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Ergot alkaloids produced by fungi have a basic chemical structure but different chemical moieties at substituent sites resulting in various forms of alkaloids that are distinguishable from one another. Since the ergoline ring structure found in ergot alkaloids is similar to that of biogenic amines (neurotransmitters), a variety of physiological effects can result after ingestion. Research involving ergot alkaloids is an increasing important global issue as more governments pass laws that limit permissible levels of ergot alkaloids in both foodstuffs and feedstuffs. Regardless of whether these compounds are found directly in foodstuffs or in feed/plants given to forage animals (i.e., cattle, sheep, horses, and goats), introduction of these compounds can complicate the food supply. In addition, toxicosis resulting from alkaloids can be a costly hindrance, with mounting annual production losses associated with forage-animal production systems that impact other agricultural and food based industries. Recent advances for the analysis of these compounds in different matrices as well as the understanding the role these compounds play in biological pathways have begun to help address the issue. The proposed Research Topic “Recent Investigations of Ergot Alkaloids Incorporated into Plant and/or Animal Systems“ will develop a forum where different groups can share recent data where their investigations could include (but are not limited to) how ergot alkaloids: i) influence specific biologic pathways in plant and/or animal systems when introduced, ii) were analyzed in either in biological matrices (e.g. food / feed, blood, urine, etc.), and/or iii) are distributed throughout materials, specifically in plant and/or animal tissues. Each publication must include a description of the methodologies used with the results gained. Inter- and multi-disciplinary approach to this field is desired and would be beneficial in this Research Topic.
Ergot alkaloids. --- Food supply --- Adrenergic alpha blockers --- Alkaloids --- Ergot --- Food control --- Produce trade --- Agriculture --- Food security --- Single cell proteins --- Toxicosis --- fungus --- Animal science --- Ergot Alkaloids --- Ergotism --- plant science
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This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientists at the forefront of this rapidly growing field. Reflecting the particular significance in recent years of efficient and selective procedures employing enzymes for preparative purposes in the carbohydrate field, a major proportion of the articles focus on these biocatalytic methods. In addition, recent strategies for the construction of unusual carbohydrates structures employing novel and creative methodologies are highlighted. Further, particular emphasis is placed on very complex saccharide structures as well as on special solutions to problems that are particularly challenging.
Carbohydrates --- Oligosaccharides --- Glycoconjugates --- Glycoconjugués --- Synthesis. --- Synthèse. --- Chemistry. --- Organic chemistry. --- Biochemistry. --- Organic Chemistry. --- Biochemistry, general. --- Glycoconjugués --- Synthèse. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Organic chemistry --- Composition --- Carbohydrates - Synthesis. --- Oligosaccharides - Synthesis. --- Glycoconjugates - Synthesis. --- OLIGOSACCHARIDES --- OLIGOSACCHARIDES, CONJUGATES --- GLYCOSIDE HYDROLASES --- LIPASES --- SIALIC ACIDS --- GLYCOSYLATION --- GLYCOPEPTIDES --- ERGOT ALKALOIDS --- PREPARATION
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Crop contamination by mycotoxins is a global problem that poses significant economic burdens due to a number of factors, including the food/feed losses that are caused by reduced production rates; the resulting adverse effects on human and animal health and productivity; and the trade losses associated with the costs incurred by inspection, sampling, and analysis before and after shipments. In this scenario, the development of fit-for-purpose analytical methods for regulated and (re)-emerging mycotoxins continues to be a dynamic research area. Some of the current trends in this research area are presented in this book. The collected contributions address either the need for improved methods for mycotoxin detection addressed by new or incoming regulation (ergot alkaloids and Alternaria toxins) as well as methods for the detection of multiple mycotoxins. New approaches to enhance the performance of well-established methodologies, such as the enzyme-linked immunosorbent assay (ELISA) and fluorescence polarization immunoassays (FPIA), are also addressed.
Research & information: general --- Chemistry --- Analytical chemistry --- FPIA --- mycotoxin --- OTA --- detection methods --- food safety --- monoclonal antibody (mAb) --- tracer --- HPLC --- trichothecenes --- zearalenone --- Fusarium toxins --- wheat --- liquid chromatography-mass spectrometry --- official control --- collaborative study --- ergot alkaloids --- sum parameter method --- hydrazinolysis --- esterification --- swine feed --- dairy feed --- UHPLC-MS/MS --- aflatoxin B1 --- recombinant AflR gene --- VICAM --- I-ELISA --- peanut --- wheat flour --- milk powder --- LC-MS/MS method --- cereal products --- occurrence --- alternariol --- antibody --- ELISA --- hapten design --- immunoassay --- linker site --- FPIA --- mycotoxin --- OTA --- detection methods --- food safety --- monoclonal antibody (mAb) --- tracer --- HPLC --- trichothecenes --- zearalenone --- Fusarium toxins --- wheat --- liquid chromatography-mass spectrometry --- official control --- collaborative study --- ergot alkaloids --- sum parameter method --- hydrazinolysis --- esterification --- swine feed --- dairy feed --- UHPLC-MS/MS --- aflatoxin B1 --- recombinant AflR gene --- VICAM --- I-ELISA --- peanut --- wheat flour --- milk powder --- LC-MS/MS method --- cereal products --- occurrence --- alternariol --- antibody --- ELISA --- hapten design --- immunoassay --- linker site
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"The Global Impact of Ergot Alkaloids" addresses the very broad topic of ergot alkaloids and the influence that they have on many facets of life. The content in this Special Issue pertains to research studying fungi, plants, livestock, and humans. While the perspectives of each paper may differ, the common aspect is the interest and emphasis on ergot alkaloids. These compounds cross the spectrum from feared toxins to potential pharmaceutical discoveries. The research included spans the globe and has content that will attract the interest of readers from many different backgrounds.
Medicine --- Medical toxicology --- ergot alkaloids --- strain improvement --- UV --- EMS --- Penicillium citrinum --- response surface methodology --- PBD --- BBD --- integrative interactomics --- integrome --- metabolomics --- microbiome --- tall fescue --- Epichloë coenophiala --- fescue toxicosis --- ergot alkaloid occurrence --- sclerotia --- cereals --- LC-MS/MS --- correlation --- survey --- beef cattle --- endophyte --- ergot alkaloid --- isoflavone --- metabolites --- genetic tolerance --- cytokines --- cow productivity --- CRISPR/Cas9 --- non-transgenic engineered fungi --- genome editing --- genome sequencing --- MinION --- nanopore --- secondary metabolites --- endophyte transmission --- livestock safety --- insect testing --- quality control --- alkaloid profile --- single nucleotide polymorphism --- milk production --- calf growth --- acute ergot exposure --- ergot toxicity --- sheep --- vasoconstriction --- adrenergic receptors --- ergot --- ethnopharmacology --- abortion --- childbirth --- ergovaline --- horse pastures --- pregnant mares --- species composition --- ergot fungi --- gene divergence --- gene diversity --- indole diterpenes --- phylogeny --- Claviceps purpurea --- fungal plant pathogen --- biosynthetic gene cluster --- mycotoxins --- untargeted metabolomics --- mass spectrometry --- blood vessel --- myograph --- serotonin --- ergot alkaloids --- strain improvement --- UV --- EMS --- Penicillium citrinum --- response surface methodology --- PBD --- BBD --- integrative interactomics --- integrome --- metabolomics --- microbiome --- tall fescue --- Epichloë coenophiala --- fescue toxicosis --- ergot alkaloid occurrence --- sclerotia --- cereals --- LC-MS/MS --- correlation --- survey --- beef cattle --- endophyte --- ergot alkaloid --- isoflavone --- metabolites --- genetic tolerance --- cytokines --- cow productivity --- CRISPR/Cas9 --- non-transgenic engineered fungi --- genome editing --- genome sequencing --- MinION --- nanopore --- secondary metabolites --- endophyte transmission --- livestock safety --- insect testing --- quality control --- alkaloid profile --- single nucleotide polymorphism --- milk production --- calf growth --- acute ergot exposure --- ergot toxicity --- sheep --- vasoconstriction --- adrenergic receptors --- ergot --- ethnopharmacology --- abortion --- childbirth --- ergovaline --- horse pastures --- pregnant mares --- species composition --- ergot fungi --- gene divergence --- gene diversity --- indole diterpenes --- phylogeny --- Claviceps purpurea --- fungal plant pathogen --- biosynthetic gene cluster --- mycotoxins --- untargeted metabolomics --- mass spectrometry --- blood vessel --- myograph --- serotonin
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#KVHA:American Studies --- #KVHA:Drugsverslaving; Verenigde Staten --- Drug abuse --- LSD (Drug) --- Social history --- Acid (Drug) --- Lysergic acid diethylamide --- Lysergide --- Diethylamine --- Ergot alkaloids --- Hallucinogenic drugs --- Serotonin --- Antagonists --- United States. --- Agjencia Qendrore e Inteligjencës --- Central Intelligence Agency (U.S.) --- CIA (Central Intelligence Agency (U.S.)) --- CIP (United States. Centrālās izlūkošanas pārvalde) --- Mei-kuo chung yang chʻing pao chü --- National Security Council (U.S.). --- Si Aing Ei --- T︠S︡entralʹnoe razvedyvatelʹnoe upravlenie SShA --- T︠S︡RU SShA --- T︠S︡RU (T︠S︡entralʹnoe razvedyvatelʹnoe upravlenie SShA) --- ЦРУ США --- ЦРУ (Центральное разведывательное управление США) --- Центральное разведывательное управление США --- ארצות הברית. --- 美國. --- National Security Council (U.S.) --- CIA (Central Intelligence Agency) --- CENTRAL INTELLIGENCE AGENCY (CIA) --- LSD (DROGUE) --- POLYTOXICOMANIE --- HISTOIRE SOCIALE --- ETATS-UNIS --- 1960-1970 --- 1970 --- -Drug abuse --- -CENTRAL INTELLIGENCE AGENCY (CIA) --- 1970-
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Il fuoco di Sant’Antonio è una malattia, certo! Ma quale? Per noi Italiani è sicuramente l’Herpes zoster; ma è sempre stato così? Ebbene, no! Sant’Antonio Abate aveva la fama di taumaturgo e guaritore già in vita; così, quando le sue spoglie arrivarono in Europa dopo l’anno Mille, tutti coloro che soffrivano di malattie dolorose e urenti lo imploravano affinché li guarisse da quel “fuoco” che li tormentava. Ma quali erano queste malattie così dolorose? Le antiche cronache sono spesso troppo succinte o romanzate per orientarci nella diagnosi ma erisipela, sifilide, ergotismo hanno fatto certamente buona compagnia allo zoster. L’ergotismo soprattutto era terrorizzante perché compariva a ondate imprevedibili e, come la peste, colpiva i virtuosi come i viziosi, scardinando l’interpretazione del dolore come conseguenza del peccato. Come se non bastasse, l’ergotismo non solo provocava terribili sofferenze ma spesso anche stati di confusione mentale e di delirio sicuramente attribuibili al demonio. Bisogna aspettare l’età dei Lumi per mandare in soffitta le superstizioni che infestavano la medicina e allora l’ergotismo si rivela essere non più una maledizione ma solo una malattia, un effetto del consumo di pane nero alloiato. Lo studio degli allucinogeni e la scoperta dell’LSD mettono la parola fine all’interpretazione mistico-religiosa di alcune patologie e gettano inaspettatamente nuova luce su quello che fu il segreto meglio custodito dell’Antichità: il culto dei Misteri Eleusini. In questo libro, la storia del fuoco di Sant’Antonio si dipana dai racconti medioevali sino all’odierna virologia e suggerisce che la curiosità e la scienza sono l’unico antidoto contro la superstizione e il mistero.
Anthony, -- of Egypt, Saint, -- ca. 250-355 or 6. --- Christian saints -- Egypt -- Biography. --- Electronic books. -- local. --- Ergotism. --- LSD (Drug). --- Shingles (Disease). --- Herpesviridae Infections --- Plant Poisoning --- History --- Mycotoxicosis --- Poisoning --- Humanities --- DNA Virus Infections --- Substance-Related Disorders --- Diseases --- Virus Diseases --- Herpes Zoster --- Ergotism --- History of Medicine --- Medicine --- Health & Biological Sciences --- Dermatology --- Christian saints --- Shingles (Disease) --- LSD (Drug) --- Anthony, --- Ergot --- Saint Anthony's fire --- Acid (Drug) --- Lysergic acid diethylamide --- Lysergide --- Acute posterior ganglionitis --- Ganglionitis, Acute posterior --- Herpes zoster --- Posterior ganglionitis, Acute --- Zona (Disease) --- Zoster (Disease) --- Toxicology --- Anbā Anṭūnīyūs, --- Anthony the Abbot, --- Antoine, --- Antoniĭ Velikiĭ, --- Antonio, --- Antonius, --- Antonius Magnus, --- Antony, --- Qiddīs Anṭūnīyūs, --- قديس مصر أنطونيوس --- Medicine. --- Religion. --- History. --- Science. --- Dermatology. --- Anthropology. --- Medicine & Public Health. --- History of Science. --- Science, general. --- Religious Studies, general. --- Mycotoxicoses --- Diethylamine --- Ergot alkaloids --- Hallucinogenic drugs --- Serotonin --- Herpesvirus diseases --- Antagonists --- Science, Humanities and Social Sciences, multidisciplinary. --- Religion, Primitive --- Atheism --- God --- Irreligion --- Religions --- Theology --- Human beings --- Annals --- Auxiliary sciences of history --- Skin --- Primitive societies --- Social sciences
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Natural products are increasingly attracting attention from both basic and applied science. Plant secondary metabolites, especially alkaloids, are receiving interest from a wide range of researchers due to their biological activity. They are produced to protect plants from diseases and herbivores. Therefore, they reveal a toxic activity that affects organisms at various levels of biological organization. A growing amount of research is proving their antimicrobial, antifungal, insecticidal, and anticancer activities. That makes them applicable in various fields from medicine, to pharmacology, veterinary, and toxicology, to crop protection. This Special Issue of Toxins, “Biological Activities of Alkaloids: From Toxicology to Pharmacology"", collects 15 manuscripts describing the ecological, biological, pharmacological, and toxicological effects as well as structural and analytical aspects of plant alkaloids, their mode of action, and possible application in veterinary, medicine, and plant protection. These studies prove the potential for alkaloid application in various areas of science.
leukemia --- n/a --- biodistribution --- glycoalkaloids --- insect heart --- Solanum melongena L. --- antibacterial --- alkaloid --- ?-carboline --- Ovarian cancer --- Chelidonium majus --- secondary metabolites --- lindoldhamine --- livestock --- insect --- chanoclavine --- bisbenzylisoquinoline alkaloid --- cytotoxic activity --- Staphylococcus aureus --- antioxidant --- acid-sensing ion channel subtype 1a --- malonylated form --- HPLC-DAD --- ergot alkaloids --- nociception --- macrophage --- Arecoline --- Macleaya cordata --- antifungal --- neuropathic pain --- Corydalis lutea --- antiviral --- Curine --- lung cancer cells --- lipopolysaccharide --- Epichloë --- Meconopsis cambrica --- Berberis thunbergii --- SRC --- Dicentra spectabilis --- apoptosis --- endophyte --- natural sources --- dehydrocrenatidine --- neutrophil --- EGFR --- anticancer --- solamargine --- berberine --- isoquinoline alkaloids --- natural products --- Radix Aconiti Lateralis preparations --- short-term and long-term usage --- inflammation --- acute toxicity --- Mahonia aquifolia --- Palmatine --- sanguinarine --- Rutidea parviflora --- voltage-gated sodium channels --- cytotoxicity --- toxicology --- malonyl-solamargine --- alkaloids --- acetylcholinesterase --- beetles --- Fumaria officinalis --- antimicrobial activity --- solasonine --- FAK --- plant secondary metabolites --- di-ester diterpenoid alkaloids --- mAchR3 --- subchronic feeding study --- mono-ester diterpenoid alkaloids --- Tenebrio molitor --- Apoptosis --- reproduction
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The book deals with mycotoxins, their presence in various types of food, and how to prevent their presence in food . In addition to well-known molecules, such as aflatoxins or fumonisins, some contributors have dealt with emerging mycotoxins (e.g., alternaria toxins, botryodiplodin). Readers of the book can also find a new approach to reducing aflatoxins and fumonisins in food. In conclusion, the book presents both new mycotoxins and new information on old mycotoxins.
Humanities --- Social interaction --- Atlantic salmon --- zebrafish --- liquid chromatography high-resolution mass spectrometry --- mycotoxins --- phytoestrogens --- plant-based feed --- rice --- sterigmatocystin --- STC --- deoxynivalenol --- DON --- growing season --- azoxystrobin --- fungicide --- Fumonisins --- Fusarium spp. --- food contamination --- health issues --- secondary metabolites --- Aflatoxins --- binding --- food safety --- biocontrol --- food discipline --- ergot alkaloids --- ergochromes --- secalonic acid --- cereals --- tetrahydroxanthones --- Claviceps --- aflatoxin --- mycotoxin --- black soldier fly --- BSFL --- Hermetia illucens --- S9 fraction --- cytochrome P450 --- metabolic conversion --- enzyme induction --- Alternaria mycotoxins --- combinatory effects --- combined toxicity --- co-occurrence --- bioactive compounds --- fungi --- phaseolinone --- LC/MS --- soybean --- charcoal rot disease --- root infection mechanism --- Fusarium species --- toxigenic profile --- mycotoxin migration --- sweet pepper --- fungal disease --- fumonisin --- human exposure --- maize products --- botryodiplodin --- root toxicity --- Macrophomina phaseolina --- hydroponic culture --- AMF1 --- infant formulae --- estimated daily intake --- carcinogenic risk index --- Monterrey (Mexico) --- T-2 toxin --- HT-2 toxin --- deoxynivalenol (DON) --- enniatin B (EnnB) --- size sorting --- unprocessed cereals --- Atlantic salmon --- zebrafish --- liquid chromatography high-resolution mass spectrometry --- mycotoxins --- phytoestrogens --- plant-based feed --- rice --- sterigmatocystin --- STC --- deoxynivalenol --- DON --- growing season --- azoxystrobin --- fungicide --- Fumonisins --- Fusarium spp. --- food contamination --- health issues --- secondary metabolites --- Aflatoxins --- binding --- food safety --- biocontrol --- food discipline --- ergot alkaloids --- ergochromes --- secalonic acid --- cereals --- tetrahydroxanthones --- Claviceps --- aflatoxin --- mycotoxin --- black soldier fly --- BSFL --- Hermetia illucens --- S9 fraction --- cytochrome P450 --- metabolic conversion --- enzyme induction --- Alternaria mycotoxins --- combinatory effects --- combined toxicity --- co-occurrence --- bioactive compounds --- fungi --- phaseolinone --- LC/MS --- soybean --- charcoal rot disease --- root infection mechanism --- Fusarium species --- toxigenic profile --- mycotoxin migration --- sweet pepper --- fungal disease --- fumonisin --- human exposure --- maize products --- botryodiplodin --- root toxicity --- Macrophomina phaseolina --- hydroponic culture --- AMF1 --- infant formulae --- estimated daily intake --- carcinogenic risk index --- Monterrey (Mexico) --- T-2 toxin --- HT-2 toxin --- deoxynivalenol (DON) --- enniatin B (EnnB) --- size sorting --- unprocessed cereals
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