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Virus inhibitors --- Virus diseases --- Antiviral agents --- Virus Inhibitors --- Virus Diseases --- Antiviral Agents --- immunology --- Antiviral Agents. --- Virus research --- Agents antiviraux --- Antiviraux --- Maladies à virus --- Virus --- Antiviral agents. --- Virus diseases. --- Virus inhibitors. --- immunology. --- Périodiques. --- Inhibiteurs --- Immunologie --- Antiviruses --- Viral diseases --- Viral infections --- Virus infections --- Antiviral drugs --- Antivirals --- Antiviral Drugs --- Agents, Antiviral --- Drugs, Antiviral --- Viruses --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Anti-infective agents --- Interferon Inducers --- Virus Inactivation --- Chemotherapy --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Agent, Antiviral --- Drug, Antiviral --- Virus Diseases. --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Antiviraux. --- Periodicals. --- Viral Protease Inhibitors. --- Inhibitor of Viral Protease --- Virus Protease Inhibitors --- Inhibitors, Viral Protease --- Inhibitors, Virus Protease --- Protease Inhibitor, Viral --- Protease Inhibitors, Viral --- Protease Inhibitors, Virus --- Viral Protease Inhibitor --- Viral Proteases --- antagonists & inhibitors --- Viral Inactivation --- Inactivation, Viral --- Inactivation, Virus --- Maladies à virus --- Périodiques. --- Viral Protease Inhibitors

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Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest.  In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

Bones -- Cancer -- Treatment. --- Bones -- Cancer. --- Protease inhibitors --- Enzyme Inhibitors --- Proteins --- Medicine --- Pathologic Processes --- Receptors, Cell Surface --- Hydrolases --- Enzymes --- Amino Acids, Peptides, and Proteins --- Molecular Mechanisms of Pharmacological Action --- Pathological Conditions, Signs and Symptoms --- Health Occupations --- Membrane Proteins --- Enzymes and Coenzymes --- Pharmacologic Actions --- Disciplines and Occupations --- Chemicals and Drugs --- Diseases --- Chemical Actions and Uses --- Peptide Hydrolases --- Receptors, Proteinase-Activated --- Protease Inhibitors --- Pathology --- Carrier Proteins --- Inflammation --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Therapeutic use --- Proteolytic enzymes. --- Peptide hydrolases --- Proteases --- Medicine. --- Immunology. --- Infectious diseases. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Infectious Diseases. --- Cytology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology

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The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.

Protease inhibitors --- Cancer --- Therapeutic use. --- Chemotherapy. --- Antineoplastic agents --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Enzyme inhibitors --- Treatment --- Inhibitors --- Oncology. --- Drug interactions. --- Toxicology. --- Medicine. --- Cancer Research. --- Drug Resistance. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Interactions, Drug --- Drugs --- Tumors --- Toxicology --- Side effects --- Health Workforce --- Cancer research. --- Drug resistance. --- Pharmacology. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Resistance to drugs --- Cancer research --- Physiological effect

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Angiotensin II --- Angiotensin-Converting Enzyme Inhibitors --- Brain --- Central nervous system --- Cerebrovascular Circulation --- Renin-Angiotensin System --- Angiotensin-converting enzyme --- Hypertension --- Hypertension artérielle --- therapeutic use --- blood supply --- Drug effects --- drug effects --- Inhibitors --- Chemotherapy --- Chimiothérapie --- Angiotensin-Converting Enzyme Inhibitors. --- Hypertension artérielle --- Chimiothérapie --- Angiotensin I-Converting Enzyme Inhibitors --- Angiotensin-Converting Enzyme Antagonists --- Antagonists, Angiotensin-Converting Enzyme --- Antagonists, Kininase II --- Inhibitors, ACE --- Inhibitors, Angiotensin-Converting Enzyme --- Inhibitors, Kininase II --- Kininase II Antagonists --- ACE Inhibitors --- Kininase II Inhibitors --- Angiotensin Converting Enzyme Antagonists --- Angiotensin Converting Enzyme Inhibitors --- Angiotensin I Converting Enzyme Inhibitors --- Antagonists, Angiotensin Converting Enzyme --- Enzyme Antagonists, Angiotensin-Converting --- Enzyme Inhibitors, Angiotensin-Converting --- Inhibitors, Angiotensin Converting Enzyme --- Peptidyl-Dipeptidase A --- Antihypertensive Agents --- Angiotensin II Type 1 Receptor Blockers --- ACE inhibitors --- Hypotensive agents --- Protease inhibitors --- antagonists & inhibitors --- Central Nervous System --- Renin-Angiotensin System. --- therapeutic use. --- blood supply. --- drug effects. --- ACE Inhibitor --- Angiotensin Converting Enzyme Inhibitor --- Angiotensin I-Converting Enzyme Inhibitor --- Angiotensin-Converting Enzyme Inhibitor --- Kininase II Inhibitor --- Angiotensin I Converting Enzyme Inhibitor --- Enzyme Inhibitor, Angiotensin-Converting --- II Inhibitor, Kininase --- Inhibitor, ACE --- Inhibitor, Angiotensin-Converting Enzyme --- Inhibitor, Kininase II

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Human milk is uniquely tailored to meet infants’ specific nutritional requirements. However, it is more than just “milk”. This dynamic and bioactive fluid allows mother–infant signalling over lactation, guiding the infant in the developmental and physiological processes. It exerts protection and life-long biological effects, playing a crucial role in promoting healthy growth and optimal cognitive development. The latest scientific advances have provided insight into different components of human milk and their dynamic changes over time. However, the complexity of human milk composition and the synergistic mechanisms responsible for its beneficial health effects have not yet been unravelled. Filling this knowledge gap will shed light on the biology of the developing infant and will contribute to the optimization of infant feeding, particularly that of the most vulnerable infants. Greater understanding of human milk will also help in elucidating the best strategies for its storage and handling. The increasing knowledge on human milk’s bioactive compounds together with the rapidly-advancing technological achievements will greatly enhance their use as prophylactic or therapeutic agents. The current Special Issue aims to welcome original works and literature reviews further exploring the complexity of human milk composition, the mechanisms underlying the beneficial effects associated with breastfeeding, and the factors and determinants involved in lactation, including its promotion and support.

high pressure processing --- n/a --- lipids --- supplementation --- protective factors --- infant --- carbohydrate --- mothers --- antioxidant capacity --- protein --- fat --- cytokines --- bioactive factors --- late preterm --- zinc --- infants --- docosahexaenoic acid (DHA) --- pregnancy --- eicosapentaenoic acid (EPA) --- Lipidomics --- magnesium --- omega-3 fatty acids --- vitamin D deficiency --- flow injection analysis --- human milk benefits --- multiple source method --- 3?-sialyllactose (3?SL) --- milk banking --- milk group --- pasteurization --- video instruction --- Milk Fat Globule Membrane --- bile salt stimulated lipase --- breastfeeding difficulties --- breastfeeding support --- prematurity --- carotenoids --- hormones --- phosphocholine --- amino acids --- targeted metabolomics --- high-performance liquid chromatography (HPLC) --- choline --- selenium --- ?-linolenic acid --- arachidonic acid (ARA) --- docosahexaenoic acid --- human milk fortification --- protease inhibitors --- celiac disease --- copper --- term --- adipokines --- iodine --- mammary gland --- nutritional status --- food frequency questionnaire --- neonate --- early breastfeeding cessation --- prospective study --- breastfeeding --- mothers’ own milk --- disialyllacto-N-tetraose (DSLNT) --- country --- lactating women --- undernourishment --- proteases --- preterm --- expressing --- dietary assessment --- retinol --- body composition --- duration of lactation --- passive immunization --- 2?-fucosyllactose (2?FL) --- phosphorus --- clinical trial --- growth factors --- infant formula --- digestive tract --- human milk oligosaccharides (HMO) --- sodium --- nutrition --- eicosapentaenoic acid --- lipid metabolites --- lactation --- nervonic acid --- ?-tocopherol --- macronutrients --- glycoprotein --- term infant --- term infants --- maternal diet --- promotion of breastfeeding --- potassium --- antioxidants --- maternal immunoglobulins --- Human Milk --- human milk --- Phospholipids --- flu vaccine --- lactational stage --- lactose --- storage --- dietary intake --- Preterm infant --- immune-active proteins --- colostrum --- human milk fat --- inadequate intake --- milk therapy --- endogenous peptide --- calcium --- fatty acids --- breast milk --- pumping --- secretor --- LC-MS --- n-9 fatty acid --- Lewis --- donor human milk --- antenatal --- online --- iron --- growth --- donor milk --- mothers' own milk