Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Plasminogen Activator, Tissue-Type --- Thrombosis --- Thrombolytic therapy. --- Tissue plasminogen activator --- Thrombolyse --- therapeutic use. --- drug therapy. --- Therapeutic use. --- Tissue Plasminogen Activator --- Thrombolytic therapy --- -Activator, Tissue plasminogen --- Plasminogen activator, Tissue-type --- Tissue-type plasminogen activator --- TPA (Biochemistry) --- Circulating anticoagulants --- Endothelium --- Plasminogen activators --- Fibrinolytic therapy --- Thrombolysis --- Chemotherapy --- Fibrinolysis --- Therapeutic use --- -therapeutic use. --- Activator, Tissue plasminogen --- drug therapy --- therapeutic use

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This is a review of the topic of fibrinolysis contributed by authors who are specialized in the clinical and basic studies of this topic. These include: the endothelial receptor of tissue plasminogen activator, by Dr. Katherine Hajjar; regulation of S100 by pml-rar-alpha oncoprotein, by Dr. O’Connell; receptor of urokinase type plasminogen activator, by Dr. M. Ploug et al.; tissue plasminogen activator induction in purjinjen neuron, by Dr. Seeds; fibrinolysis from the blood to the brain, by Dr. Robert Metcalf; tissue plasminogen activator induces the opening of the blood–brain barrier, by Dr. M. Yepes; fibrinolysis shutdown in trauma: a historical review and clinical application, by Drs. Hunter Moore and Ernest Moore; fibrinolysis in immunity, by Drs. K. Kolev and Robert Medcalf; the role of plasminogen activator inhibitor 1, by Drs. M. Erin, A.E. Boe, and E.A. Klyachko; and finally, persistent fibrinolysis shutdown is associated with increased mortality in severely injured trauma patients, by J.P. Meizoso.

Research & information: general --- Biology, life sciences --- COVID-19 --- fibrinolysis --- renin-aldosterone-angiotensin-system (RAAS) --- plasminogen activator inhibitor 1 (PAI-1) --- urokinase plasminogen activator --- urokinase plasminogen activator receptor --- plasminogen activator inhibitor-1 --- acute lung injury and repair and pleural injury and pleural organization --- PAI-1 --- cardiovascular disease --- cancer --- inflammation --- fibrosis --- aging --- obstructive sleep apnoea --- OSA --- coagulation --- platelets --- brown adipose tissue --- obesity --- plasminogen activation --- immune response --- thrombin activatable fibrinolysis inhibitor --- TAFI --- proCPU --- proCPB --- proCPR --- carboxypeptidase --- uPA --- uPAR --- PA system --- tissue-type plasminogen activator (tPA) --- urokinase-type plasminogen activator (uPA) --- neurodegeneration --- thrombin --- shear --- clot retraction --- Factor XIII --- clot stability --- NETs --- plasmin --- plasminogen activator --- PAI-2 --- antiplasmin

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Gastrointestinal (GI) cancer is a major cause of morbidity and mortality in the world. Since early diagnosis and optimal treatment selection are crucial to improving the prognosis of these diseases, the discovery of useful biomarkers has the potential to greatly reduce their burden. Recent technical and mechanical developments have allowed for the detection of tiny differences in various factors modified in physical conditions, which could contribute to the discovery of novel biomarkers for some diseases.In this Special Issue, we aim to focus on novel biomarkers for GI cancers, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and biliary cancer. In addition, any samples (tissue, blood, urine and feces) are useful as biomarker sources, although body-fluid-based biomarkers are promising as diagnostic biomarkers due to their noninvasiveness. This Special Issue aims to collect novel insights clarifying the current situation and future perspective in this field.

Medicine --- Oncology --- colorectal cancer --- advanced adenoma --- screening --- stool --- mRNA --- n/a --- cancer screening --- cirrhosis --- AFP --- machine learning --- MALDI-TOF --- proteomics --- CXCR4 --- prognosis --- overall survival --- rectal cancer --- neoadjuvant chemoradiation --- mouse model --- biomarkers --- urokinase plasminogen activator (uPA) --- urokinase plasminogen activator receptor (uPAR) --- plasminogen activator inhibitor type 1 (PAI-1) --- circulating tumour cell (CTC) --- gastric cancer --- oesophageal cancer --- serine proteases --- tumour microenvironment --- serpins --- biomarker --- chemoresistance --- liquid biopsy --- microRNA --- long non-coding RNA --- colorectal neoplasms --- cancer screening tests --- early detection of cancer --- precision medicine --- unfolded protein --- hepatocellular cancer --- GSVA --- unfolded protein score --- epigenetic regulation genes --- somatic mutations --- molecular genetic markers --- extracellular vesicles --- microbiome --- 16S rRNA amplicon --- metagenomics --- liver fibrosis --- hepatocellular carcinoma --- recurrence --- SHG/TPEF microscopy --- artificial intelligence --- advanced gastric cancer --- targeted therapy --- urinary miRNA --- miR-129-1-3p --- miR-566

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Stress, high blood pressure, smoking, pollution, fast foods, overweight, excessive travelling, surgery, less movement are common features in our modern life. These features are risky for blood clotting disorders. According to WHO, over 29% of the total mortalities worldwide are due to thrombosis. By the year, 2020 cardiovascular diseases (CVDs) may cause an estimated 25 million deaths per year, thus antithrombotic therapy is of great interest. The available thrombolytic agents such as urokinase are highly expensive, antigenic, quite unspecific, pyretogenic and hemorrhagenic. Therefore, the production of fibrinolysing enzymes, which rapidly dissolute thrombi within the vascular tree, without the detriments by microorganisms, as described in this book, is the desirable aim of today’s research.

Fibrinolytic agents. --- Fibrinolytic agents --- Organisms --- Fibrin Modulating Agents --- Endopeptidases --- Hematologic Agents --- Plasminogen Activators --- Cardiovascular Agents --- Blood Coagulation Factors --- Therapeutic Uses --- Molecular Mechanisms of Pharmacological Action --- Peptide Hydrolases --- Pharmacologic Actions --- Blood Proteins --- Hydrolases --- Chemical Actions and Uses --- Enzymes --- Proteins --- Chemicals and Drugs --- Enzymes and Coenzymes --- Amino Acids, Peptides, and Proteins --- Fibrinolytic Agents --- Streptokinase --- Bacteria --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Microbiology & Immunology --- Thrombosis. --- Anticoagulants (Medicine) --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Antithrombotics --- Fibrinolytic enzymes --- Fibrinolytics --- Thrombolytic agents --- Thrombolytics --- Medicine. --- Human physiology. --- Medical microbiology. --- Cardiology. --- Hematology. --- Biomedicine. --- Medical Microbiology. --- Human Physiology. --- Haematology --- Internal medicine --- Blood --- Heart --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Diseases --- Hematologic agents --- Cardiovascular system --- Protein C deficiency --- Protein S deficiency --- Coagulation --- Microbiology. --- Microbial biology --- Microorganisms

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, among others, is widespread. Several researchers have described the advantages of different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving therapeutic effects. Their use in the cosmetic field is also promising, owing to their moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only a few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies.Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipid-based nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises the comparison between different studies.This book brings together the latest research and reviews that report on in vitro, ex vivo, and in vivo preclinical studies using lipid-based nanosystems. Readers can find up-to-date information on the most common experiments performed to predict the clinical behavior of lipid-based nanosystems. A series of 15 research articles and a review are presented, with authors from 15 different countries, which demonstrates the universality of the investigations that have been carried out in this area.

Technology: general issues --- nanostructured lipid carriers (NLC) --- formulation optimization --- rivastigmine --- quality by design (QbD) --- nasal route --- nose-to-brain --- N-alkylisatin --- liposome --- urokinase plasminogen activator --- PAI-2 --- SerpinB2 --- breast cancer --- liposomes --- target delivery nanosystem --- FZD10 protein --- colon cancer therapy --- supersaturation --- silica-lipid hybrid --- spray drying --- lipolysis --- lipid-based formulation --- fenofibrate --- mesoporous silica --- oral drug delivery --- hyaluronic acid --- drug release --- light activation --- stability --- mobility --- biocorona --- dissolution enhancement --- phospholipids --- solid dosage forms --- porous microparticles --- nanoemulsion(s) --- phase-behavior --- DoE --- D-optimal design --- vegetable oils --- non-ionic surfactants --- efavirenz --- flaxseed oil --- nanostructured lipid carriers --- nanocarrier --- docohexaenoic acid --- neuroprotection --- neuroinflammation --- fluconazole --- Box‒Behnken design --- nanotransfersome --- ulcer index --- zone of inhibition --- rheological behavior --- ex vivo permeation --- nanomedicine --- cancer --- doxorubicin --- melanoma --- drug delivery --- ultrasound contrast agents --- phospholipid coating --- ligand distribution --- cholesterol --- acoustic response --- microbubble --- lipid phase --- dialysis --- ammonia --- intoxication --- cyanocobalamin --- vitamin B12 --- atopic dermatitis --- psoriasis --- transferosomes --- lipid vesicles --- skin topical delivery --- oligonucleotide --- self-emulsifying drug delivery systems --- hydrophobic ion pairing --- intestinal permeation enhancers --- Caco-2 monolayer --- clarithromycin --- solid lipid nanoparticles --- optimization --- permeation --- pharmacokinetics --- follicular targeting --- dexamethasone --- alopecia areata --- lipomers --- lipid polymer hybrid nanocapsules --- biodistribution --- skin --- ethyl cellulose --- n/a