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Pharmacokinetics --- Drug Interactions --- Pharmacogenetics --- Drug Toxicity --- Drugs --- Metabolism --- Drugs - Metabolism

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Pharmacology. --- Drugs --- Pharmacologie --- Médicaments --- Metabolism. --- Métabolisme --- Pharmacology --- Metabolism --- PHARMACOLOGY --- 615 --- Drug metabolism --- Pharmacokinetics --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Farmacologie. Farmaceutische wetenschappen --- Physiological effect --- Textbooks & monographs 1891-2000 --- Textbooks & monographs 1891-2000. --- Médicaments --- Métabolisme --- Drugs - Metabolism

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In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Pharmacokinetics --- Drugs --- Physiological effect --- Metabolism --- Medicine. --- Pharmacy. --- Pharmacology. --- Biochemistry. --- Biomedicine. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Pharmaceutical Preparations --- Drug Interactions --- Pharmacology --- metabolism --- Toxicology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Medicine --- Materia medica --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Pharmacy --- Composition --- Drug kinetics --- Kinetics, Drugs --- Chemical kinetics --- Kinetics --- Pharmacokinetics - Handbooks, manuals, etc. --- Drugs - Physiological effect - Handbooks, manuals, etc. --- Drugs - Metabolism - Handbooks, manuals, etc. --- Pharmaceutical Preparations - metabolism - handbooks --- Pharmacokinetics - handbooks --- Drug Interactions - Handbooks. --- Pharmacology - Handbooks.

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Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver, and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.     Yuichi Sugiyama is head of Sugiyama Laborator at RIKEN Innovation Center, RIKEN Research Cluster for Innovation in Yokohama, Japan, and previously professor in the Department of Molecular Pharmacokinetics at the University of Tokyo from 1991 through to his retirement from the University in 2012. He is coauthor of more than 580 publications in international journals as well as 270 book chapters and review articles. His work is internationally recognized by prestigious awards, including AAPS Distinguished Pharmaceutical Scientist Award (2003), FIP Hoest Madsen Gold Medal (2009), “Medal with Purple Ribbon” given by the government in 2010, and the B. Brodie Award from ASPET (2012). Professor Sugiyama has been ranked as the top-cited scientist in the field of Pharmacology & Toxicology (1997–2007). He served as the chairman of the Board of Pharmaceutical Sciences in FIP and was also the president of both the International Society for the Study of Xenobiotics (ISSX) and Japanese Society for Xenobiotic Metabolism and Disposition (JSSX).   Bente Steffansen is associate professor in transporters in ADME at the Faculty of Health and Medical Sciences, University of Copenhagen. She graduated with MSc (pharm) in 1989 from the Royal Danish School of Pharmacy and obtained her PhD in 1994 under the Danish Research Academy within the field of prodrug design aimed for improved drug delivery. Dr. Steffansen has published more than 60 research articles, edited a book, and serves as the program director for pharmaceutical education at the University of Copenhagen. She is a member of the Chemical Committee under the National Pharmacopeia Board and a member of the European BioSim network of excellence.

Drugs -- Metabolism. --- Pharmacokinetics. --- Carrier proteins --- Pharmacology --- Drug development --- Drugs --- Proteins --- Kinetics --- Pharmacological Processes --- Investigative Techniques --- Biological Science Disciplines --- Amino Acids, Peptides, and Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Pharmacological Phenomena --- Biochemical Phenomena --- Disciplines and Occupations --- Physiological Phenomena --- Chemicals and Drugs --- Chemical Phenomena --- Phenomena and Processes --- Drug Discovery --- Carrier Proteins --- Drug Interactions --- Pharmacokinetics --- Physiology --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Design --- Carrier proteins. --- Drug development. --- Membrane proteins. --- Physiological transport. --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Development of drugs --- New drug development --- Binding proteins --- Transport proteins --- Development --- Medicine. --- Pharmaceutical technology. --- Biomedicine. --- Pharmaceutical Sciences/Technology. --- Biomedicine general. --- Membranes (Biology) --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacy --- Biological transport --- Protein binding --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.