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This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.

NF-kappa B (DNA-binding protein). --- Oncology. --- Proteins --- Nuclear Proteins --- DNA-Binding Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- NF-kappa B --- Transcription Factors --- Medicine --- Health & Biological Sciences --- Oncology --- NF-kappa B (DNA-binding protein) --- Immunoglobulin enhancer-binding protein --- Kappa B enhancer binding protein --- NF-kB (DNA-binding protein) --- Nuclear factor kappa B --- Transcription factor NF-kB --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- DNA-binding proteins --- Transcription factors --- Tumors