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Successful chromosome replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Inspired by recent exciting breakthroughs in protein structure determination and written by leading experts in the field, The Eukaryotic Replisome: a guide to protein structure and function takes the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosomal DNA replication, from replication origin recognition and the assembly of the pre-replicative complexes in G1 through to the final processing of Okazaki fragments at the end of S-phase. This extensively illustrated book is an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

Cell cycle. --- Chromosome replication. --- Eukaryotic cells. --- Molecular biology. --- Oncology. --- Chromosome replication --- Biochemical Processes --- Macromolecular Substances --- Genetic Processes --- Biochemical Phenomena --- Chemicals and Drugs --- Genetic Phenomena --- Chemical Processes --- Phenomena and Processes --- Chemical Phenomena --- Multiprotein Complexes --- DNA Replication --- Biology --- Health & Biological Sciences --- Cytology --- DNA --- RNA-protein interactions. --- Synthesis. --- Interactions, RNA-protein --- Protein-RNA interactions --- RNA-protein binding --- Deoxyribonucleic acid synthesis --- Medicine. --- Cancer research. --- Biochemistry. --- Nucleic acids. --- Proteins. --- Biomedicine. --- Biomedicine general. --- Biochemistry, general. --- Protein Science. --- Protein Structure. --- Nucleic Acid Chemistry. --- Cancer Research. --- Protein binding --- Tumors --- Polynucleotides --- Biomolecules --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Health Workforce --- Proteins . --- Biomedicine, general. --- Cancer research --- Proteids --- Polypeptides --- Proteomics --- Medicine --- Biomaterials. --- Cancer. --- Biomedical Research. --- Protein Biochemistry. --- Nucleic Acid. --- Cancer Biology. --- Research. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Biological research --- Biomedical research

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This book aims to bring to the forefront a field that has been developing since the late 1990s called the STAR pathway for Signal Transduction and Activation of RNA. It is a signaling pathway that targets RNA directly; in contrast to the canonical signal - kinase cascade - transcription factor - DNA - RNA. It is proposed to allow quick responses to environment changes such as those necessary in many biological phenomenon such as the nervous system and during development.

Cellular signal transduction. --- RNA --Metabolism --Regulation. --- RNA-protein interactions. --- RNA-protein interactions --- RNA --- Cellular signal transduction --- Embryonic and Fetal Development --- Biochemical Processes --- Biological Science Disciplines --- Carrier Proteins --- Nucleoproteins --- Metabolic Phenomena --- Gene Expression Regulation --- Cell Physiological Processes --- Reproduction --- Biochemical Phenomena --- Morphogenesis --- Chemical Processes --- Proteins --- Genetic Processes --- Natural Science Disciplines --- Phenomena and Processes --- Cell Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Genetic Phenomena --- Chemical Phenomena --- Reproductive Physiological Processes --- Disciplines and Occupations --- Growth and Development --- Chemicals and Drugs --- Reproductive Physiological Phenomena --- Physiological Processes --- Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- RNA Processing, Post-Transcriptional --- Transcriptional Activation --- Embryonic Development --- Metabolism --- Signal Transduction --- Physiology --- RNA-Binding Proteins --- Human Anatomy & Physiology --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Regulation --- Regulation. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Ribonucleic acid --- Ribose nucleic acid --- Interactions, RNA-protein --- Protein-RNA interactions --- RNA-protein binding --- Medicine. --- Neurosciences. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Nucleic acids --- Ribose --- Protein binding --- Toxicology. --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology