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ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- AFRICA --- ASIA --- CHECKLISTS --- DISTRIBUTION --- EUROPE --- TAXONOMY --- ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- ASTRAGALUS --- AFRICA --- ASIA --- CHECKLISTS --- DISTRIBUTION --- EUROPE --- TAXONOMY
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ASW Western Asia --- flora --- Iran --- Papilionaceae --- Astragalus --- Flora --- Guide books
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LEG Leguminosae --- Astragalus --- Leguminosae --- botanical drawings --- distribution maps --- monographs --- systematics
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ASW Western Asia --- Astragalus --- Papilionaceae --- Western Asia --- flora --- FLORA --- GUIDE BOOKS --- IRAN
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acquisitions 2015.05-06 --- flora --- Iran --- Papilionaceae --- Astragalus --- Flora --- Guide books
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flora --- Central Asia --- China --- Mongolia --- Leguminosae --- Astragalus --- keys --- drawings --- distribution maps --- Oxytropis --- PLANT COLLECTIONS --- ASIA
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Élevage de volailles --- poultry farming --- Promoteur de croissance animale --- animal growth promoters --- Probiotique --- probiotics --- Biosynthèse --- Biosynthesis --- Immunité --- immunity --- Lentinula edodes --- Polyholoside --- Polysaccharides --- Antimicrobien --- Antimicrobials --- Eimeria tenella --- 636.5 --- 636.086.7 --- 636.087.7 --- Poultry --- Other vegetable foodstuffs. Foliage --- Additives. Stimulants. Feeding supplements (salt, lime, vitamins, proteins etc.) --- Theses --- 636.087.7 Additives. Stimulants. Feeding supplements (salt, lime, vitamins, proteins etc.) --- 636.086.7 Other vegetable foodstuffs. Foliage --- 636.5 Poultry --- Prebiotique --- Astragalus membranacea --- Avian mycoplasma
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In the biochemical reactions that take place within all living beings, species called free radicals are generated. Denham Harman, in his study on the origin and evolution of life (Harman, 2001), proposes that these species are amongst the causes of the origin of life on our planet. Oxygen is a molecule that provides the primary source of energy in aerobic organisms and therefore is key to the development and evolution of life. On the one hand, it gives rise to life; on the other, due to its ability to form different free radicals, it is capable of damaging essential structures for development. To combat these radicals, our biological systems have developed antioxidant defenses. However, when the balance between free radicals and antioxidant defenses is broken in favor of the former, a phenomenon called oxidative stress occurs, which ends up damaging molecules such as DNA, proteins, carbohydrates, and lipids (Sies, 1983) (Halliwell and Gutteridge, 1985). This phenomenon is implicated both in the development of diseases and in their progression. In addition, inflammation phenomena are also involved in most pathologies, which, although they are essential for tissue repair and immunity, turn against our bodies when they become excessively active. For these reasons, in this special edition we showcase an extensive knowledge of the effects of oxidative stress and inflammation both in diseases such as aging, or for its role in health.
Public health & preventive medicine --- diospyrin --- lipopolysaccharide --- anti-inflammation --- macrophages --- nitric oxide --- cytokine --- calcium --- CHOP --- Fas --- p38 MAPK --- Astragalus mongholicus Bunge --- danazol --- telomere --- telomerase --- aging --- diabetic kidney disease --- oxidative stress --- redox imbalance --- hyperimmunized milk --- exercise --- inflammation --- intestinal permeability --- acute respiratory distress syndrome --- antiplatelet --- aspirin --- therapy --- gender --- membrane erythrocyte --- hydroperoxides --- biomarker --- DPPP --- DPH --- TMA --- cardiovascular disease --- data analysis --- precision–recall --- Mediterranean diet --- Oriental diet --- nutrition --- polyphenols --- microbiota --- health --- n-3 PUFAs --- endogenous antioxidants --- anti-inflammatory response --- cardiovascular diseases --- dry eye syndrome --- corneal damage --- tear lipidome --- 5-lipoxigenase --- leukotriene B4 --- prostaglandins --- dimethyl sulfoxide --- zileuton --- air pollution --- soot --- particulate matter --- lung inflammation --- functional groups --- microglia --- porcine liver decomposition product --- lysophospholipids --- mild cognitive impairment --- dementia --- neuroinflammation --- cytokines --- oxygen reactive species --- caloric restriction --- oxidative balance --- adiponectin --- plasma --- white adipose tissue --- experimental model --- anti-inflammatory diets --- inflammatory response --- chronic inflammation --- low grade chronic inflammation --- inflammatory models --- cyclophosphamide --- doxorubicin --- docetaxel --- paclitaxel --- n/a --- precision-recall
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Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome.
Humanities --- Social interaction --- DAPK1 --- SUMO --- SENP --- protein degradation --- post-translational modification --- amphibian Bowman-Birk inhibitor --- Tat peptide --- molecular cloning --- antifungal --- drug design --- protease inhibitor --- natural-based compound --- anticancer therapy --- lung cancer --- survivin --- apoptosis --- STAT3 --- colorectal cancer --- orientin --- cell cycle arrest --- Bcl-2 family proteins --- Astragalus membranaceus --- insulin --- PI3K --- AKT --- PPARγ --- PDX-1 --- Petasites japonicus --- Asteraceae --- lignan --- anti-inflammation --- NO --- PGE2 --- iNOS --- COX-2 --- molecular docking --- peptides --- kynurenines --- binding affinity --- μ-opioid receptor --- pharmacophore --- G-protein activation --- fucoidan --- PLGA --- docetaxel --- drug delivery system --- anticancer therapy/cancer treatment --- hIAPP --- amyloidogenesis --- insulin granules --- endoplasmic reticulum --- anionic lipids --- F23R variant --- β-sheet transitions --- β-cell cytotoxicity --- unfolded protein response --- pomegranate --- punicalagin --- tannins --- gingiva --- fibroblasts --- antioxidant --- wound healing --- branched-chain fatty acids --- Conidiobolus heterosporus --- peroxisome proliferator-activated receptor α --- lipid metabolism --- fatty acid oxidation --- hepatocyte --- DAPK1 --- SUMO --- SENP --- protein degradation --- post-translational modification --- amphibian Bowman-Birk inhibitor --- Tat peptide --- molecular cloning --- antifungal --- drug design --- protease inhibitor --- natural-based compound --- anticancer therapy --- lung cancer --- survivin --- apoptosis --- STAT3 --- colorectal cancer --- orientin --- cell cycle arrest --- Bcl-2 family proteins --- Astragalus membranaceus --- insulin --- PI3K --- AKT --- PPARγ --- PDX-1 --- Petasites japonicus --- Asteraceae --- lignan --- anti-inflammation --- NO --- PGE2 --- iNOS --- COX-2 --- molecular docking --- peptides --- kynurenines --- binding affinity --- μ-opioid receptor --- pharmacophore --- G-protein activation --- fucoidan --- PLGA --- docetaxel --- drug delivery system --- anticancer therapy/cancer treatment --- hIAPP --- amyloidogenesis --- insulin granules --- endoplasmic reticulum --- anionic lipids --- F23R variant --- β-sheet transitions --- β-cell cytotoxicity --- unfolded protein response --- pomegranate --- punicalagin --- tannins --- gingiva --- fibroblasts --- antioxidant --- wound healing --- branched-chain fatty acids --- Conidiobolus heterosporus --- peroxisome proliferator-activated receptor α --- lipid metabolism --- fatty acid oxidation --- hepatocyte
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The Special issue "Biological and Pharmacological Activity of Plant Natural Compounds II" is continuing the intriguing research on the use of natural plant products. The second edition follows the aim of the first one.
Medicine --- Pharmacology --- Bergenia species --- botanical description --- traditional uses --- phytochemistry --- pharmacology --- anti-urolithiatic activity --- bergenin --- Flaxseed oil --- linusorb B3 --- anti-cancer --- apoptosis --- actin polymerization --- Src --- glioblastoma --- chlorogenic acid --- coffee --- cyclooxygenase --- espresso --- instant coffee --- platelet aggregation --- Rubia tinctorum L. --- antioxidants --- polyphenols --- ethylene glycol --- urolithiasis --- histophatology --- Saccharomyces cerevisiae --- β-glucan --- antimicrobial and anticancer activities --- detoxification ability --- immunomodulatory effect --- Aquilaria sinensis --- pheophorbide A --- MMP-2 --- MMP-9 --- HT-1080 --- advanced glycation end product (AGE) --- oxidative stress --- epithelial to mesenchymal transition --- AGE-inhibitor --- swertiamarin --- diabetic nephropathy --- astragaloside IV --- Astragalus membranaceus --- huang qi --- Astragali Radix --- liver --- liver regeneration --- 70% partial hepatectomy --- proliferation --- rat --- memory --- object recognition --- Ginkgo biloba --- dorsal hippocampus formation --- brain-derived neurotrophic factor --- Diclofenac --- γ-lactone --- nano-emulsion --- methylcellulose --- Ostrich oil --- Struthio camelus --- Caenorhabditis elegans --- leaf extract --- neuroprotection --- antioxidant activity --- DAF-16 --- Clerodendrum infortunatum --- terpenoids --- phenylpropanoids --- antidiabetic --- breast cancer --- Combretum indicum L. --- antidiabetic activity --- histopathology --- UPLC-QTOF/ESI-MS --- network pharmacology --- Biebersteinia heterostemon --- galegine --- hypotensive --- toxicity --- Sage --- Salvia officinalis --- cytotoxicity --- hepatoprotection --- MDA --- TAOxC --- MCF-7 --- HeLA cells --- HepG-2 cells --- Peganum harmala --- anti-inflammatory activity --- antioxidant --- LC-ESI-MS/MS --- traditional medicine --- rheumatoid arthritis --- rosmanol --- carnosol --- Callicarpa longissima --- TLR4/NF-κB/MAPK --- synergistic effect --- diabetes mellitus --- anti-diabetic drugs --- monoterpenes --- Bergenia species --- botanical description --- traditional uses --- phytochemistry --- pharmacology --- anti-urolithiatic activity --- bergenin --- Flaxseed oil --- linusorb B3 --- anti-cancer --- apoptosis --- actin polymerization --- Src --- glioblastoma --- chlorogenic acid --- coffee --- cyclooxygenase --- espresso --- instant coffee --- platelet aggregation --- Rubia tinctorum L. --- antioxidants --- polyphenols --- ethylene glycol --- urolithiasis --- histophatology --- Saccharomyces cerevisiae --- β-glucan --- antimicrobial and anticancer activities --- detoxification ability --- immunomodulatory effect --- Aquilaria sinensis --- pheophorbide A --- MMP-2 --- MMP-9 --- HT-1080 --- advanced glycation end product (AGE) --- oxidative stress --- epithelial to mesenchymal transition --- AGE-inhibitor --- swertiamarin --- diabetic nephropathy --- astragaloside IV --- Astragalus membranaceus --- huang qi --- Astragali Radix --- liver --- liver regeneration --- 70% partial hepatectomy --- proliferation --- rat --- memory --- object recognition --- Ginkgo biloba --- dorsal hippocampus formation --- brain-derived neurotrophic factor --- Diclofenac --- γ-lactone --- nano-emulsion --- methylcellulose --- Ostrich oil --- Struthio camelus --- Caenorhabditis elegans --- leaf extract --- neuroprotection --- antioxidant activity --- DAF-16 --- Clerodendrum infortunatum --- terpenoids --- phenylpropanoids --- antidiabetic --- breast cancer --- Combretum indicum L. --- antidiabetic activity --- histopathology --- UPLC-QTOF/ESI-MS --- network pharmacology --- Biebersteinia heterostemon --- galegine --- hypotensive --- toxicity --- Sage --- Salvia officinalis --- cytotoxicity --- hepatoprotection --- MDA --- TAOxC --- MCF-7 --- HeLA cells --- HepG-2 cells --- Peganum harmala --- anti-inflammatory activity --- antioxidant --- LC-ESI-MS/MS --- traditional medicine --- rheumatoid arthritis --- rosmanol --- carnosol --- Callicarpa longissima --- TLR4/NF-κB/MAPK --- synergistic effect --- diabetes mellitus --- anti-diabetic drugs --- monoterpenes
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