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The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field.This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor.Entries provide information on: Nomenclature and structureIsolationDNA binding propertiesLigandsEx

Nuclear receptors (Biochemistry) --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors

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Nuclear receptors (Biochemistry) --- Récepteurs nucléaires (Biochimie) --- Periodicals --- Périodiques --- Nuclear Receptors --- Research --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors --- Cytology --- nuclear receptors --- General biochemistry

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Histology. Cytology --- Physiology of nerves and sense organs --- Nuclear receptors (Biochemistry) --- Cell receptors --- Récepteurs nucléaires (Biochimie) --- Récepteurs cellulaires --- Receptors, Cytoplasmic and Nuclear --- Periodicals --- Périodiques --- Receptors, Cytoplasmic and Nuclear. --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Cytoplasmic Hormone Receptors --- Cytoplasmic Receptors --- Cytosol and Nuclear Receptors --- Intracellular Membrane Receptors --- Nuclear Hormone Receptors --- Nuclear Receptors --- Receptors, Cytoplasmic --- Receptors, Cytosol and Nuclear --- Receptors, Cytosolic and Nuclear --- Receptors, Intracellular Membrane --- Receptors, Nuclear --- Receptors, Nuclear and Cytoplasmic --- Cytoplasmic and Nuclear Receptors --- Cytosolic and Nuclear Receptors --- Hormone Receptors, Cytoplasmic --- Hormone Receptors, Nuclear --- Nuclear and Cytoplasmic Receptors --- Membrane Receptors, Intracellular --- Receptors, Cytoplasmic Hormone --- Receptors, Nuclear Hormone --- Hormone receptors --- Transcription factors --- Hormones --- Biology. --- Cytology --- Cytoplasmic Receptor --- Nuclear Hormone Receptor --- Nuclear Receptor --- Hormone Receptor, Nuclear --- Receptor, Cytoplasmic --- Receptor, Nuclear --- Receptor, Nuclear Hormone

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This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.

Nuclear receptors (Biochemistry). --- Nuclear hormone receptors --- Receptors, Nuclear (Biochemistry) --- Receptors, Nuclear hormone --- Hormone receptors --- Transcription factors --- Medicine --- Biology --- Molecular biology. --- Metabolism. --- Genetics. --- Cytology. --- Biomedical Research. --- Molecular Biology. --- Genetics and Genomics. --- Cell Biology. --- Research. --- Health Workforce --- Cell biology --- Cellular biology --- Cells --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Biological research --- Biomedical research --- Receptors nuclears (Bioquímica)