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In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibition strategies are one of the fastest expanding areas in the field of of drugs that show considerable promise. This Special Issue will focus on the recent advances in the discovery and development of protease inhibitors, covering the synthesis of protease inhibitors, the design of new chemical entities acting as inhibitors of special/particular types of proteases, and their mode of actions (Frolova et al. 2020; Slapak et al. 2020; Künnapuu et al. 2021). In addition, the new applications of these interesting compounds/biomolecules and their limitations have been discussed and described (Wang et al. 2020; Bartošová-Sojková et al. 2021).

Research & information: general --- MMP --- MMP2 --- MMP9 --- MMP7 --- MMP14 --- matrix metalloproteases --- PDAC --- pancreatic cancer --- Bowman–Birk inhibitor --- ranacyclin --- trypsin inhibitor --- structure–activity relationship --- synergistic effect --- Gentamicin --- matrix metalloproteinase --- extracellular matrix --- nuclei --- cancer --- apoptosis --- immune response --- cysteine protease inhibitor --- stefin --- signal peptide --- parasite --- phylogenetic analysis --- diversification --- protein structure --- vascular endothelial growth factors (VEGFs) --- VEGF-A --- PlGF --- VEGF-B --- VEGF-C --- VEGF-D --- angiogenesis --- lymphangiogenesis --- CCBE1 --- proteases --- ADAMTS3 --- plasmin --- cathepsin D --- KLK3 --- prostate-specific antigen (PSA) --- thrombin --- wound healing --- metastasis --- proteolytic activation --- vascular biology --- lymphedema

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Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit the specific needs of different researchers and experimental scenarios, resulting in a myriad of technical variants of basic assay approaches.  "The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications" is an up-to-date comprehensive textbook on angiogenesis and lymphangiogenesis techniques and applications. This volume is designed to embody the collective works of experts in the clinical as well as the basic research arenas who have significantly contributed to the development and application of techniques in all areas of angiogenesis and lymphangiogenesis. Each chapter introduces and discusses one or a group of closely related techniques and convey step-by-step protocol information and detailed technical guidance to the reader. Emphasis has been placed on explanatory illustrations, critical technical steps as well as divulging information on the benefits and caveats of specific practices related to the methods discussed. This manual is intended to serve as a written guide for both newcomers and established professionals in the field.

Angiogenesis. --- Heart -- Diseases -- Treatment. --- Medicine. --- Neovascularization --- Publication Formats --- Epithelial Cells --- Animal Diseases --- Organogenesis --- Models, Animal --- Angiogenic Proteins --- Models, Biological --- Cardiovascular Physiological Processes --- Intercellular Signaling Peptides and Proteins --- Embryonic and Fetal Development --- Investigative Techniques --- Diseases --- Publication Characteristics --- Cells --- Models, Theoretical --- Cardiovascular Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anatomy --- Peptides --- Biological Factors --- Circulatory and Respiratory Physiological Phenomena --- Proteins --- Morphogenesis --- Amino Acids, Peptides, and Proteins --- Growth and Development --- Phenomena and Processes --- Chemicals and Drugs --- Physiological Processes --- Physiological Phenomena --- Endothelial Cells --- Vascular Endothelial Growth Factors --- Laboratory Manuals --- Disease Models, Animal --- Lymphangiogenesis --- Neovascularization, Physiologic --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Angiogenesis, Physiological --- Neovascularization, Physiological --- Physiologic Angiogenesis --- Physiologic Neovascularization --- Angiogenesis, Physiologic --- Physiological Angiogenesis --- Physiological Neovascularization --- Lymphangiogeneses --- Lymphatic Vessels --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- VEGFs --- Capillary Endothelial Cells --- Lymphatic Endothelial Cells --- Vascular Endothelial Cells --- Capillary Endothelial Cell --- Cell, Capillary Endothelial --- Cell, Endothelial --- Cell, Lymphatic Endothelial --- Cell, Vascular Endothelial --- Cells, Capillary Endothelial --- Cells, Endothelial --- Cells, Lymphatic Endothelial --- Cells, Vascular Endothelial --- Endothelial Cell --- Endothelial Cell, Capillary --- Endothelial Cell, Lymphatic --- Endothelial Cell, Vascular --- Endothelial Cells, Capillary --- Endothelial Cells, Lymphatic --- Endothelial Cells, Vascular --- Lymphatic Endothelial Cell --- Vascular Endothelial Cell --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Development and Growth --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Circulatory and Respiratory Physiological Phenomenon --- Physiology, Circulatory and Respiratory --- Circulatory and Respiratory Physiology --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biological Agents --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Polypeptides --- Anatomies --- Cardiovascular Physiological Concepts --- Cardiovascular Physiological Phenomenon --- Cardiovascular Physiological Process --- Physiology, Cardiovascular --- Cardiovascular Physiologic Processes --- Cardiovascular Physiology --- Cardiovascular Physiological Concept --- Cardiovascular Physiological Phenomenas --- Concept, Cardiovascular Physiological --- Concepts, Cardiovascular Physiological --- Phenomena, Cardiovascular Physiological --- Phenomenon, Cardiovascular Physiological --- Physiologic Processes, Cardiovascular --- Physiological Concept, Cardiovascular --- Physiological Concepts, Cardiovascular --- Physiological Phenomena, Cardiovascular --- Physiological Phenomenon, Cardiovascular --- Physiological Process, Cardiovascular --- Physiological Processes, Cardiovascular --- Process, Cardiovascular Physiological --- Processes, Cardiovascular Physiologic --- Processes, Cardiovascular Physiological --- Cardiovascular System --- Experimental Model --- Experimental Models --- Mathematical Model --- Model, Experimental --- Models (Theoretical) --- Models, Experimental --- Models, Theoretic --- Theoretical Study --- Mathematical Models --- Model (Theoretical) --- Model, Mathematical --- Model, Theoretical --- Models, Mathematical --- Studies, Theoretical --- Study, Theoretical --- Theoretical Model --- Theoretical Models --- Theoretical Studies --- Cell --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Prenatal Programming --- Embryo and Fetal Development --- Programming, Prenatal --- Growth Factors --- Paracrine Peptide Factors --- Paracrine Protein Factors --- Peptide Factors, Paracrine --- Biological Model --- Biological Models --- Model, Biological --- Models, Biologic --- Biologic Model --- Biologic Models --- Model, Biologic --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Diseases, Animal --- Disease --- Adenomatous Epithelial Cells --- Columnar Glandular Epithelial Cells --- Cuboidal Glandular Epithelial Cells --- Glandular Epithelial Cells --- Squamous Cells --- Squamous Epithelial Cells --- Transitional Epithelial Cells --- Adenomatous Epithelial Cell --- Cell, Adenomatous Epithelial --- Cell, Epithelial --- Cell, Glandular Epithelial --- Cell, Squamous --- Cell, Squamous Epithelial --- Cell, Transitional Epithelial --- Cells, Adenomatous Epithelial --- Cells, Epithelial --- Cells, Glandular Epithelial --- Cells, Squamous --- Cells, Squamous Epithelial --- Cells, Transitional Epithelial --- Epithelial Cell --- Epithelial Cell, Adenomatous --- Epithelial Cell, Glandular --- Epithelial Cell, Squamous --- Epithelial Cell, Transitional --- Epithelial Cells, Adenomatous --- Epithelial Cells, Glandular --- Epithelial Cells, Squamous --- Epithelial Cells, Transitional --- Glandular Epithelial Cell --- Squamous Cell --- Squamous Epithelial Cell --- Transitional Epithelial Cell --- Epithelium --- Angiogenesis --- growth & development --- physiology --- veterinary --- cytology --- Angiogenic Peptides --- Cancer research. --- Angiology. --- Cell culture. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Cell Culture. --- Oncology. --- Angiography. --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Tumors --- Cultures (Biology) --- Cytology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Radiography --- Technique --- Health Workforce --- Neovascularization. --- Biomedicine, general. --- Cancer research