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Leukemia, Myelogenous, Chronic, BCR-ABL positive --- immunology --- physiopathology

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European Union --- research projects --- evaluation. --- evaluation --- Standardizing --- Measurement --- experimentation. --- experimentation --- Quality --- Biometry --- Analytical methods --- Programme cadre --- Bcr --- Smt --- M et t

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Patient outcomes remain poor for many cancers despite improvements in treatments and new molecular-targeted biomedicines for certain cancer types or subtypes. Dose-limiting toxicity, a narrow therapeutic index, and the development of resistance to traditional anti-cancer agents are well-established. It is apparent that inherent and acquired drug resistance are major challenges with molecular-targeted agents and that on- as well as off-target side effects can still occur. Other issues include drug metabolism by the body and safely supplying a sufficient amount of active drug to the tumor cells. There is a clear and urgent need for new molecular targets and drugs that specifically target cancer cells in different ways to existing approved drugs. This book, through a collection of eight research articles and two review articles from the Biomedicines themed Special Issue ‘Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action’, provides a snapshot of some of the diverse and exciting research approaches being taken by the cancer research community in trying to address some of these therapeutic challenges.

Technology: general issues --- History of engineering & technology --- microtubule acetylation --- triple-negative breast cancer --- anti-cancer agent --- apoptosis --- K562 --- 8-hydroxydaidzein --- autophagy --- BCR-ABL --- MAPK --- NF-κB --- c-myc --- RNA interference --- siRNA --- oncogene --- gene silencing --- expression --- nanosystems --- Cytochrome P450 --- CYP1A1 --- CYP1B1 --- CYP2W1 --- breast cancer --- prodrug --- bioprecursor --- duocarmycin --- phortress --- AQ4N --- 5-FU resistance --- colorectal cancer --- drug repurposing --- Genomics of Drug Sensitivity in Cancer --- Connectivity Map --- anticancer drug --- B-lactam steroid alkylators --- synthetic lethality --- poly (ADP-ribose) polymerase inhibitors --- ovarian cancer --- hybrid steroidal alkylating agents --- migration --- invasion --- glioblastoma --- CCN1 --- mesenchymal–amoeboid transition --- biomarker --- HepG2 --- Huh7 --- isatin sulfonamides --- angiogenesis --- cancer hallmarks --- molecular docking --- EGFR tyrosine kinase inhibitor --- photon upconversion --- triplet-triplet annihilation --- in vivo imaging --- PLGA --- nanoparticles --- affibody molecule --- human epidermal growth factor receptor 3 (HER3) --- BxPC-3 --- emtansine --- DM1 --- albumin binding domain --- affibody drug conjugate (AffiDC) --- n/a --- mesenchymal-amoeboid transition

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La Cour de justice de l’Union européenne est aujourd’hui l’institution judiciaire qui fait l’objet de toutes les attentions de la part du monde scientifique. Elle serait même, derrière la Cour suprême des États-Unis, l’organe judiciaire le plus étudié au monde. Cet ouvrage propose de démontrer que la Cour de justice de l’Union européenne est une juridiction constitutionnelle.Tout d’abord, la Cour de justice de l’Union européenne dispose d’une légitimité qui peut être qualifiée de constitutionnelle tant au regard de ses composantes humaines que de sa procédure. La procédure de nomination ainsi que l’office des membres de la Cour de justice de l’Union européenne caractérisent sa légitimité constitutionnelle subjective. L’étude des règles de procédure amène au constat que le procès devant la Cour de justice de l’Union européenne a les attraits d’un procès constitutionnel. Elles caractérisent la légitimité constitutionnelle objective de la Cour de justice de l’Union européenne.La Cour de justice dispose ensuite d’une compétence qui peut être qualifiée de constitutionnelle car elle exerce des attributions qui sont traditionnellement dévolues au juge constitutionnel.Ceci se vérifie tout d’abord dans le contrôle de la régularité des normes étatiques et européennes au droit de l’Union européenne lato sensu qui évoque le contrôle de constitutionnalité des lois devant les juridictions constitutionnelles nationales. Cela se vérifie, ensuite, dans le contrôle de la répartition horizontale et verticale des compétences qu’exerce le juge de l’Union européenne et qui constitue l’une des attributions des juges constitutionnels dans les États fédéraux ou régionaux. Cela se vérifie, enfin, à l’aune de la garantie des droits fondamentaux, que le juge de l’Union européenne veille à préserver au sein de l’ordre juridique dont il est l’interprète authentique.

European law --- Public law. Constitutional law --- European Union --- E-books --- Juges --- Procédure (droit européen) --- Sélection et nomination --- Union européenne --- Charte des droits fondamentaux. --- Constitutional law. --- Law --- Droit constitutionnel (droit européen) --- Droit européen et droit interne. --- Sélection et nomination. --- Court of Justice of the European Union. --- Union européenne. --- BPB2108 --- STRADALEX --- Cour de justice de l'Union européenne --- juridiction constitutionnelle --- compétence des États membres --- norme européenne --- contrôle de constitutionnalité --- alkotmányossági normakontroll --- jogszabályok alkotmányossága --- ústavnost zákonů --- ústavnosť zákonov --- kushtetutshmëri e ligjeve --- ústavnost právního předpisu --- loves forfatningsmæssighed --- контрола на уставноста на општите акти --- ustavnost zakona --- konstitucionālā uzraudzība --- törvények alkotmányossága --- уставност на закон --- контрола на законитоста на управните акти --- constitucionalidad de las leyes --- előzetes normakontroll --- ústavní kontrola --- constituționalitatea legilor --- constitutionnalité des lois --- costituzionalità delle leggi --- συνταγματικότητα των νόμων --- grundlagsenlighet --- utólagos normakontroll --- grondwettigheid van de wet --- lakien perustuslainmukaisuus --- законитост на подзаконските акти --- įstatymų atitiktis konstitucijai --- tiesību aktu atbilstība konstitūcijai --- ústavní stížnost --- constitucionalidade das leis --- constitutionality of laws --- Verfassungsmäßigkeit der Gesetze --- seaduste põhiseaduslikkus --- control al constituţionalităţii --- verifica di costituzionalità --- kontroll av författningsenlighet --- controlo de constitucionalidade --- control of constitutionality --- контрола уставности --- контрол на конституционост --- kontroll tal-kostituzzjonalità --- konstitucingumo kontrolė --- toezicht op de grondwettigheid --- põhiseaduslikkuse kontroll --- kontrola ustavnosti --- kontroll i kushtetutshmërisë --- control de constitucionalidad --- alkotmányosság vizsgálata --- kontrola konstytucyjności --- presoja ustavnosti --- kontrola ústavnosti --- Kontrolle der Verfassungsmäßigkeit --- kontrol af overensstemmelse med forfatningen --- контрола на уставноста --- έλεγχος συνταγματικότητας --- control constituțional --- rialú na bunreachtúlachta --- perustuslaillisuuden valvonta --- konstitucionālisma kontrole --- gemenskapsnorm --- euronorme --- норми на Заедницата --- komunitární norma --- Kopienas standarts --- Community standard --- BCR --- ühenduse standard --- euronorm --- fællesskabsnorm --- κοινοτικό πρότυπο --- norme communautaire --- közösségi szabvány --- yhteisön standardi --- Eironorma --- Serviço Comunitário de Referência --- Euronorm --- norma comunitaria --- norma Zajednice --- европски норми --- Bendrijos standartas --- standard i Komunitetit --- norma Spoločenstva --- communautaire norm --- norma comunitária --- euronorma --- standard comunitar --- Europos norma --- norma europea --- eurooppalainen standardi --- European standard --- standard european --- Europos standartas --- Eiropas standarts --- ευρωπαϊκό πρότυπο --- europeisk standard --- európska norma --- europæisk norm --- standard Ewropew --- caighdeán Eorpach --- evropski standard --- európai szabvány --- standard europian --- europäische Norm --- европейски стандарт --- norma europejska --- norma europeia --- Euroopa standard --- Europese norm --- европски стандард --- evropská norma --- europska norma --- споделена надлежност меѓу Унијата и земјите членки --- Zuständigkeit zur Unterstützung --- спомагателно правомощие --- podpůrná pravomoc --- podporná právomoc --- podporna pristojnost --- competencia de apoyo --- competência de apoio --- compétence d'appui --- stödjande befogenheter --- ondersteunende bevoegdheid --- kompetencje w zakresie udzielania wsparcia --- papildomoji kompetencija --- supporting competence --- исклучива надлежност на земјите членки --- understøttende kompetence --- υποστηρικτικές αρμοδιότητες --- tagállamok hatásköre --- kompetenza ta' appoġġ --- competenza di sostegno --- competență complementară --- kompletterande befogenheter --- bevoegdheid van de Lid-Staten --- atbalsta kompetence --- toetav pädevus --- kiegészítő hatáskör --- Zuständigkeit der Mitgliedstaaten --- pristojnost držav članic --- надлежност на земјите членки --- medlemsstaternas behörighet --- jäsenvaltioiden toimivalta --- competencias de los Estados miembros --- kompetenza tal-Istati Membri --- competenza degli Stati membri --- příslušnost členských států --- medlemsstatskompetence --- αρμοδιότητα των κρατών μελών --- právomoci členských štátov --- kompetenca të Shteteve Anëtare --- valstybių narių kompetencija --- competence of the Member States --- надлежност држава чланица --- tagállami hatáskör --- inniúlacht na mBallstát --- bevoegdheid van de lidstaten --- competența statelor membre ale Uniunii Europene --- competência dos Estados-Membros --- liikmesriikide pädevus --- компетенции на държави членове --- dalībvalstu kompetence --- kompetencje państw członkowskich --- nadležnost država članica --- Συνταγματικό Συμβούλιο --- Tribunal Constitucional --- författningsråd --- forfatningsdomstol --- Tribunal de Garantías Constitucionales --- Consejo Constitucional --- alkotmányügyi tanács --- cour constitutionnelle --- põhiseaduslik kohus --- Conseil constitutionnel --- Satversmes tiesa --- Staatsraad --- Verfassungsgericht --- corte costituzionale --- Constitutioneel Hof --- qorti kostituzzjonali --- συνταγματικό δικαστήριο --- giurisdizione costituzionale --- ustavno sodišče --- ústavný súd --- ústavní soud --- författningsdomstol --- constitutional court --- Curte Constituțională --- alkotmánybíróság --- valtiosääntötuomioistuin --- forfatningsjurisdiktion --- konstitucionālā tiesa --- уставни суд --- konstitucinis teismas --- ustavni sud --- sądownictwo konstytucyjne --- gjykatë kushtetuese --- jurisdição constitucional --- konstitutsioonikohus --- cúirt bhunreachtúil --- уставен суд --- constitutionele rechtspraak --- конституционен съд --- Verfassungsgerichtsbarkeit --- jurisdicción constitucional --- TT --- SD --- Sud EZ-a --- Tribunal de Justiça das Comunidades Europeias --- yhteisötuomioistuin --- EB --- Gerichtshof der Europäischen Union (Organ) --- Curtea de Justiţie a Uniunii Europene (instituţie) --- Evropský soudní dvůr --- Sud Europske unije (institucija) --- EK Tiesa --- Δικαστήριο ΕΚ --- Euroopa Kohus --- EST --- Court of Justice of the European Union (institution) --- Az Európai Unió Bírósága (intézmény) --- Δικαστήριο της Ευρωπαϊκής Ένωσης (θεσμικό) --- Euroopa Liidu Kohus (institutsioon) --- Súdny dvor ES --- Δικαστήριο των Ευρωπαϊκών Κοινοτήτων --- Cúirt Bhreithiúnais an Aontais Eorpaigh (institiúid) --- Community court --- Gemeinschaftsgerichtsbarkeit --- EKT --- Europees Hof van Justitie --- TJCE --- Eiropas Kopienu Tiesa --- Domstolen --- Hof van Justitie van de Europese Gemeenschappen --- a Bíróság --- jurisdicción comunitaria --- EuGH --- De Europæiske Fællesskabers Domstol --- TS --- giurisdizione comunitaria --- jurisdição comunitária --- Cour de justice des Communautés européennes --- Soudní dvůr ES --- Tribunal de Justicia de la Unión Europea (institución) --- Eiropas Savienības Tiesa (iestāde) --- Európai Bíróság --- EY:n tuomioistuin --- Euroopan unionin tuomioistuin (toimielin) --- Curte comunitară --- Corte di giustizia CE --- CJUE --- Soudní dvůr Evropských společenství --- HvJEG --- Cour de justice de l’Union européenne (institution) --- HvJ --- EU-Bíróság --- Tribunal de Justiça CE --- Gerichtshof der Europäischen Gemeinschaften --- Tribunal de Justiça Europeu --- Tribunal de Justicia CE --- Curtea Europeană de Justiție --- Europäischer Gerichtshof --- Cúirt Bhreithiúnais na gComhphobal Eorpach --- Court of Justice of the European Communities --- ΔΕΚ --- EG-Gerichtshof --- SEU --- CJEC --- il-Qorti tal-Ġustizzja tal-Unjoni Ewropea (istituzzjoni) --- Sud EU-a --- Europos Bendrijų Teisingumo Teismas --- EF-Domstolen --- EBTT --- gemenskapsdomstol --- Tribunal de Justiça da União Europeia (instituição) --- juridiction communautaire --- Hof van Justitie van de Europese Unie (instelling) --- CJCE --- Ευρωπαϊκό Δικαστήριο --- il-Qorti tal-Ġustizzja tal-Komunitajiet Ewropej --- CGUE --- Europeiska unionens domstol (institution) --- European Court of Justice --- Curtea de Justiție a Comunităților Europene --- CGCE --- Sodišče Evropske unije (institucija) --- Съд на ЕО --- SDES --- Corte di giustizia europea --- Corte di giustizia dell’Unione europea (istituzione) --- Euroopa Ühenduste Kohus --- Sodišče Evropskih skupnosti --- QĠUE --- Euroopan yhteisöjen tuomioistuin --- EU-Domstolen --- Súd Spoločenstva --- Europejski Trybunał Sprawiedliwości --- κοινοτικό δικαστήριο --- Europeiska gemenskapernas domstol --- Trybunał Sprawiedliwości Unii Europejskiej (instytucja) --- Съд на Европейския съюз (институция) --- yhteisöjen tuomioistuin --- Bendrijos teismas --- Soudní dvůr Evropské unie (orgán) --- Europos Teisingumo Teismas --- EC Court of Justice --- SES --- EF-domsmyndighed --- Europos Sąjungos Teisingumo Teismas (institucija) --- EK Bíróság --- ΔΕΕ --- Съд на Европейските общности --- Tribunal de Justicia Europeo --- CJEU --- Kopienas Tiesa --- TJUE --- Eiropas Tiesa --- Cour de justice européenne --- Суд ЕЗ --- EU-domstolen --- Trybunał Sprawiedliwości Wspólnot Europejskich --- Den Europæiske Unions Domstol (institution) --- Tiesa Eiropai --- az Európai Közösségek Bírósága --- Sodišče ES --- Tribunal de Justicia de las Comunidades Europeas --- Sud Europskih zajednica --- СПЕУ --- CBCE --- Hof van Justitie EG --- Corte di giustizia delle Comunità europee --- Európsky súdny dvor --- Súdny dvor Európskej únie (inštitúcia) --- EG-domstolen --- Súdny dvor Európskych spoločenstiev --- EB Teisingumo Teismas --- Gjykata e Drejtësisë e Bashkimit Europian --- il-Qorti tal-Ġustizzja tal-Unjoni Ewropea --- Суд правде Европске уније --- Soudní dvůr Evropské unie --- Cúirt Bhreithiúnais an Aontais Eorpaigh --- Суд на правдата на Европската Унија --- Tribunal de Justiça da União Europeia --- Trybunał Sprawiedliwości Unii Europejskiej --- az Európai Unió Bírósága --- Den Europæiske Unions Domstol --- Súdny dvor Európskej únie --- Eiropas Savienības Tiesa --- Court of Justice of the European Union --- Sodišče Evropske unije --- Euroopan unionin tuomioistuin --- Hof van Justitie van de Europese Unie --- Tribunal de Justicia de la Unión Europea --- Europeiska unionens domstol --- Sud Europske unije --- Gerichtshof der Europäischen Union --- Δικαστήριο της Ευρωπαϊκής Ένωσης --- Curtea de Justiție a Uniunii Europene --- Corte di giustizia dell'Unione europea --- Europos Sąjungos Teisingumo Teismas --- Съд на Европейския съюз --- Euroopa Liidu Kohus --- contrôle de constitutionnalité --- Cour de justice de l'Union européenne --- compétence des États membres --- norme européenne