Listing 1 - 10 of 10 |
Sort by
|
Choose an application
Hypercholestérolémie. --- Hypercholesterolemia --- Hypercholestérolémie.
Choose an application
Using natural products and developing pharmaceutical drugs are emerging topics to reduce blood cholesterol levels for preventing heart disease and stroke. Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different diseases such as homozygous familial hypercholesterolemia, atherosclerosis, cardiovascular disease, and cancer. The relationship between ethnicity and cholesterol-lowering drug responses is also reviewed. Each chapter is a building block for the book, but each individual chapter is also a complete subject package for the readers. Researchers from basic and clinic science interested in lipid and cholesterol metabolism, regulation, and lowering will find this book very useful. Features: - Up-to-date information of the molecular mechanisms of cholesterol lowering, the drugs from natural and pharmaceutical products, and their associated therapeutic strategies in human diseases. - Discussion of the pathogenesis of several human diseases, which are associated with high cholesterol levels and evaluation of the results of different cholesterol-lowering drug treatment in these diseases. - Discussion of the combinations of cancer chemotherapy and cholesterol lowering in potential cancer treatment and cancer prevention by cholesterol-lowering drugs. - Critical analysis of the effect of ethnicity on responses to cholesterol-lowering drug therapy leading to rational dose adjustment of cholesterol-lowering drugs for different people use.
Hypercholesteremia. --- Cholesteremia --- Cholesterolemia --- Hypercholesterolemia --- Hyperlipidemia --- Blood cholesterol --- Medicine --- Cardiology and Cardiovascular Medicine --- Cardiac Electrophysiology --- Health Sciences
Choose an application
Cardiovascular diseases are the first cause of death worldwide, in which genetic and environmental factors seem to play a determinant role. In fact, several lifestyle (i.e., dietary, physical inactivity) factors and nutritional-related diseases (i.e., obesity, type 2 diabetes) are strongly associated with cardiovascular diseases. Moreover, genome-wide association studies have also identified numerous genomic loci that determine susceptibility to cardiovascular events. Therefore, nutrition and genetics seem to interact in predisposing an individual to cardiovascular diseases. This book provides a presentation of recent advances in knowledge on nutrition, genetics, and cardiovascular disease coming from diverse scientific disciplines.
Medicine --- renin-angiotensin-aldosterone system --- tissue --- expression --- physiology --- dietary intake --- nutrition --- cardiovascular disease --- obesity --- hookah --- overweight --- shisha --- abdominal obesity --- weight management --- treatment --- adolescents --- arterial stiffness --- birth weight --- body-size trajectories --- cardio-metabolic health --- children --- growth --- intima-media thickness --- blood pressure --- acute rheumatic fever --- rheumatic heart diseases --- MT-CYB --- mutation --- Senegal --- hypercholesterolemia --- cluster of differentiation 14 --- rs2569190A> --- G --- single nucleotide polymorphisms --- association analysis --- n/a
Choose an application
This special issue of JCM ‘The Prevention and Treatment of Atherosclerosis’ will walk the Readers across novel diagnostic achievements in atherosclerosis and contemporary actions towards optimizing therapy.Everything begins with diagnosis. Accurate diagnostic tools and tests are of utmost importance. Contemporary research on microparticles, non-coding RNAs, proteomic characterization, …, offers detailed molecular characteristics of athero-thrombosis.Prevention is equally important as treatment. The impact of eating habits in prophylaxis of many pathologies, including cardiovascular disease has been documented.Then new pharmacological agents. Managing hypercholesterolemia with PCSK9 inhibitors, shown great potential in efficient lipid lowering to achieve LDL-C treatment goals, as well as reduction in cardiovascular mortality and morbidity.However, therapeutic goals accomplishment requires supervision. Arising number of data support that cardiovascular risk prediction can be improved with imaging modalities displaying atheroma: carotid plaque ultrasonography, coronary calcium score, intravascular ultrasonography, and optical coherent tomography or many others.As atherosclerosis is a progressive disease, it comes the time for more radical management, including endovascular and surgical intervention. There is field for new stent and equipment technologies, new surgical and endovascular techniques, supervision of endovascular procedures with IVUS, OCT, functional flow assessment or cell therapy.From diagnosis to risk stratification, elaborated prevention models, finally to modern and optimized therapeutic intervention.
Research & information: general --- familial hypercholesterolemia --- genetic screening --- atherosclerosis prevention --- early detection --- atherosclerosis --- cigarette smoking --- miR-27b --- peripheral artery disease --- subclinical atherosclerosis --- SCORE --- Framingham --- QRISK --- PROCAM --- cardiovascular risk --- pulse wave velocity --- intima media thickness --- malondialdehyde low-density lipoprotein --- high-risk plaque --- coronary computed tomography angiography --- statin --- cardiovascular risk factors --- heart failure --- major cardiac and cerebral ischemic events --- degenerative aortic stenosis --- risk stratification --- vascular resistance --- cardiovascular disease --- acute myocardial infarction --- intravascular imaging --- statins --- control-theoretic model --- logistic growth --- coronary artery disease --- fibrin clot --- fibrinolysis --- thromboembolism --- carotid intima-media complex --- carotid plaque --- major adverse cardiac and cerebral events --- prevention --- scores --- vitamin D --- myocardial infarction --- males --- Coronary Artery Surgery Study Score --- n/a
Choose an application
The field of design and health, formerly known as the domain of healthcare design professionals, has now reached a turning point with the proliferation of a plethora of non-invasive wearable technologies, to provide the objective and near-real-time measurement of the impact of many features of the built environment on aspects of health, wellbeing and performance. In turn, new materials and the Internet of Things are allowing the development of smart buildings, which can interact with occupants to optimize their health, wellbeing, performance and overall experience. Companies that have previously focused on positioning themselves as “green” are now turning to positioning themselves in the marketplace as both green and healthy. This Special Issue will include articles that address new cutting edge technologies and materials at the interface between design and health, and review some of the latest findings related to studies which use these technologies. This SI will also suggest exciting future directions for the field. It will include articles which focus on the objective data gathered to document the effects of the built environment on health. Importantly, it will focus on the use of innovative methods of measurement, such as state-of-the-art wearable and environmental sensors, quantifying some aspects of health, such as stress and relaxation responses, activity, posture, sleep quality, cognitive performance and wellbeing outcomes. It will also examine the impacts of different elements of the built environment on these health and wellbeing outcomes. The published articles will focus on the design interventions informed by these measurements, along with innovative integrated building materials that can shape the design of built environments for better health, productivity, and performance. It will also address the return on investment (ROI) of such design interventions. This Special Issue will provide both the foundational knowledge and fundamentals for characterizing human health and wellbeing in the built environment, as well as the emerging trends and design methods for innovations in this field.
Research & information: general --- lifestyle --- mood states --- perceived restorativeness scale --- positive and negative affect schedule --- quality of life --- resilience --- restorative outcome scale --- Shinrin-yoku --- stress coping --- subjective vitality scale --- open spaces 2 --- CKD 3 --- renal function --- exercise --- obesity --- urban environment --- walkability --- active transportation --- college students --- supportive soundscape --- sonic environment --- nursing homes --- ageing --- dementia --- green spaces --- cardiovascular risk factors --- gender --- hypercholesterolemia --- hypertension --- diabetes --- bamboo forest therapy --- psychological responses --- physiological responses --- immune system --- violent crime --- urban parks --- greenspace --- green space --- scoping review --- systematic review --- literature review --- urban --- landscape --- brain --- visual --- green --- contemplative --- mental health --- well-being --- FAA --- EEG --- UGS --- depression --- human health --- built environment --- urban open space --- forest healing --- wellbeing --- psychology --- physiology
Choose an application
Contemporary healthcare trends indicate that many chronic and communicable diseases are related to lifestyle, stress, personal choices and systemic factors. In response to the shortfalls of modern medicine regarding the prevention of these diseases and the promotion of whole-person health, providers and consumers worldwide are exploring integrative, natural and complementary approaches to prevention, treatment and health promotion. These trends harbor the future of medicine. The issues of clinician burnout, high rates of adverse effects, high cost, and lack of rigorous methods to promote individual and collective immunity are addressed by leading physicians and scientists from around the world. The original research and reviews in this volume investigate efficacy, molecular mechanisms and hypotheses that suggest that traditional systems of medicine and health, e.g., Ayurveda, yoga, traditional Chinese medicine, and mind–body–lifestyle medicine, may offer preventive and cost-effective solutions to contemporary health care challenges. Integrating innovative health approaches with conventional medicine offers a whole system of medicine that encompasses the individual, family, community and environment—from single person to planetary health.
Medicine --- asthma --- diagnosis --- treatment strategies --- oxidative stress --- antioxidants --- microbiome --- Ayurveda --- gut bacteria --- diet --- lifestyle --- disease --- prevention --- integrative medicine --- Ayurgenomics --- genomics --- P4 medicine --- personalized medicine --- epigenetics --- genotype --- phenotype --- Prakriti --- doshas --- meditation --- focused attention --- open monitoring --- Transcendental Meditation --- antiviral --- medicinal plants --- pandemic --- SARS-CoV-2 --- zoonotic virus --- Artemisia --- Artemisinin --- ARTs --- phytochemicals --- chronic stress --- transcendental meditation --- gene expression --- energy metabolism --- biological aging --- epigenetic effects --- allostatic load --- complementary medicine --- plastic surgery --- anthroposophic medicine --- pandemic and women --- women and heart disease --- psychological effects of pandemic --- cardiac prevention --- risk of heart disease in women --- hypercholesterolemia --- ayurveda --- ayurvedic herbs --- systematic review --- meta-analysis --- integrative health --- whole-person health --- systems research --- reductionism --- complementary and alternative medicine --- healing --- healthcare transformation --- overview --- stroke --- vegetarian --- vegan --- dosha --- prakriti --- integrative nutrition --- n/a
Choose an application
Nutritional epidemiology examines dietary or nutritional factors in relation to the occurrence of disease in various populations. It is a fact that substantial progress has been made in recent years in nutritional epidemiology. Compared to the practice during the 1990s, and with the improvements in data analytics, several new approaches are gaining ground. Results from a variety of large-scale studies in the field of nutrition epidemiology have substantially contributed toward the evidence used in guiding dietary recommendations for the prevention of cardiovascular diseases, metabolic disorders, some types of cancer, and other morbidities. In this Special Issue, we would like to bring readers closer to the state-of-the-art in the field by gathering papers covering different aspects of nutrition epidemiology from population-based observational studies. Topics of the submitted articles may, but not necessarily, include eating habits of various populations, especially of those not well-studied, such as in Africa, Oceania, South Americas, immigrants, minorities, as well as a variety of associations between nutrients/foods/food patterns and chronic diseases, like cardiovascular, diabetes, obesity, cancer, etc., and gene–nutrient and epigenome–nutrient interactions related to human health at all ages.
Research & information: general --- Biology, life sciences --- Food & society --- healthy diet indexes --- food intake --- apulia --- mind index --- dash index --- med-diet score --- dietary patterns --- eating restrictions --- food involvement --- adults --- obesity --- nutrition assessment --- diet survey --- dietary pattern analysis --- nutrient inadequacy --- overweight and obesity --- nutritional epidemiology --- nutrition transition --- pastoral nomadism --- Mongolia --- central Asia --- breakfast consumption --- breakfast composition --- children --- dietary intake --- dietary quality --- diet patterns --- cardiometabolic outcomes --- adiposity --- short-chain fatty acids --- BMI --- waist-to-height ratio --- fiber --- gut metagenome --- diet --- plant sterols --- stanols --- omega-3 fatty acids --- familial hypercholesterolemia --- nutritional status --- population survey --- oral frailty --- health behavior --- eating competence --- health outcomes --- validation --- questionnaire --- food consumption --- salty snack products --- students --- consumption --- salt intake --- health policies --- nutrition policies --- Europe --- primary care --- breakfast intake --- lifestyle behaviors --- sociodemographic factors
Choose an application
The first national conference with international participation, “Fundamental aspects of atherosclerosis: scientific research for improving the technologies of personalized medicine”, was held in Novosibirsk on 15 October, 2021. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of atherosclerosis among various relevant specialists. The conference was intended for practicing cardiologists, primary care physicians, medical geneticists, and physician–scientists. The conference included plenary sessions, specialty sessions, satellite symposia, an open competition for young scientists.
Medicine --- Cardiovascular medicine --- metalloproteinases --- calcification --- atherosclerosis --- multiplex assay --- coronary heart disease --- aspirin --- resistance --- non-sensitivity --- antiplatelet --- light transmission aggregometry --- Plateletworks® --- familial hypercholesterolemia --- targeted sequencing technologies --- multiplex ligation-dependent probe amplification --- LDLR --- APOB --- ABCG5 --- APOC3 --- LPL --- SREBF1 --- rare variants --- coronary atherosclerosis --- ischemic heart disease --- saturated fatty acids --- monounsaturated fatty acids --- polyunsaturated fatty acids --- oxidative stress --- superoxide dismutase --- catalase --- glutathione peroxidase --- cumulative LDL-C level --- prognosis --- DNA methylation --- epigenetic age --- myocardial infarction --- acute coronary syndrome --- population --- nested case-control --- HAPIEE project --- HAPIEE study --- atrial fibrillation --- arterial hypertension --- obesity --- diabetes mellitus --- aging --- determinants --- prevalence --- Russian population cohort --- Cox regression analysis --- adiponectin --- leptin --- interleukin-6 --- epicardial adipose tissue --- perivascular adipose tissue --- circulating biochemical markers --- coronary atherosclerosis presence and severity --- integrated biomarker (i-BIO) --- validation --- visual markers --- lipoprotein(a) --- immune cells blood count --- n/a
Choose an application
In this Special Issue, we have published papers on the health-promoting effects of nutraceuticals from different sources, and their effects in different pathologies. Extracts from plants have been analyzed, for example, extracts from olive leaves, Mikania micrantha, the devil’s claw, raspberries and others, alongside marine phytoplankton, egg-yolk and marketed dietary supplements. The effects of these extracts and dietary supplements have been studied in diseases associated with obesity, and in diseases where inflammation pathways are involved. The effectiveness of resveratrol and curcumin to support the anticancer activity of cisplatin has also been reported, as well as the ability of devil’s claw root extract to stimulate the CB2 receptors in synoviocytes in osteoarthritis patients. The anti-oxidant effect of marine phytoplankton has been studied on muscle damage, both in humans and in an animal model, and the effects of the metabolite of antocianin were analyzed in a mouse model of amyotrophic lateral sclerosis. Finally, reviews on the use of lactoferrin, ω3 and ω6 and abscisic acid have been reported, in addition to the crosstalk between prostate cancer and microbiota inflammation. Although it is not yet possible to draw definitive conclusions on the use of nutraceuticals, several mechanisms of action for many of them have been further clarified.
Humanities --- Social interaction --- fertility --- ingredients --- male reproduction --- semen parameters --- supplements --- allithiamine --- garlic --- hyperglycaemia --- advanced glycation end-products --- cytokines --- abscisic acid --- prediabetes --- type 2 diabetes mellitus --- metabolic syndrome --- insulin resistance --- adipocyte browning --- AMP-activated protein kinase --- food supplement --- frambinone --- meal frequency --- open-field test --- elevated plus maze --- sensory motor gating --- pre-pulse inhibition --- c-Fos --- amyotrophic lateral sclerosis --- anti-inflammatory --- antioxidant --- phenolic acid --- neuroprotective --- neurodegeneration --- obesity --- overweight --- beta-glucans --- chitosan --- follow up study --- weight loss programs --- weight gain --- weight loss --- body weight changes --- phytoplankton --- antioxidants --- muscle damage --- muscle recovery --- muscle soreness --- Viburnum opulus --- phenolic compounds --- adipogenesis --- PPARγ --- lipase inhibition --- green tea --- epigallocatechin --- lipid profile --- high-fat diet --- fast food --- osteoarthritis --- nutraceuticals --- polyphenols --- volatile compounds --- β-caryophyllene --- eugenol --- FAAH --- cannabinoid receptors --- phospholipases --- lactoferrin --- bovine milk --- nutraceutical --- human health --- resveratrol --- curcumin --- cisplatin --- head and neck cancer --- cell cycle --- apoptosis --- prostate cancer --- microbiota --- nutraceutical compounds --- fecundation --- inflammation --- cytokine --- growth factors --- metabolomics --- lipidomics --- ω-3PUFAs --- ω-6PUFAs --- endocannabinoids --- CRC --- fatty acids --- Gymnema inodorum --- gymnemic acid --- Mikania micrantha --- anti-hypercholesterolemia --- steatosis --- olive leaf --- macrophages
Choose an application
Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.
Atherosclerosis. --- Anticholesteremic agents. --- Statins (Cardiovascular agents) --- Hydroxymethylglutaryl coenzyme A reductases --- Statin drugs --- Anticholesterol drugs --- Antihypercholestermic agents --- Cholesterol inhibitors --- Cholesterol-lowering drugs --- Hypocholesteremic agents --- Inhibitors --- Anticholesteremic agents --- Enzyme inhibitors --- Antilipemic agents --- Arteriosclerosis --- Atherosclerosis --- Therapeutics --- Hypolipidemic Agents --- Hyperlipidemias --- Sterols --- Cholestenes --- Lipid Regulating Agents --- Membrane Lipids --- Dyslipidemias --- Cholestanes --- Antimetabolites --- Lipids --- Arterial Occlusive Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Steroids --- Chemicals and Drugs --- Molecular Mechanisms of Pharmacological Action --- Vascular Diseases --- Lipid Metabolism Disorders --- Therapeutic Uses --- Metabolic Diseases --- Pharmacologic Actions --- Polycyclic Compounds --- Cardiovascular Diseases --- Chemical Actions and Uses --- Nutritional and Metabolic Diseases --- Diseases --- Cholesterol --- Drug Therapy --- Hypercholesterolemia --- Anticholesteremic Agents --- Atherogenesis --- Atheroscleroses --- Chylomicron Remnants --- Plaque, Atherosclerotic --- Anticholesteremic Drugs --- Anticholesteremics --- Inhibitors, Cholesterol --- Cholesterol Inhibitors --- Hypocholesteremic Agents --- Agents, Anticholesteremic --- Agents, Hypocholesteremic --- Drugs, Anticholesteremic --- Elevated Cholesterol --- High Cholesterol Levels --- Hypercholesteremia --- Cholesterol Level, High --- Cholesterol Levels, High --- Cholesterol, Elevated --- Cholesterols, Elevated --- Elevated Cholesterols --- High Cholesterol Level --- Hypercholesteremias --- Hypercholesterolemias --- Level, High Cholesterol --- Levels, High Cholesterol --- Cholesterol, Dietary --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Epicholesterol --- Nutritional Physiological Phenomena --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Compounds, Polycyclic --- Hydrocarbons, Cyclic --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Lipid Metabolism Disorder --- Metabolism Disorder, Lipid --- Metabolism Disorders, Lipid --- Disease, Vascular --- Diseases, Vascular --- Vascular Disease --- Pharmacological Mechanisms of Action --- Catatoxic Steroids --- Steroid --- Steroids, Catatoxic --- Arterial Obstructive Diseases --- Arterial Obstructive Disease --- Arterial Occlusive Disease --- Disease, Arterial Obstructive --- Disease, Arterial Occlusive --- Diseases, Arterial Obstructive --- Diseases, Arterial Occlusive --- Obstructive Disease, Arterial --- Obstructive Diseases, Arterial --- Occlusive Disease, Arterial --- Occlusive Diseases, Arterial --- Lipid --- Antimetabolite --- Dyslipidemia --- Dyslipoproteinemias --- Dyslipoproteinemia --- Cell Membrane Lipid --- Cell Membrane Lipids --- Membrane Lipid --- Lipid, Cell Membrane --- Lipid, Membrane --- Lipids, Cell Membrane --- Lipids, Membrane --- Membrane Lipid, Cell --- Membrane Lipids, Cell --- Cell Membrane --- Membranes --- Lipid Regulating Drugs --- Agents, Lipid Regulating --- Drugs, Lipid Regulating --- Regulating Agents, Lipid --- Regulating Drugs, Lipid --- Sterol --- Antihyperlipemics --- Antihyperlipidemics --- Antilipemic Drugs --- Antilipemics --- Hypolipidemic Drugs --- Antihyperlipidemic --- Antilipemic --- Antilipemic Agents --- Antilipemic Drug --- Hypolipidemic Agent --- Hypolipidemic Drug --- Agent, Hypolipidemic --- Agents, Antilipemic --- Agents, Hypolipidemic --- Drug, Antilipemic --- Drug, Hypolipidemic --- Drugs, Antilipemic --- Drugs, Hypolipidemic --- Arterioscleroses --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Hyperlipidemia --- Lipemia --- Lipidemia --- Hyperlipemia --- Hyperlipemias --- Lipemias --- Lipidemias --- antagonists & inhibitors --- drug therapy --- therapeutic use --- therapy --- Statins (Cardiovascular agents). --- therapeutic use. --- drug therapy. --- etiology. --- adverse effects. --- complications.
Listing 1 - 10 of 10 |
Sort by
|