Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibition strategies are one of the fastest expanding areas in the field of of drugs that show considerable promise. This Special Issue will focus on the recent advances in the discovery and development of protease inhibitors, covering the synthesis of protease inhibitors, the design of new chemical entities acting as inhibitors of special/particular types of proteases, and their mode of actions (Frolova et al. 2020; Slapak et al. 2020; Künnapuu et al. 2021). In addition, the new applications of these interesting compounds/biomolecules and their limitations have been discussed and described (Wang et al. 2020; Bartošová-Sojková et al. 2021).

Research & information: general --- MMP --- MMP2 --- MMP9 --- MMP7 --- MMP14 --- matrix metalloproteases --- PDAC --- pancreatic cancer --- Bowman–Birk inhibitor --- ranacyclin --- trypsin inhibitor --- structure–activity relationship --- synergistic effect --- Gentamicin --- matrix metalloproteinase --- extracellular matrix --- nuclei --- cancer --- apoptosis --- immune response --- cysteine protease inhibitor --- stefin --- signal peptide --- parasite --- phylogenetic analysis --- diversification --- protein structure --- vascular endothelial growth factors (VEGFs) --- VEGF-A --- PlGF --- VEGF-B --- VEGF-C --- VEGF-D --- angiogenesis --- lymphangiogenesis --- CCBE1 --- proteases --- ADAMTS3 --- plasmin --- cathepsin D --- KLK3 --- prostate-specific antigen (PSA) --- thrombin --- wound healing --- metastasis --- proteolytic activation --- vascular biology --- lymphedema

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Pseudorabies virus (PRV) is an important swine pathogen that impacts swine industry worldwide. PRV belongs to the alphaherpes virus subfamily of the herpesviruses that has been widely used as a model herpes virus. Most recently, PRV has been reported sporadically spillover into human and other animals. This book collects the newest advances in the field of pseudorabies virus research, including critical reviews and research on viral evolution, replication, virus–host interaction, pathogenesis and immunity, and novel antiviral strategies.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- pseudorabies virus --- Liver X receptors --- clathrin-coated pits --- viral entry --- innate immune response --- type I interferons --- apoptosis --- autophagy --- premature termination codon --- genetic code expansion --- virus isolation --- pathogenicity --- mortality --- inflammatory response --- Huaier polysaccharide --- antiviral --- infection --- Vero cell --- TMT-based proteomic analysis --- differentially expressed proteins --- antiviral breeding --- genetic modification --- nectin1 --- pig --- PRV --- disease resistance --- seroprevalence --- epidemiology --- phylogenetic analysis --- variants --- ICP0 protein --- P65 --- NF-κB signaling pathway --- complete genome sequencing --- gene recombination --- variant strain --- genomics --- vaccination --- transmission --- zoonosis --- itch --- mouse --- histamine --- dorsal root ganglion --- metabolomic analysis --- UHPLC-QE-MS --- PK-15 cells --- latent infection --- latency-associated transcripts --- non-coding RNA --- latency --- miRNA --- chromatin --- immune regulation --- variation --- human pseudorabies encephalitis --- pseudorabies virus (PRV) --- tegument protein UL13 --- RIG-I --- MDA5 --- NF-κB --- pathogenesis --- prevention and control --- Aujeszky’s disease --- epidemiological characteristics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Chloroplasts in photosynthetic organisms and mitochondria in a vast majority of eukaryotes, contain part of the genetic material of a eukaryotic cell. The organisation and inheritance patterns of this organellar DNA are quite different to that of nuclear DNA. Present-day chloroplast and mitochondrial genomes contain only a few dozen genes. Nevertheless, these organelles harbor several thousand proteins, the vast majority of them encoded by the nucleus. As a result, the expression of nuclear and organelle genomes has to be very precisely coordinated. The selection of experimental and review papers of this book covers a wide range of topics related to chloroplasts and plant mitochondria research, illustrating recent advances and diverse insights into the field of organelle genetics in plants. These works represent some of the latest research on the genetics, genomics, and biotechnology of plant mitochondria and chloroplasts, and they are of significant broad interest for the community of plant scientists, especially for those working in the subjects related to organelle genetics

Research & information: general --- Salt stress --- organellar gene expression (OGE) --- Arabidopsis --- rice --- mitochondrial transcription termination factors (mTERFs) --- pentatricopeptide repeat (PPR) proteins --- DEAD-box RNA helicases (RHs)-containing proteins --- RNA-recognition motifs (RRMs)-containing proteins --- SIGMA FACTOR 5 --- PLASTID-SPECIFIC RIBOSOMAL PROTEIN 2 --- chloroplast genome --- free-standing ORFs --- introns --- phylogenetic analysis --- taxonomic study --- Trentepohlia odorata --- Trentepohliales --- Macrosolen --- Macrosolen cochinchinensis --- Macrosolen tricolor --- Macrosolen bibracteolatus --- Santalales --- gene loss --- phylogenetic relationship --- Utricularia amethystina --- Lentibulariaceae --- chloroplast phylogenomics --- organelle genome --- carnivorous plants --- polymorphic species --- intraspecific variation --- ndh genes --- genome structure --- genome evolution --- DNA transfer --- nuclear integrants of plastid DNA (NUPT) --- nuclear integrants of mitochondrial DNA (NUMT) --- legumes --- clover --- organelle genetics --- mitochondria --- endosymbiotic gene transfer --- gene fission --- common bean --- Phaseolus vulgaris --- mitochondrial genome --- comparative genomics --- phylogeny --- soybean --- yellow leaf mutant --- photosynthesis --- chloroplast RNA editing --- chloroplast --- SWNTs --- morphogenic regulators --- CRISPR --- protoplast regeneration --- chloroplast gene expression --- environmental stress response --- transcription --- RNA metabolism --- translation --- complex I --- intron splicing --- maturase --- NDH --- RNA editing --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cytogenetics --- Phylogeny --- Biology --- Cytogénétique --- Biologie --- Periodicals. --- Classification --- Molecular aspects --- Périodiques --- Aspect moléculaire --- genetics --- cytogenetics --- Phylogenies --- Phylogeography --- Cytogenetic --- Cytogenetic Analysis --- Chromosome Disorders --- Sex Chromosome Disorders --- Life sciences --- Biomass --- Life (Biology) --- Natural history --- Cytology --- Genetics --- Cytogenetics. --- Molecular aspects. --- Molecular systematics --- Molecular biology --- Phylogenomics --- Phylogenomic --- Community Phylogenetics --- Molecular Phylogenetics --- Phylogenetic Analyses --- Phylogenetic Analysis --- Phylogenetic Clustering --- Phylogenetic Comparative Analysis --- Phylogenetic Comparative Methods --- Phylogenetic Distance --- Phylogenetic Generalized Least Squares --- Phylogenetic Groups --- Phylogenetic Incongruence --- Phylogenetic Inference --- Phylogenetic Networks --- Phylogenetic Reconstruction --- Phylogenetic Relatedness --- Phylogenetic Relationships --- Phylogenetic Signal --- Phylogenetic Structure --- Phylogenetic Tree --- Phylogenetic Trees --- Analyse, Phylogenetic --- Analysis, Phylogenetic --- Analysis, Phylogenetic Comparative --- Clustering, Phylogenetic --- Community Phylogenetic --- Comparative Analysis, Phylogenetic --- Comparative Method, Phylogenetic --- Distance, Phylogenetic --- Group, Phylogenetic --- Incongruence, Phylogenetic --- Inference, Phylogenetic --- Method, Phylogenetic Comparative --- Molecular Phylogenetic --- Network, Phylogenetic --- Phylogenetic Analyse --- Phylogenetic Clusterings --- Phylogenetic Comparative Analyses --- Phylogenetic Comparative Method --- Phylogenetic Distances --- Phylogenetic Group --- Phylogenetic Incongruences --- Phylogenetic Inferences --- Phylogenetic Network --- Phylogenetic Reconstructions --- Phylogenetic Relatednesses --- Phylogenetic Relationship --- Phylogenetic Signals --- Phylogenetic Structures --- Phylogenetic, Community --- Phylogenetic, Molecular --- Reconstruction, Phylogenetic --- Relatedness, Phylogenetic --- Relationship, Phylogenetic --- Signal, Phylogenetic --- Structure, Phylogenetic --- Tree, Phylogenetic --- Phylogeny.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

PhytoKeys is a peer-reviewed, open-access journal launched to accelerate research and free information exchange in taxonomy, phylogeny, biogeography and evolution of higher plants and lichens. Journal will publish papers in systematic botany containing taxonomic/floristic data on any taxon of any geological age from any part of the world.

Plants --- Lichens --- Botany --- Biodiversity --- Plantes --- Botanique --- Biodiversité --- Classification --- Periodicals. --- Nomenclature --- Periodicals --- Périodiques --- Plants. --- Classification. --- Phylogeny. --- systematic botany --- plants phylogeny --- plant taxonomy --- Phylogenies --- Systematics --- Taxonomy --- Classifications --- Taxonomies --- Plant --- Biological diversification --- Biological diversity --- Biotic diversity --- Diversification, Biological --- Diversity, Biological --- Macro-lichens --- Macrolichens --- Microlichens --- Flora --- Plant kingdom --- Plantae --- Vascular plants --- Vegetable kingdom --- Vegetation --- Wildlife --- Phylogeography --- Phylogeny --- Plant Proteins --- Ethnopharmacology --- Biology --- Biocomplexity --- Ecological heterogeneity --- Numbers of species --- Cryptogams --- Organisms --- Biodiversity. --- Botany. --- Botanical science --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Natural history --- Phylogenomics --- Phylogenomic --- Botany - General --- Community Phylogenetics --- Molecular Phylogenetics --- Phylogenetic Analyses --- Phylogenetic Analysis --- Phylogenetic Clustering --- Phylogenetic Comparative Analysis --- Phylogenetic Comparative Methods --- Phylogenetic Distance --- Phylogenetic Generalized Least Squares --- Phylogenetic Groups --- Phylogenetic Incongruence --- Phylogenetic Inference --- Phylogenetic Networks --- Phylogenetic Reconstruction --- Phylogenetic Relatedness --- Phylogenetic Relationships --- Phylogenetic Signal --- Phylogenetic Structure --- Phylogenetic Tree --- Phylogenetic Trees --- Analyse, Phylogenetic --- Analysis, Phylogenetic --- Analysis, Phylogenetic Comparative --- Clustering, Phylogenetic --- Community Phylogenetic --- Comparative Analysis, Phylogenetic --- Comparative Method, Phylogenetic --- Distance, Phylogenetic --- Group, Phylogenetic --- Incongruence, Phylogenetic --- Inference, Phylogenetic --- Method, Phylogenetic Comparative --- Molecular Phylogenetic --- Network, Phylogenetic --- Phylogenetic Analyse --- Phylogenetic Clusterings --- Phylogenetic Comparative Analyses --- Phylogenetic Comparative Method --- Phylogenetic Distances --- Phylogenetic Group --- Phylogenetic Incongruences --- Phylogenetic Inferences --- Phylogenetic Network --- Phylogenetic Reconstructions --- Phylogenetic Relatednesses --- Phylogenetic Relationship --- Phylogenetic Signals --- Phylogenetic Structures --- Phylogenetic, Community --- Phylogenetic, Molecular --- Reconstruction, Phylogenetic --- Relatedness, Phylogenetic --- Relationship, Phylogenetic --- Signal, Phylogenetic --- Structure, Phylogenetic --- Tree, Phylogenetic --- Floristic botany