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Retinoids --- Rétinoïdes --- Retinoids. --- 615.27 --- Agents affecting metabolism and cell functions --- 615.27 Agents affecting metabolism and cell functions --- Rétinoïdes --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein
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This book is the most up-to-date research on vitamin A. It is designed for scientists and researchers to deepen their knowledge in this critical knowledge field, and it is a solid resource that brings together multidisciplinary research, development and innovation for a varied analysis of vitamin A.
Vitamin A. --- Retinol --- Carotenes --- Retinoids --- Vitamins, Fat-soluble --- Beta carotene --- Retinal (Visual pigment) --- Life Sciences --- Vitaminology --- Genetics and Molecular Biology --- Alimentology --- Biochemistry
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Written for comprehensive ophthalmologists and vitreoretinal surgeons, this book discusses state-of-the-art medical and surgical management of cystoid macular edema (CME) and explains the current understanding of the pathophysiology of the condition and methods of diagnosis. The management approach is clearly detailed for each potential presentation, including CME occurring in association with uveitis, diabetes mellitus, vitreoretinal interface changes, retinal vascular occlusions, and lens-induced pathology. The guidance takes full account of the continued expansion in medical treatment options due to the development of new drugs and the increased availability of minimally invasive surgical procedures. Additionally, since therapeutic approaches to CME depend on a clear understanding of pathophysiologic mechanisms and the structural changes in the vitreous and neurosensory retina revealed by imaging studies, these aspects are carefully considered as well.
Edema. --- Retinal (Visual pigment) --- Retinal --- Retinaldehyde --- Retinene --- Vitamin A aldehyde --- Anasarca --- Dropsy --- Hydrops --- Oedema --- Swelling --- Medicine. --- Ophthalmology. --- Medicine & Public Health. --- Retina --- Cytology. --- Aldehydes --- Retinoids --- Visual pigments --- Vitamin A --- Body fluid disorders --- Medicine --- Eye --- Diseases
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Animal physiology. Animal biophysics --- Molecular biology --- Pathological endocrinology --- Receptors, Endogenous Substances --- Hormone receptors --- Retinoids --- Steroid hormones --- Thyroid hormones --- Récepteurs d'hormones --- Rétinoïdes --- Hormones stéroïdes --- Hormones thyroïdiennes --- Receptors --- Récepteurs --- Receptors, Cell Surface. --- Récepteurs d'hormones --- Rétinoïdes --- Hormones stéroïdes --- Hormones thyroïdiennes --- Récepteurs
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Retinoids --- Avitaminosis --- Food --- Age Groups --- Food and Beverages --- Carotenoids --- Deficiency Diseases --- Persons --- Polyenes --- Terpenes --- Cyclohexenes --- Malnutrition --- Pigments, Biological --- Technology, Industry, Agriculture --- Named Groups --- Biological Factors --- Nutrition Disorders --- Cyclohexanes --- Alkenes --- Hydrocarbons --- Nutritional and Metabolic Diseases --- Cycloparaffins --- Chemicals and Drugs --- Organic Chemicals --- Hydrocarbons, Acyclic --- Diseases --- Hydrocarbons, Alicyclic --- Hydrocarbons, Cyclic --- Vitamin A Deficiency --- Vitamin A --- Dietary Supplements --- Infant --- Technology, Industry, and Agriculture
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This book shows how vitamin A deficiency before the vitamin was known to scientists affected millions of people throughout history. It is a story of sailors and soldiers, penniless mothers, orphaned infants, and young children left susceptible to blindness and fatal infections. We also glimpse the fortunate ones who, with ample vitamin A-rich food, escaped this elusive stalker. Why were people going blind and dying? To unravel this puzzle, scientists around the world competed over the course of a century. Their persistent efforts led to the identification of vitamin A and its essential role in health. As a primary focus of today's international public health efforts, vitamin A has saved hundreds of thousands of lives. But, we discover, they could save many more were it not for obstacles erected by political and ideological zealots who lack a historical perspective of the problem.
Vitamin A deficiency --- Vitamin A --- Retinol --- Carotenes --- Retinoids --- Vitamins, Fat-soluble --- Beta carotene --- Retinal (Visual pigment) --- Avitaminosis --- History. --- Health Sciences --- Physiology --- Vitamin A Deficiency--history. --- History, 19th Century. --- Night Blindness --- history --- therapeutic use --- Nutrition --- Ophthalmology --- Biochemistry --- History of Medicine --- Pediatrics --- Public Health --- Vitamins
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The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Medicine. --- Gene expression. --- Nutrition. --- Biochemistry. --- Plant biochemistry. --- Proteins. --- Systems biology. --- Biomedicine. --- Gene Expression. --- Animal Biochemistry. --- Protein Science. --- Plant Biochemistry. --- Systems Biology. --- Retinoids. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Composition --- Biology --- Chemistry --- Medical sciences --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein --- Biological models. --- Models, Biological --- Alimentation --- Food --- Nutrition --- Health --- Physiology --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Genes --- Genetic regulation --- Health aspects --- Expression --- Proteins . --- Nutrition . --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Proteids --- Biomolecules --- Polypeptides --- Proteomics
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Most complex respiratory conditions invoke interactions between genetic and environmental factors, such as smoking, pollution, and diet. There is increasing evidence that diet and nutrition are important factors, not only in disease prevention, but also in their contribution to the chronicity and heterogeneity of lung disorders. Nutrients exert potent effects on metabolism through a variety of regulatory mechanisms, resulting in local and systemic changes in metabolite levels. In this issue of Nutrients, we would like to bring together papers dealing with the topic of “Respiratory Diseases and Nutrition”. We welcome manuscripts detailing human and animal studies focused on the roles of dietary and metabolic factors in the initiation and progression of respiratory diseases, including, but not limited to, chronic obstructive pulmonary disease (COPD) and asthma. In vitro studies aimed at elucidating the potential molecular mechanisms of diet–metabolic interactions are also invited. We welcome different types of manuscript submissions, including original research articles and up-to-date reviews and commentaries.
Research & information: general --- Biology, life sciences --- Food & society --- antioxidant --- chronic obstructive pulmonary disease --- dietary pattern --- inflammation --- lung function --- Mediterranean diet --- nutrition --- oxidative stress --- polyphenol --- polyunsaturated fatty acid --- black ginseng --- oral administration --- influenza A virus --- cytokines --- antiviral --- lung development --- undernutrition --- lung diseases --- ghrelin --- leptin --- GLP-1 --- retinoids --- cholecalciferol --- fetal growth restriction --- respiratory distress syndrome --- lung transplantation --- body mass index --- body composition --- lean body mass --- muscle mass --- sarcopenia --- creatinine-height index --- obesity --- pregnancy --- allergic airway disease --- offspring --- high fat diet --- omega-3 index --- asthma --- fatty acids --- nutritional biomarkers --- pulmonary hypertension --- microbiota --- vitamin C --- vitamin D --- iron --- diet --- bisphenol A --- estrogen --- xenoestrogens --- para-inflammation --- endocrine --- alarmins --- allergy --- microbiome --- nutrients --- prematurity --- bronchopulmonary dysplasia --- weight loss --- children
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Carotenoids are a group of approximately 600 compounds synthesized by photosynthetic organisms. These pigments are abundant in fruits and vegetables, as well as in certain animal products such as eggs and salmon, being responsible for their colorful appearance. The bioactive properties of certain carotenoids in human health are clear, as some of these compounds have antioxidant properties and serve as the only precursors of vitamin A in nature. The aim of this Special Issue entitled “Carotenoids and Human Health” is to provide the scientific community with an updated perspective of this exciting and growing research area. We compiled 19 papers from some of the most prominent scientists in the carotenoid field, including seven literature reviews and 12 original publication, covering topics such as cancer, obesity, vision, cognitive function, and skin health.
membrane transporters --- RAR --- browning --- astaxanthin --- Vitamin A --- case-control study --- ?-carotene --- transcriptomic analysis --- new-born --- carotenes --- cancer-related cognitive impairment --- androgen --- beta-carotene --- eicosapentanoic acid --- mango by-products --- mangiferin --- cell culture --- chronic disease --- Akkermansia --- animal --- intestine --- carotenoids --- alcoholic fatty liver disease --- Phaeodactylum tricornutum --- carotenoid --- tomato --- colourless carotenoids --- preterm mothers --- inflammation --- ?-Cryptoxanthin --- adipocytes --- vitamin A --- gastric cancer --- food ingredients --- brain --- gut microbiota --- zeaxanthin --- nutricosmetics --- brown adipose tissue --- bioactive compounds --- breastfeeding --- aging --- oxidative stress --- retinoids --- phytofluene --- glaucoma --- H. pylori --- retinoid --- tomato extract --- retinol --- ?-cryptoxanthin --- microalgae --- fucoxanthin --- obesity --- macular pigment --- carotene --- photoprotection --- adipose tissue --- lutein --- metabolic syndrome --- Caenorhabditis elegans --- functional foods --- beta-cryptoxanthin --- retinoic acid --- nutrition --- lycopene --- bioavailability --- nutraceuticals --- adipocyte --- ?-tocopherol --- phytoene --- memory --- cosmeceuticals --- antioxidants --- mature milk --- RXR --- fat reduction --- xanthophylls --- colostrum --- smoking --- overweight --- provitamin A --- public health --- Korea --- ?-carotene oxygenase 1 --- cognition --- full-term mothers --- hippocampus --- alpha-carotene --- prostate cancer --- hypertension
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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.
Research & information: general --- Biology, life sciences --- nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- n/a
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