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This book focuses on the recent advancements in both fundamental and clinical research, focusing on identifying, developing, and applying new and improved biological markers for specific neurologic disorders in the future. The original research work and review articles published here highlight some unique mechanisms underlying the most prevalent pathophysiological conditions affecting human health. Other areas covered in the book include emerging treatment options and correct diagnoses using different biochemical and imaging techniques.

Medicine --- Alzheimer’s disease --- amyloid beta --- hippocampus --- Kir channels --- K+ channels --- glioblastoma multiforme --- low-grade glioma --- astrocytoma --- recurrence --- multifocal growth --- mRNA expression --- MPS1 --- TTK --- therapy --- EDTA chelation therapy --- neurodegenerative diseases --- metal detoxification --- reactive oxygen species (ROS) --- neuroinflammation --- neurodegeneration --- cognitive dysfunction --- neurofibrillary tangles --- diagnosis methods --- biomarkers --- perinatal stress --- NURR1 --- inflammation --- late-onset diseases --- early life --- artificial neural network --- deep learning --- Parkinson’s disease --- atypical parkinsonian syndrome --- dopamine transporter SPECT --- β-Amyloid --- calpain --- Collapsin Response Mediator Protein-2 --- human-neuroblastoma SH-SY5Y cells --- Somatostatin-14 --- somatostatin receptor --- brain injury --- quinpirole --- dopamine D2 receptors --- glial cell --- autophagy --- mitophagy --- multiple sclerosis --- biomarker --- neurons --- astrocytes --- Alzheimer’s and Parkinson’s diseases --- fluid and imaging biomarkers --- amyloid-β and tau --- miRNA --- extracellular vesicles --- exosomes and ectosomes --- PET --- radiotracers --- radiolabeled molecules --- n/a --- Alzheimer's disease --- Parkinson's disease --- Alzheimer's and Parkinson's diseases

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Radiopharmaceuticals are used in the diagnosis and treatment of various diseases, especially cancer. In general, radiopharmaceuticals are either salts of radionuclides or radionuclides bound to biologically active molecules, drugs, or cells. Tremendous progress has been made in discovering, developing, and commercializing numerous radiopharmaceuticals for the imaging and therapy of cancer. Significant research is ongoing in academia and the pharmaceutical industry to develop more novel radiolabeled compounds as potential radiopharmaceuticals for unmet needs. This Special Issue aims to focus on all aspects of the design, characterization, evaluation, and development of novel radiolabeled compounds for the diagnosis and treatment of cancer and the application of new radiochemistry and methodologies for the development of novel radiolabeled compounds. Outstanding contributions presented in this Special Issue will significantly add to the field of radiopharmaceuticals.

Research & information: general --- Chemistry --- positron emission tomography (PET) --- pyrazoles --- fluorine-18 --- radionuclides --- PET probes --- imaging pharmaceuticals --- hypopharyngeal cancer --- 188Re-liposome --- repeated therapy --- NGS --- microRNA --- aprepitant --- radiopharmaceuticals --- neurokinin 1 receptor antagonist --- radionuclide chelators --- kidney uptake --- cleavable linkers --- neutral endopeptidase (NEP) --- renal brush border enzymes --- prostate-specific membrane antigen (PSMA) --- cancer imaging and therapy --- somatostatin analogs --- radiolabeling --- radionuclide therapy --- imaging --- adrenergic receptor --- positron emission tomography --- radiotracer --- cholecystokinin-2 receptor --- minigastrin --- molecular imaging --- targeted radiotherapy --- lutetium-177 --- EpCAM --- radionuclide --- SPECT --- iodine --- PIB --- breast --- cancer --- PET --- target-specific biomolecules --- immunoPET imaging pharmaceuticals --- production processes --- 124I-labeled monoclonal antibodies --- radiotracers --- AAZTA --- scandium-44 --- FAP --- SA --- DPP --- PREP --- radioiodine labeling --- radioiodination --- biomolecules --- peptides --- proteins --- monoclonal antibodies --- 123,124,125,131I-labeled molecules and biomolecules --- n/a