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This Special Issue addresses relations between tourism activities, smart specialization strategies, and sustainable development at different territorial levels, including the local, regional, national, and international. Framed by appropriate conceptual frameworks to define the contemporary dynamics of innovation in tourism, case studies supported by advanced quantitative methods and developed in rural and urban areas of Asia, Europe, and Africa are presented and discussed. The concept of smart specialization inspires the formulation of regional innovation policies and strategies, emphasizing the importance of endogenous resources and existing territorial capabilities. By exploring the diversity and variety of each economy to develop inter-sectoral relations, this approach aims at promoting the creation of spillover effects of innovation processes supported by adequate key enabling technologies, potentially leading to the sustainable development of places, regions, and countries. As an activity that mobilizes contributions from different economic sectors, tourism may play a central role in such strategies. As described and discussed in this Special Issue, aspects related to the creative sectors of economies, information and communication technologies, traditional products and lifestyles, food production, or diverse cultural values can be mobilized to generate innovative and sustainable solutions for tourism development.

Technology: general issues --- traditional and regional products --- gastronomy tourism --- regional cuisine --- Trabzon --- Podhale region --- sustainable livelihoods --- rural ecological environment --- rural tourism --- smart specialization --- livelihood sustainability index --- rural revitalization strategy --- innovation --- indicators --- governance --- sustainability --- competitiveness --- destination --- life-cycle --- tourism cooperation --- China-ASEAN --- cooperation structure --- driving factors --- regional tourism --- Islamic finance --- halal tourism --- fuzzy numbers --- TOPSIS --- cultural mediating effects --- halal industry --- relatedness --- proximity --- network --- specialization --- panel data --- visual impairment --- smart tourism --- mobile application --- gamification --- experience design --- social sustainability --- disability equality --- accessible tourism for all --- smart tourism technology experience --- tourist satisfaction --- happiness --- revisit intention --- nature interpretation --- visitor codes --- orientation signage --- tour guiding --- visitor management --- Maasai Mara --- sustainable tourism development --- tourism policy --- sustainability indicators --- cluster analysis --- factor analysis --- Mediterranean --- DPSIR