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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Biology, life sciences --- breast cancer --- mammary gland --- development --- imaging --- microenviroment --- organoid --- signaling --- omics

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Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.

n/a --- tissue engineering --- microfluidic device --- ischemia/reperfusion injury --- syringe pump --- liver-on-a-chip --- vacuum chuck --- epithelial–endothelial interface --- vessel branching --- organs-on-chips --- nanogrooves --- passive delivery --- functional neuron imaging --- organ-on-a-chip --- lung epithelial cell --- MEMS --- drug absorption --- strain --- 3D cell culture system --- mechanical cue --- multi-culture --- angiogenesis --- high-throughput screening --- fluoroelastomer --- membranes --- cell culture --- paracellular/transcellular transport --- beating force --- microfabrication --- drug hepatotoxicity --- biomimetic oxidation --- compression --- microfluidics --- surfactant protein --- PDMS --- neuronal cell networks --- neuronal guidance --- trans-epithelial electrical resistance --- spheroid array --- organ-on-a-chip (OOC) --- biomechanics --- cell --- organ-on-chips --- organ-on-chip --- stretch --- shear stress --- shear flow --- image-based screening --- drug metabolism --- vascularization --- human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) --- stress --- barrier permeability --- bio-mechanical property --- cardiac 3D tissue --- endothelial cell activation --- organoid --- silicon --- lattice light-sheet microscopy --- integrated pump --- SH-SY5Y cells --- thrombolysis --- 3D cell culture --- neuronal cells --- drug efficacy --- vascularized tumor model --- epithelial-endothelial interface

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To celebrate the publication of 20,000 articles in Applied Sciences, we launched this Special Issue “Celebrating Applied Sciences Reaching Its 20,000 Article Milestone: Feature Papers of the Applied Biosciences and Bioengineering Section”. We have invited well-known experts in different areas of interest covered in “Applied Biosciences and Bioengineering” to submit their original research papers and review articles of the highest quality in celebrating together with our readers on this special occasion. This Special Issue has collected more than 10 papers featuring important and recent developments or achievements in biosciences and bioengineering, with a special emphasis on recently discovered techniques or applications.

Technology: general issues --- Biotechnology --- biothiols --- blood plasma --- gold nanoparticles --- colorimetric probes --- chaperone system --- Hsp60 --- gastritis --- gastric dysplasia --- gastric carcinogenesis --- intestinal metaplasia --- LAMP --- Salmonella --- ISO 16140:2016 --- food-borne --- validation --- specificity --- sensitivity --- accuracy --- kit --- elderberry --- Sambucus nigra L. --- juice concentrate --- storage effect --- phenolic compounds --- berries --- anthocyanins’ stability --- polymeric color --- ABTS•+ antioxidant capacity --- endothelial glycocalyx --- inflammatory response --- fluid loading --- surgery --- post-operative --- albumin extravasation --- serum HSP90 --- gamma-delta T cells --- acute lymphoblastic leukaemia --- halophyte --- sea purslane --- minerals --- antioxidant activity --- novel ingredient --- epilepsy --- systems biology --- protein–protein interactions --- CNS --- Gibbs homology --- drug targets --- anti-epileptic drugs --- periodontitis --- inflammation --- oils --- volatile --- heart disease risk factors --- asthma --- chronic obstructive pulmonary disease --- COPD --- epithelial–mesenchymal trophic unit --- muco-microbiotic layer --- nanovesicles --- exosomes --- outer membrane vesicles --- microbiota --- spheroid --- organoid --- van der Waals force --- fluoropolymers --- adhesion --- microstamp --- extracellular vesicles --- liquid biopsy --- biomarkers --- tumor progression --- metastasis --- drug delivery --- halloysite --- nanoclay --- regenerative medicine --- tissue engineering --- wound healing --- stroke --- yoga --- balance disability --- depression --- levetiracetam --- critically ill patients --- population pharmacokinetic modeling --- simulated dosage schemes --- intensive care unit --- n/a --- anthocyanins' stability --- protein-protein interactions --- epithelial-mesenchymal trophic unit