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Amylases --- Enzymes --- Amylases. --- Enzymes. --- Biocatalysts --- Ferments --- Soluble ferments --- Diastase --- Ptyalin --- Catalysts --- Proteins --- Enzymology --- Digestive enzymes --- Glycosidases --- Amylolysis --- Animal Biochemistry

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This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.

Chemistry. --- Bioorganic chemistry. --- Carbohydrates. --- Medicinal chemistry. --- Biomaterials. --- Medicinal Chemistry. --- Carbohydrate Chemistry. --- Bioorganic Chemistry. --- Clinical chemistry. --- Glycosidases. --- Chemistry, Clinical --- Diagnostic biochemistry --- Diagnostic chemistry --- Medical chemistry --- Biochemistry --- Diagnosis, Laboratory --- Glycoside hydrolases --- Hydrolases --- Biochemistry. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Bio-organic chemistry --- Biological organic chemistry --- Chemistry, Organic --- Carbs (Carbohydrates) --- Biomolecules --- Organic compounds --- Glycomics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Bioartificial materials --- Hemocompatible materials --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medicinal chemistry --- Pharmacochemistry --- Biomaterials (Biomedical materials)

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Applied biocatalysis and biotransformation, that is, the use of enzymes and whole-cell systems in manufacturing processes for synthetic purposes, has been experiencing a clear boom in recent years, which has led to the start of the so-called “fourth wave”. In fact, the latest advances in bioinformatics, system biology, process intensification, and, in particular, enzyme-directed evolution (encouraged by the 2018 Nobel Prize awarded to F. Arnold), are widening the range of the efficacy of biocatalysts and accelerating the rate at which new enzymes are becoming available, even for activities not previously known. European scientists have been very actively involved in different aspects of this field. Nine contributions dealing with different aspects of applied biocatalysis developed by European researchers are gathered in this Special Issue

Research & information: general --- biocatalysis --- glycosidases --- isomerases --- Pichia pastoris --- sweeteners --- rare sugars --- cheese whey --- sustainable chemistry --- penicillin acylase --- aculeacin acylase --- N-acyl-homoserine lactone acylases --- quorum quenching --- biofouling --- estolides --- castor oil --- lipase --- candida antarctica lipase A --- Arabidopsis thaliana --- hydroxynitrile lyase --- oxynitrilase --- His-tag --- immobilization --- batch --- continuous flow --- Geobacillus thermocatenolatus --- lipases --- ethanolysis --- ionic liquids --- kinetic resolution --- mandelic acid --- Aspergillus --- fermentation --- filamentous fungi --- genetic engineering --- heterologous expression --- recombinant protein --- secretion --- transcriptional regulation --- n/a --- Halohydrin dehalogenases --- conformational dynamics --- active site tunnels --- molecular dynamics simulations --- omega-3 ethyl esters --- monkfish liver oil --- COSMO-RS --- fungal resting cells --- selectivity --- ketone body ester --- asymmetric synthesis --- configuration inversion

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Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.

Tropical medicine. --- Influenza viruses --- Drug Discovery --- Respiratory Tract Infections --- Orthomyxoviridae Infections --- RNA Viruses --- Therapeutics --- Glycoside Hydrolases --- Investigative Techniques --- Chemistry, Pharmaceutical --- Vertebrate Viruses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Hydrolases --- Respiratory Tract Diseases --- Viruses --- RNA Virus Infections --- Diseases --- Chemistry --- Organisms --- Pharmacology --- Virus Diseases --- Enzymes --- Enzymes and Coenzymes --- Natural Science Disciplines --- Biological Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Drug Therapy --- Orthomyxoviridae --- Drug Design --- Influenza, Human --- Neuraminidase --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Microbiology & Immunology --- Influenza viruses. --- Neuraminidase. --- Sialidase --- Medicine. --- Immunology. --- Pharmacology. --- Virology. --- Infectious diseases. --- Biomedicine. --- Pharmacology/Toxicology. --- Infectious Diseases. --- Glycosidases --- Orthomyxoviruses --- Toxicology. --- Emerging infectious diseases. --- Medical virology. --- Immunobiology --- Life sciences --- Serology --- Medical microbiology --- Virology --- Virus diseases --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Microbiology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Cellulase is a key enzyme of industrial interest and plays a crucial role in the hydrolysis of cellulose, a prime component of plant cell walls. Cellulase covers a broad area in the global market of industrially important enzymes and it is considered as the third largest industrial enzyme globally. Additionally, cellulase contributes about 20% of the total enzyme market globally because of its massive demand in various industries such as in biofuel production, pulp, paper, textile, food, and beverages, as well as in detergent industries. Among these, the demand of cellulase may become frequently selected in the commercial production of biofuels in the future and thus will further increase demand of cellulase in the biofuel industry. Because biofuel production is still not realized in a cost-effective, practical implementation due to its high cost (the higher cost of biofuels is due to higher production costs of enzymes), there is a need to introduce these types of approaches, which will help to lower the cost of enzyme production for developing overall economic biofuel production.

Cellulase. --- Cellulase --- Biotechnology. --- Endo-1,4-beta-glucanase --- Glucanase, Endo-1,4-beta --- Glycosidases --- Entomology. --- Plant breeding. --- Biochemistry. --- Plant genetics. --- Biomedical engineering. --- Mycology. --- Plant Breeding/Biotechnology. --- Plant Biochemistry. --- Plant Genetics and Genomics. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Plants --- Genetics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Crops --- Agriculture --- Breeding --- Insects --- Zoology --- Composition --- Plant biochemistry. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Fungi --- Microbiology --- Fungal biology --- Fungology --- Fungus biology --- Fungi. --- Microbiology. --- Plant biotechnology. --- Botanical chemistry. --- Plant Biotechnology. --- Plant Genetics. --- Chemical engineering --- Genetic engineering --- Crop biotechnology --- Agricultural biotechnology --- Microbial biology --- Microorganisms --- Fungal kingdom --- Fungus kingdom --- Funguses --- Mycobiota --- Mycota --- Cryptogams --- Mycology --- Biotechnology