatric knowledge provide diagnostic tools and non-pharmacological approaches to prevent and to treat them. All health professionals working together in an interdisciplinary team could improve the clinical practices to develop a quality health care for older adults, improving their life satisfaction and quality of life perception too.

Public health & preventive medicine --- neck stabilization exercise --- nonspecific neck pain --- salt pack --- thermotherapy --- anticholinergic drugs --- pneumonia --- elderly --- potentially inappropriate medication --- pharmacoepidemiology --- infrared thermography --- cutaneous temperature --- skin blood flow --- dementia --- body temperature --- thermal sensation --- thermal comfort --- imaging --- mapping --- environmental temperature --- frailty --- COVID-19 --- aging --- physical activity --- mental health --- social relationships --- social frailty --- older adults --- life satisfaction --- accidental falls --- research hotspot --- CiteSpace --- knowledge domain visualization --- geriatric syndromes --- healthy aging --- exercise --- histones --- DNA methylation --- non-coding RNA --- hip fractures --- geriatric assessment --- orthogeriatric care --- functional recovery --- mortality --- hip fracture surgery --- multidisciplinary care --- predictive model --- hip fracture --- gait recovery --- feasibility --- frailty index --- psychometrics --- reliability --- validity --- ageing --- qualitative research --- primary health care --- loneliness --- social capital --- colorectal cancer --- comprehensive geriatric assessment --- geriatric liaison --- multicomponent programs --- functional capacity --- occupational therapy --- occupational function --- social network --- social isolation --- posterior occlusal support --- maximum occlusal force --- masticatory function --- standing motion --- removable prostheses --- Eichner index --- fracture fixation --- geriatric --- intertrochanteric fractures --- prognostic factors --- Thai --- aged people --- STOPP/START --- Beers criteria --- medical prescriptions for chronic pathologies --- inappropriate prescribing --- nursing --- delirium --- machine learning technique --- random forest --- neck stabilization exercise --- nonspecific neck pain --- salt pack --- thermotherapy --- anticholinergic drugs --- pneumonia --- elderly --- potentially inappropriate medication --- pharmacoepidemiology --- infrared thermography --- cutaneous temperature --- skin blood flow --- dementia --- body temperature --- thermal sensation --- thermal comfort --- imaging --- mapping --- environmental temperature --- frailty --- COVID-19 --- aging --- physical activity --- mental health --- social relationships --- social frailty --- older adults --- life satisfaction --- accidental falls --- research hotspot --- CiteSpace --- knowledge domain visualization --- geriatric syndromes --- healthy aging --- exercise --- histones --- DNA methylation --- non-coding RNA --- hip fractures --- geriatric assessment --- orthogeriatric care --- functional recovery --- mortality --- hip fracture surgery --- multidisciplinary care --- predictive model --- hip fracture --- gait recovery --- feasibility --- frailty index --- psychometrics --- reliability --- validity --- ageing --- qualitative research --- primary health care --- loneliness --- social capital --- colorectal cancer --- comprehensive geriatric assessment --- geriatric liaison --- multicomponent programs --- functional capacity --- occupational therapy --- occupational function --- social network --- social isolation --- posterior occlusal support --- maximum occlusal force --- masticatory function --- standing motion --- removable prostheses --- Eichner index --- fracture fixation --- geriatric --- intertrochanteric fractures --- prognostic factors --- Thai --- aged people --- STOPP/START --- Beers criteria --- medical prescriptions for chronic pathologies --- inappropriate prescribing --- nursing --- delirium --- machine learning technique --- random forest