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“Bioinformatics of Human Proteomics” discusses the development of methods, techniques and applications in the field of protein bioinformatics, an important direction in bioinformatics. It collects contributions from expert researchers in order to provide a practical guide to this complex field of study. The book covers the protein interaction network, drug discovery and development, the relationship between translational medicine and bioinformatics, and advances in proteomic methods, while also demonstrating important bioinformatics tools and methods available today for protein analysis, interpretation and predication. It is intended for experts or senior researchers in the fields of clinical research-related biostatistics, bioinformatics, computational biology, medicine, statistics, system biology, molecular diagnostics, biomarkers, or drug discovery and development. Dr. Xiangdong Wang works as a distinguished professor of Respiratory Medicine at Fudan University, Shanghai, China. He serves as Director of Biomedical Research Center, Fudan University Zhongshan Hospital and adjunct professor of Clinical Bioinformatics at Lund University, Sweden. His main research is focused on the role of clinical bioinformatics in the development of disease-specific biomarkers and dynamic network biomarkers, the molecular mechanism of organ dysfunction and potential therapies.      .

Bioinformatics. --- Genomics. --- Proteomics. --- Bioinformatics --- Proteomics --- Biological models --- Biology --- Biochemistry --- Amino Acids, Peptides, and Proteins --- Investigative Techniques --- Genomics --- Models, Theoretical --- Chemistry --- Chemicals and Drugs --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetics --- Natural Science Disciplines --- Disciplines and Occupations --- Methods --- Proteins --- Computational Biology --- Models, Biological --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Biology - General --- Data processing. --- Bio-informatics --- Biological informatics --- Life sciences. --- Molecular biology. --- Systems biology. --- Life Sciences. --- Computational Biology/Bioinformatics. --- Molecular Medicine. --- Systems Biology. --- Information science --- Computational biology --- Systems biology --- Data processing --- Molecular biology --- Medicine. --- Biological models. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biological systems --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules

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The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.

Life sciences. --- Human genetics. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Human Genetics. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Biosciences --- Sciences, Life --- Science --- Mitochondrial DNA --- Abnormalities. --- DNA abnormalities, Mitochondrial --- Mitochondrial DNA disorders --- Genetic disorders --- Mitochondrial pathology --- Cytology.

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This volume in the series, Translational Bioinformatics, provides an up-to-date overview of genomic approaches to asthma. By applying unbiased “-omics” combined with disease-focused and hypothesis-driven approaches, it enhances readers’ understanding of the asthma endotype. Furthermore, it elucidates how progress in -omics research, such as “genomic,” “transcriptomic,” “protomic,” and “metabolomic,” is applied in asthma, and reports on the related series of important breakthroughs in asthma development, classification, prevention and drug sensitivity. Also covering systems biology knowledge and methodologies, computational models and biostatistical methods to analyze big data, this book provides a valuable resource for scientists and researchers in the field of asthma and respiratory diseases.

Life sciences. --- Human physiology. --- Bioinformatics. --- Life Sciences. --- Human Physiology. --- Asthma. --- Bronchial asthma --- Bronchi --- Lungs --- Respiratory allergy --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Biosciences --- Sciences, Life --- Science --- Diseases --- Diseases, Obstructive --- Data processing --- Human biology --- Medical sciences --- Physiology --- Human body

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This book elucidates how genetic, biological and medical information can be applied to the development of personalized healthcare, medication and therapies. Focusing on aspects of the development of evidence-based approaches in bioinformatics and computational medicine, including data integration, methodologies, tools and models for clinical and translational medicine, it offers an essential introduction to clinical bioinformatics for clinical researchers and physicians, medical students and teachers, and scientists working with human disease-based omics and bioinformatics. Dr. Xiangdong Wang is a distinguished Professor of Medicine. He is Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Deputy Director of Shanghai Respiratory Research Institute, Director of Biomedical Research Center, Fudan University Zhongshan Hospital, Shanghai, China; Dr. Christian Baumgartner is a Professor of Health Care and Biomedical Engineering at Institute of Health Care Engineering with European Notified Body of Medical Devices, Graz University of Technology, Graz, Austria; Dr. Denis Shields is a Professor of Clinical Bioinformatics at Conway Institute, Belfield, Dublin, Ireland; Dr. Hong-Wen Deng is a Professor at Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, USA; Dr. Jacques S Beckmann is a Professor and Director of Section of Clinical Bioinformatics, Swiss Institute of Bioinformatics, Switzerland.

Medicine. --- Health informatics. --- Bioinformatics. --- Biomedicine. --- Biomedicine general. --- Health Informatics. --- Medical informatics. --- Clinical informatics --- Health informatics --- Medical information science --- Clinical sciences --- Medical profession --- Bio-informatics --- Biological informatics --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biology --- Information science --- Computational biology --- Systems biology --- Medicine --- Data processing --- Medical records --- Data processing. --- EHR systems --- EHR technology --- EHRs (Electronic health records) --- Electronic health records --- Electronic medical records --- EMR systems --- EMRs (Electronic medical records) --- Information storage and retrieval systems --- Medical care --- Biomedicine, general. --- Health Workforce