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Giant cell arteritis (GCA) is a systemic vasculitis that affects medium- to large-size arteries in which an inflammatory reaction destroys the media of the artery wall with the fragmentation of the elastic lamina, which can result in acute vision loss if not treated in a timely manner. The other common visual symptoms may include diplopia due to cranial nerve palsies and transient visual loss. This book provides a comprehensive overview of GCA, with chapters on epidemiology, cellular and molecular characteristics of the disease, extra-cranial involvement of GCA, medical imaging, and much more.
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Protective immune defences are dependent upon critical roles played by dendritic cells (DCs), rendering them important targets for both vaccine delivery and virus infection. Studies in these areas led to successful development of targeted vaccine delivery, including synthetic virus-like particle (SVLP) and nanoparticulate RNA vaccines. A major consideration is DC endocytosis, whereby the different endocytic routes influencing the outcome. Rapid clathrin-mediated endocytosis likely favours degradative pathways. Slower processes such as macropinocytosis, caveolar endocytosis and retrograde transport to endoplasmic reticulum relate more to the processing rates leading to antigen presentation by DCs. These pathways are also influential in promoting the initiation of virus replication following infection. DC endocytosis of RNA viruses and RNA vaccines must lead to cytosolic translocation of the RNA for translation, relating to the process of antigen cross-presentation. One can learn from observations on both virus infections and cross-presentation for delivering RNA vaccines. Accordingly, recent advances in nanoparticulate delivery have been applied with self-amplifying replicon RNA (RepRNA), providing efficient delivery to DCs and promoting replicon-encoded antigen translation. Through realising the important relationships between DC endocytic pathways and induction of immune responses, delivery of SVLP and RepRNA vaccines to DCs offers high value for the development of future synthetic vaccine platforms.
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Dieses farbige, gut zu lesende Lehrbuch führt in die Grundlagen der Immunologie ein, beschäftigt sich aber auch mit aktuellen Themen wie AIDS, Allergie, Autoimmunität und Tumorentstehung. Es gelingt den Autoren die schwierigen Sachverhalte allgemeinverständlich auf einem hochaktuellen Niveau zu vermitteln. Meinungen von Experten aus Deutschland, die in separaten Boxen dargestellt werden, vertiefen das Wissen zu speziellen Themen. Die Erörterung auch von außergewöhnlichen Themen, wie der Immunologie des Alters, der mütterlichen Toleranz gegenüber dem ungeborenen Kind, dem Einfluss der Ernährung und der Psyche auf das Immunsystem, macht das Buch zu einer Gesamtschau der Immunologie, die zum intensiven Studium und auch zum Nachschlagen anregt. Mit der zusammenfassenden Darstellung der angeborenen und erworbenen Immundefekte sowie der Kurzdarstellung von immunologischen Testverfahren und Therapien geht das Buch weit über die theoretischen Grundlagen des Immunsystems hinaus. Es gibt einen Einblick, wie angreifbar der Mensch ohne funktionierendes Immunsystem ist und welche Möglichkeiten die moderne Immunologie für die Diagnostik und Therapie in der Medizin zur Verfügung stellt. Somit ist das Buch nicht nur für den Einsteiger hervorragend geeignet, es bietet auch Fachleuten der Medizin, Biologie, Pharmazie und Biochemie Inhalte, die anderswo so kompakt nur schwer zu finden sind.
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Immunology. --- Immunology. Immunopathology --- Immunology --- Immunologie
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Immunocytochemistry is classically defined as a procedure to detect antigens in cellular contexts using antibodies. However, over the years many aspects of this procedure have evolved within a plethora of experimental setups. There are different ways to prepare a given specimen, different kinds of antibodies to apply, different techniques for imaging, and different methods of analyzing the data. In this book, various ways of performing each individual step of immunocytochemistry in different cellular contexts are exemplified and discussed. Applications of Immunocytochemistry offers technical and background information on different steps of immunocytochemistry and presents the application of this technique and its adaptations in cell lines, neural tissue, pancreatic tissue, sputum cells, sperm cells, preimplantation embryo, arabidopsis, fish gonads, and Leishmania.
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Immunology. --- Allergy and Immunology --- Immunologie. --- Immunology.
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Fishes --- Shellfish --- Crustacea --- Mollusca --- Immunology --- immunology --- Immunology.
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