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book (4)

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Book
Cardio-oncology : management of toxicities in the era of immunotherapy
Author:
ISBN: 3030977439 3030977447 Year: 2022 Publisher: Cham, Switzerland : Springer Nature Switzerland AG,

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Cardiac safety of noncardiac drugs : practical guidelines for clinical research and drug development
Authors: ---
ISBN: 1280359366 9786610359363 1592598846 158829515X 1617376124 Year: 2005 Publisher: Totowa, N.J. : Humana Press,

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Although it is relatively easy to determine the efficacy of a new drug, it is difficult to establish its safety when administered to millions of patients with multifaceted diseases, co-morbidities, sensitivities, and multiple drug use. In Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development, basic and clinical researchers from industry and academia detail the preclinical, clinical, and regulatory principles currently used to assess the cardiac safety of new drugs from their effects on the electrocardiogram (ECG). The authors explain the parameters of cardiac safety at all stages of clinical research and drug development, including both the preclinical and pharmacogenomic aspects generally and the clinical methodologies and technical aspects for investigational drugs based on cardiac repolarization, as defined by the duration of the QTc interval. Additional chapters comprehensively review the application of electrocardiology in clinical research, demonstrating the fundamentals of ECG interpretation in clinical trials, the statistical analysis plans for ECG data obtained in formal clinical trials, and the practical interpretation of the results. Highlights include practical guidance on how to conduct a thorough ECG Trial in New Drug Development, how to use new ECG and web-based technology in clinical research, and how to follow the new FDA requirements for ECG submissions. Authoritative and up-to-date, Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development offers clinical researchers in industry and academia expert practical advice on establishing their product's cardiac safety, predicting regulatory actions, and getting it successfully to market.


Book
Cellular and molecular pathobiology of cardiovascular disease
Authors: --- ---
ISBN: 0124055257 0124052061 1306270545 9780124055254 9781306270540 9780124052062 9780124052062 Year: 2014 Publisher: London : Academic Press,

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Focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine.--


Periodical
Cardiovascular toxicology.
Author:
ISSN: 15590259 15307905 Year: 2001 Publisher: Totowa, N.J. : [Heidelberg] : Humana Press, Springer

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Book
Cardiovascular toxicity and therapeutic modalities targeting cardio-oncology : from basic research to advanced study
Authors: ---
ISBN: 0323904610 0323904629 9780323904629 9780323904612 Year: 2022 Publisher: London, England ; San Diego, California ; Cambridge, Massachusetts : Academic press,

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Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more. [...] Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications—arrhythmias, heart failure, and even death.

Keywords

Cardiovascular toxicology. --- Cardiotoxicity. --- Drug-Related Side Effects and Adverse Reactions. --- Antineoplastic Agents. --- Radiotherapy --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agent, Cancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drug, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Adverse Drug Event --- Adverse Drug Reaction --- Drug Side Effects --- Drug Toxicity --- Side Effects of Drugs --- Toxicity, Drug --- Adverse Drug Events --- Adverse Drug Reactions --- Drug Event, Adverse --- Drug Events, Adverse --- Drug Reaction, Adverse --- Drug Reactions, Adverse --- Drug Related Side Effects and Adverse Reactions --- Drug Side Effect --- Drug Toxicities --- Effects, Drug Side --- Reactions, Adverse Drug --- Side Effect, Drug --- Side Effects, Drug --- Toxicities, Drug --- Drug Therapy --- Pharmaceutical Preparations --- Contraindications, Drug --- Drug Interactions --- Clinical Trials, Phase IV as Topic --- Cardiac Toxicity --- Cardiac Toxicities --- Cardiotoxicities --- Toxicity, Cardiac --- Cardiovascular toxicity --- Toxicology --- adverse effects. --- adverse effects --- toxicity --- Heart --- Effect of drugs on. --- Cardiovascular pharmacology --- Drug effects --- Cardiotoxicity --- Drug-Related Side Effects and Adverse Reactions --- Antineoplastic Agents --- adverse effects ǂ0 (DNLM)D011878Q000009

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