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The search for the most favorable therapeutic ratio – at which ablation of cancer is achieved while normal tissues are conserved – has been modern radiation oncology’s equivalent of the quest for the Holy Grail. Our awareness of the late effects of radiation grew during the past century as new modalities were introduced. Heightened normal tissue reactions accompanied the higher rates of cancer ablation achieved by escalation of radiation doses, accelerated fractionated radiotherapy, and aggressive concurrent chemotherapy and radiation regimens. This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. Written by experts in the field, it addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation.

Cancer --- Radiotherapy --- Radiation injuries --- Complications --- Side effects --- Radiation disease --- Radiation sickness --- Radiation syndrome --- Radiation --- Wounds and injuries --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Toxicology --- Radiological services

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Radiation injuries --- Emergency medicine --- Medical emergencies --- Emergency medicine. --- Medical emergencies. --- Radiation injuries. --- Radiation Injuries. --- Emergency Medicine. --- Emergencies. --- Emergency --- Emergency Treatment --- Medicine, Emergency --- Injuries, Radiation --- Radiation Sickness --- Radiation Syndrome --- Injury, Radiation --- Radiation Injury --- Radiation Sicknesses --- Radiation Syndromes --- Sickness, Radiation --- Sicknesses, Radiation --- Syndrome, Radiation --- Syndromes, Radiation --- Atomic Bomb Survivors --- Radioactive Hazard Release --- Emergencies --- First aid in illness and injury --- Medicine --- Critical care medicine --- Disaster medicine --- Radiation disease --- Radiation sickness --- Radiation syndrome --- Radiation --- Wounds and injuries --- Toxicology --- Paramedicine

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"The principal idea behind this volume is to present, in a brief and systematic form, the results from researchers who observed and documented the consequences of the Chernobyl catastrophe. In our view, the need for such an analysis became especially important after September 2005 when the International Atomic Energy Agency (IAEA) and the World Health Organization (WHO) presented and widely advertised "The Chernobyl Forum" report [IAEA (2006), The Chernobyl Legacy: Health, Environment and Socio-Economic Impact and Recommendation to the Governments of Belarus, the Russian Federation and Ukraine 2nd Rev. Ed. (IAEA, Vienna): 50 pp.] because it lacked sufficiently detailed facts concerning the consequences of the disaster"--P. x.

Chernobyl Nuclear Accident. --- Disasters --- Radiation Dosage. --- Radiation Effects. --- Radioactive Hazard Release --- Radiation Injuries. --- Radioactive fallout --- Chernobyl Nuclear Accident, Chornobyl', Ukraine, 1986 --- Nuclear reactor accidents --- Radiation injuries --- Radiation --- Retombées radioactives --- Tchernobyl, Accident nucléaire de, Ukraine, 1986 --- Réacteurs nucléaires --- Mal des rayons --- Rayonnement --- Environmental aspects --- Dosage. --- Accidents --- Aspect de l'environnement --- Dosage --- Chernobyl Nuclear Accident, Chornobylʹ, Ukraine, 1986 --- Dust, Radioactive --- Fallout, Radioactive --- Radioactive dust --- Atomic bomb --- Fallout shelters --- Fission products --- Hydrogen bomb --- Nuclear energy and meteorology --- Radioactive pollution --- Radioactive pollution of the atmosphere --- Radioactive substances --- Nuclear engineering --- Radiotherapy --- Radiation disease --- Radiation sickness --- Radiation syndrome --- Wounds and injuries --- Nuclear reactors --- Nuclear accidents --- Chernobyl Accident, Chornobylʹ, Ukraine, 1986 --- Chernobyl Disaster, Chornobylʹ, Ukraine, 1986 --- Chernobyl Nuclear Disaster, Chornobylʹ, Ukraine, 1986 --- Chernobyl Nuclear Power Plant Accident, Chornobylʹ, Ukraine, 1986 --- Nuclear power plants --- Safety measures --- Measurement --- Physiological effect --- Toxicology

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Low-level radiation --- Health aspects. --- Low-level radiation -- Health aspects. --- Abnormalities, Radiation-Induced --- Radiation, Ionizing --- Physical Phenomenon --- Physical Process --- Physical Concepts --- Concept, Physical --- Concepts, Physical --- Phenomena, Physical --- Phenomenon, Physical --- Physical Concept --- Process, Physical --- Processes, Physical --- Disorders, Congenital --- Congenital Disorders --- Neonatal Diseases and Abnormalities --- Congenital Disorder --- Disorder, Congenital --- Electrical Phenomena --- Electrical Phenomenon --- Electromagnetic Phenomenon --- Electrical Concepts --- Electromagnetic Concepts --- Concept, Electrical --- Concept, Electromagnetic --- Concepts, Electrical --- Concepts, Electromagnetic --- Electrical Concept --- Electromagnetic Concept --- Electromagnetic Phenomenas --- Phenomena, Electrical --- Phenomena, Electromagnetic --- Phenomenon, Electrical --- Phenomenon, Electromagnetic --- Health, Radiologic --- Radiological Health --- Health, Radiological --- Radiations --- Ionizing Radiation --- Ionizing Radiations --- Radiations, Ionizing --- Effects, Radiation --- Effect, Radiation --- Radiation Effect --- Radiation-Induced Abnormalities --- Abnormalities, Radiation Induced --- Abnormality, Radiation-Induced --- Radiation Induced Abnormalities --- Radiation-Induced Abnormality --- Radiation, Low-level --- Radiation Effects --- Neoplasms, Radiation-Induced --- Neoplasms --- Radiation Injuries --- Congenital Abnormalities --- Radiation --- Radiologic Health --- Electromagnetic Phenomena --- Diseases --- Wounds and Injuries --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Public Health --- Physical Phenomena --- Environment and Public Health --- Phenomena and Processes --- Health Care --- Toxicology & Public Health --- Health & Biological Sciences --- Health aspects --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Physical Processes --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Injuries and Wounds --- Injuries, Wounds --- Research-Related Injuries --- Wounds --- Wounds and Injury --- Wounds, Injury --- Injuries --- Trauma --- Injuries, Research-Related --- Injury --- Injury and Wounds --- Injury, Research-Related --- Research Related Injuries --- Research-Related Injury --- Traumas --- Wound --- Electromagnetics --- Abnormalities, Congenital --- Defects, Congenital --- Birth Defects --- Congenital Defects --- Deformities --- Abnormality, Congenital --- Birth Defect --- Congenital Abnormality --- Congenital Defect --- Defect, Birth --- Defect, Congenital --- Defects, Birth --- Deformity --- Injuries, Radiation --- Radiation Sickness --- Radiation Syndrome --- Injury, Radiation --- Radiation Injury --- Radiation Sicknesses --- Radiation Syndromes --- Sickness, Radiation --- Sicknesses, Radiation --- Syndrome, Radiation --- Syndromes, Radiation --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Cancer, Radiation-Induced --- Radiation-Induced Neoplasms --- Radiation-Induced Cancer --- Cancer, Radiation Induced --- Cancers, Radiation-Induced --- Neoplasm, Radiation-Induced --- Neoplasms, Radiation Induced --- Radiation Induced Cancer --- Radiation Induced Neoplasms --- Radiation-Induced Cancers --- Radiation-Induced Neoplasm --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- First Aid --- Traumatology --- Dose Hypofractionation --- Fetal Diseases --- Infant, Newborn, Diseases --- Teratogenesis --- Radioactive Hazard Release --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Medical Oncology --- Radiation Genetics --- Radiation Tolerance --- Radiation Dose Hypofractionation --- Atomic Bomb Survivors --- Fetal Anomalies --- Fetal Malformations --- Anomaly, Fetal --- Fetal Anomaly --- Fetal Malformation --- Malformation, Fetal