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Infertility, Male. --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Diseases --- Estrès oxidatiu --- Esterilitat masculina

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Infertility, Male. --- Oxidative stress. --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Oxidation-reduction reaction --- Stress (Physiology) --- Diseases --- Estrès oxidatiu --- Esterilitat masculina

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This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content. Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.

Reproductive Medicine. --- Andrology. --- Generative organs, Male --- Human reproduction --- Men --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Endocrine aspects --- Diseases --- Physiology --- Health aspects --- Reproductive medicine. --- Varicocele. --- Infertility, Male. --- Male infertility --- Male sterility --- Sterility, Male --- Infertility --- Spermatic cord --- Varicose veins

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I notevoli recenti progressi conoscitivi nel campo della citogenetica e della genetica molecolare hanno consentito di individuare anomalie cromosomiche e mutazioni geniche responsabili di numerose infertilità maschili, fino a poco tempo fa del tutto ignorate. Il fatto non è senza rilevanza, se vale il principio che il riconoscimento delle cause di una malattia costituisce anche il primo e necessario approccio verso una sua corretta terapia. Con la presente pubblicazione gli Autori hanno voluto offrire agli specialisti che operano nel campo della procreazione assistita un aggiornamento su questa complessa materia, trattando sia le cause genetiche nell’infertilità maschile sia l’infertilità nelle malattie genetiche. Nel CD-Rom che accompagna il volume, centinaia di malattie genetiche, estrapolate da GENUS (clinical database di oltre 6.000 disordini genetici) sono raggruppate in 23 short report, la cui bibliografia prevede un link diretto a OMIM (Online Mendelian Inheritance in Man) e a GENUS per un aggiornamento in tempo reale.

Infertility, Male --- Generative organs, Male --- Genetic aspects. --- Diseases. --- Male infertility --- Male sterility --- Sterility, Male --- Infertility --- Diseases --- Human genetics. --- Reproductive Medicine. --- Urology. --- Endocrinology. --- Gynecology. --- Human Genetics. --- Gynaecology --- Medicine --- Generative organs, Female --- Internal medicine --- Hormones --- Genitourinary organs --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Health aspects --- Reproductive medicine. --- Endocrinology . --- Gynecology .

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This state-of-the-art laboratory manual includes 20 clinical protocols used daily for the investigation of the infertile male, presented with easy to understand, step-by-step methodology. The protocols are arranged from routine to advanced laboratory procedures common to clinical practice, including computer-assisted semen analysis, sperm preparation for IUI by density gradient and swim-up, sperm cryopreservation, and sperm DNA fragmentation test by TUNEL method, among others. The methodology in each protocol follows best practice guidelines made clearer by professionally hand-drawn illustrations covering most of the important steps and equipment. The authors, hailing from the world-renowned Andrology Center at Cleveland Clinic, have over 50 years of combined first-hand experience in managing very busy diagnostic and research facilities in male infertility and andrology. The book will be an indispensable resource for thousands of laboratory technologists, clinicians and reproductive professionals (andrologists, embryologist, etc.) engaged in the diagnosis and management of infertile men around the world.

Medicine. --- Endocrinology. --- Reproductive medicine. --- Andrology. --- Medicine & Public Health. --- Reproductive Medicine. --- Infertility, Male --- Diagnosis --- Research --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Diseases --- Internal medicine --- Hormones --- Human reproduction --- Men --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Endocrine aspects --- Physiology --- Health aspects --- Endocrinology . --- Reproductive health.