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This book describes a specification, microarchitecture, VHDL implementation and evaluation of a SPARC v8 CPU with fine-grain multi-threading, called micro-threading. The CPU, named UTLEON3, is an alternative platform for exploring CPU multi-threading that is compatible with the industry-standard GRLIB package. The processor microarchitecture was designed to map in an efficient way the data-flow scheme on a classical von Neumann pipelined processing used in common processors, while retaining full binary compatibility with existing legacy programs.  Describes and documents a working SPARC v8, with fine-grain multithreading and fast context switch; Provides VHDL sources for the described processor; Describes a latency-tolerant framework for coupling hardware accelerators to microthreaded processor pipelines; Includes programming by example in the micro-threaded assembly language.    .

Mathematical physics. --- Computer architecture --- Simultaneous multithreading processors --- Field programmable gate arrays --- Engineering & Applied Sciences --- Electrical & Computer Engineering --- Electrical Engineering --- Computer Science --- Threads (Computer programs) --- Field programmable gate arrays. --- Threaded programming (Computer science) --- Threading (Computer programs) --- Field programmable logic arrays --- FPGAs --- Engineering. --- Microprocessors. --- Electronics. --- Microelectronics. --- Electronic circuits. --- Circuits and Systems. --- Processor Architectures. --- Electronics and Microelectronics, Instrumentation. --- Gate array circuits --- Programmable logic devices --- Computer programs

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This book presents valuable research results in the challenging field of systems (cyber)security. It is a reprint of the Information (MDPI, Basel) - Special Issue (SI) on Advanced Topics in Systems Safety and Security. The competitive review process of MDPI journals guarantees the quality of the presented concepts and results. The SI comprises high-quality papers focused on cutting-edge research topics in cybersecurity of computer networks and industrial control systems. The contributions presented in this book are mainly the extended versions of selected papers presented at the 7th and the 8th editions of the International Workshop on Systems Safety and Security—IWSSS. These two editions took place in Romania in 2019 and respectively in 2020. In addition to the selected papers from IWSSS, the special issue includes other valuable and relevant contributions. The papers included in this reprint discuss various subjects ranging from cyberattack or criminal activities detection, evaluation of the attacker skills, modeling of the cyber-attacks, and mobile application security evaluation. Given this diversity of topics and the scientific level of papers, we consider this book a valuable reference for researchers in the security and safety of systems.

Technology: general issues --- industrial control safety --- attack quantification --- common vulnerability scoring system --- attack tree --- distribution automation system --- Command and Control Citizen Security Center --- Command and Control Information System (C2IS) --- crime detection --- homeland security --- Android applications --- multi-threading --- operational semantics --- reverse engineering --- Smali+ --- cyber attack --- attacker --- attacker profile --- attacker behaviour --- metrics --- features --- attributes --- intelligent data analysis --- attack forecasting --- comparative review --- alert correlation --- attack evaluation --- attacker skill level --- attack prediction --- attack projection --- early-stage detection --- Bayesian network

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Programming --- Parallel programming (Computer science) --- Electronic data processing --- Threads (Computer programs) --- Programmation parallèle (Informatique) --- Traitement réparti --- Distributed processing. --- -Threads (Computer programs) --- 681.3*D4 --- Threaded programming (Computer science) --- Threading (Computer programs) --- Computer programs --- ADP (Data processing) --- Automatic data processing --- Data processing --- EDP (Data processing) --- IDP (Data processing) --- Integrated data processing --- Computers --- Office practice --- Computer programming --- Parallel processing (Electronic computers) --- Distributed processing --- Operating systems--See also {681.3*C} --- Automation --- 681.3*D4 Operating systems--See also {681.3*C} --- Programmation parallèle (Informatique) --- Traitement réparti --- Distributed computer systems in electronic data processing --- Distributed computing --- Distributed processing in electronic data processing --- Computer networks

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A growing interest has been devoted to the development of host systems for ionic and neutral species based on calixarenes. These cyclic oligomers show important host–guest properties, which has led to numerous applications in a broad range of fields, including organocatalysis, sensing, extraction and separation, and, more recently, biomedical applications. The relative ease of the functionalization of their upper and lower rims and the presence of a pre-organized cavity that is available in different sizes and conformations make calixarenes attractive building blocks for the construction of supramolecular assemblies. This book presents the most recent developments on the host–guest properties of calixarenes, as well as the new synthetic methods and applications.

Research & information: general --- thiosemicarbazone --- calix[4]arene --- metal complex --- X-ray structure --- antimicrobial --- anticancer --- copper --- supramolecular --- inclusion complex --- fluorescence --- sensor --- density functional theory --- calix[3]arenes --- metacyclophanes --- calixarene-analogous metacyclophanes --- inherent chirality --- host-guest chemistry --- dihomooxacalix[4]arenes --- naphthyl(thio)urea anion receptors --- alkylammonium hydrochlorides --- ditopic receptors --- chiral recognition --- NMR studies --- UV-Vis absorption studies --- fluorescence studies --- X-ray diffraction --- DFT calculations --- calixarene --- resorcinarene --- pillararene --- antibiotic --- fungicide --- biofilm inhibition --- calixarenes --- threading --- chirality --- barfate salts --- pseudorotaxane --- chiral axles --- chiral wheels. --- calixarene-like structure --- polyoxometalates --- nitronate --- crystal structure --- host–guest chemistry --- anion receptor --- anion --- sensors --- lanthanides --- UV–vis studies --- quantum yields --- lifetime measurements --- noncovalent synthesis --- hierarchical control --- calix[4]tubes --- metallo-porphyrins --- phthalimide derivatives --- conventional synthesis --- microwave irradiation --- ball milling --- NMR spectroscopy --- electronic absorption and fluorescence studies

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This book is a collection of original research articles in the field of computer-aided drug design. It reports the use of current and validated computational approaches applied to drug discovery as well as the development of new computational tools to identify new and more potent drugs.

Research & information: general --- Chemistry --- 3D-QSAR --- pharmacophore modeling --- ligand-based model --- HDACs --- isoform-selective histone deacetylase inhibitors --- aminophenylbenzamide --- hERG toxicity --- drug discovery --- fingerprints --- machine learning --- deep learning --- gene expression signature --- drug repositioning approaches --- RNA expression regulation --- high-throughput virtual screening --- dual-target lead discovery --- neurodegenerative disorders --- Alzheimer’s disease --- dual mode of action --- multi-modal --- nicotinic acetylcholine receptor --- acetylcholinesterase --- molecular docking --- methotrexate --- drug resistance --- human dihydrofolate reductase --- virtual screening --- molecular dynamics simulation. --- epitope binning --- epitope mapping --- epitope prediction --- antibody:antigen interactions --- protein docking --- glycoprotein D (gD) --- herpes simplex virus fusion proteins --- Src inhibitors --- pharmacophore model --- molecular dynamics simulations --- in silico --- COX-2 inhibitors --- molecular modeling --- sodium–glucose co-transporters 2 --- FimH --- uropathogenic bacteria --- urinary tract infections --- diabetes --- drug-resistance mutations --- HIV-2 protease --- structural characterization --- induced structural deformations --- SARS-CoV-2 --- COVID-19 --- multiprotein inhibiting natural compounds --- MD simulation --- 3CL-Pro --- antivirals --- docking simulations --- drug repurposing --- consensus models --- binding space --- isomeric space --- MRP4 --- SNPs --- variants --- protein threading modeling --- molecular dynamics --- binding site --- hTSPO --- PK11195 --- cholesterol --- homology modeling --- molecular dynamics (MD) simulation --- carbon nanotubes --- Stone–Wales defects --- haeckelite defects --- doxorubicin encapsulation --- drug delivery system --- binding free energies --- noncovalent interactions --- main protease --- mutants --- inhibitors --- PF-00835231 --- Mycobacterium tuberculosis --- tuberculosis --- proteasome --- natural compounds --- multiscale --- multitargeting --- polypharmacology --- computational biology --- drug repositioning --- structural bioinformatics --- proteomic signature --- skin aging --- oxidative stress --- aging progression mechanism --- genome-wide genetic and epigenetic network (GWGEN) --- systems medicine design --- multiple-molecule drug --- immunoproteasome --- non-covalent inhibitors --- MD binding --- metadynamics --- induced-fit docking --- n/a --- Alzheimer's disease --- sodium-glucose co-transporters 2 --- Stone-Wales defects