Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Phenomenology. --- Voice. --- Brazil. --- Altitude, Influence of. --- Papacy --- Phenomenology --- Phénoménologie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book reviews how severe oxygen deprivation affects biological systems - from the molecular to the ecological level. The contributing authors come from diverse regions of the world, which proves the interest in the academic analysis of oxygen deprivation. The diversity in the experimental approach scientists take, in order to understand the influence oxygen deprivation has on living systems, is apparent throughout this book. One of the presented ideas deals with the exploration and examination of the physiological, cellular and genetic characteristics of killifish embryos and nematodes exposed to anoxia. Furthermore, the book includes material on the mechanisms regulating hypoxia and anoxia tolerance and their implications of on human health issues. Finally, new methodologies to examine oxygen deprivation and the impact of human-related activities on oxygen level, within important ecological systems such as Lake Victoria, are presented. There is no doubt that the oxygen molecule is central to every stratum of biological systems.

Anoxemia. --- Anoxaemia --- Anoxhemia --- Anoxia --- Hypoxemia --- Hypoxia (Hematology) --- Oxygen deficiency in the blood --- Altitude, Influence of --- Asphyxia --- Oxygen --- Oxygen in the body --- Physiological effect --- Biogeography

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].

Altitude, Influence of. --- Mountain sickness. --- Altitude, Influence of --- Acclimatization --- Atmospheric pressure --- Medical climatology --- Physiological effect --- Physiology --- Sports medicine. --- Pneumology. --- Cardiology. --- Physiological, Cellular and Medical Topics. --- Sports Medicine. --- Pneumology/Respiratory System. --- Mathematics. --- Heart --- Internal medicine --- Athletic medicine --- Athletics --- Medicine and sports --- Physical education and training --- Sports --- Medicine --- Sports sciences --- Animal physiology --- Animals --- Biology --- Anatomy --- Diseases --- Medical aspects --- Biomathematics. --- Respiratory organs—Diseases. --- Mathematics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Anoxemia. --- Mountain sickness. --- Genomics. --- Genome research --- Genomes --- Molecular genetics --- Altitude, Influence of --- Anoxaemia --- Anoxhemia --- Anoxia --- Hypoxemia --- Hypoxia (Hematology) --- Oxygen deficiency in the blood --- Asphyxia --- Oxygen --- Oxygen in the body --- Research --- Physiological effect --- Anoxèmia

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude. In-depth and comprehensive chapters cover both the basic science and the clinical consequences of exposure to high altitude.  Genetic, cellular, organ and whole body system responses to high altitudes are covered and chapters discuss these effects on a wide range of diseases.  Expert authors provide insight into the care of patients with pre-existing medical conditions that fail in some cases to adapt as well as offer insights into how high altitude research can help critically ill patients.  High Altitude: Human Adaptation to Hypoxia is an important new volume that offers a window into greater understanding and more successful treatment of hypoxic human diseases.

Adaptation (Physiology) --- Altitude, Influence of. --- Anoxemia. --- Anoxaemia --- Anoxhemia --- Anoxia --- Hypoxemia --- Hypoxia (Hematology) --- Oxygen deficiency in the blood --- Compensation (Physiology) --- Plasticity (Physiology) --- Medicine. --- Human physiology. --- Internal medicine. --- Respiratory organs --- Medicine & Public Health. --- Pneumology/Respiratory System. --- Internal Medicine. --- Human Physiology. --- Diseases. --- Altitude, Influence of --- Asphyxia --- Oxygen --- Oxygen in the body --- Acclimatization --- Atmospheric pressure --- Medical climatology --- Ecophysiology --- Physiological effect --- Pneumology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Medicine, Internal --- Medicine --- Respiratory organs—Diseases.