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Methoxyhydroxyphenylglycol --- Methoxyhydroxyphenylglycol --- Norepinephrine --- Adrenergic mechanisms. --- Methoxyhydroxyphenylglycol --- Methoxyhydroxyphenylglycol --- Norepinephrine --- Analysis. --- Diagnostic use. --- Metabolism. --- analysis. --- diagnostic use. --- metabolism.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Endocrinology --- Glucocorticoids --- Growth hormone --- Sympathetic innervation --- Galectins --- Thymus --- Norepinephrine --- Ephrins --- Diabetes --- Infectious diseases --- Cytokines

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Receptors, Adrenergic --- Drug effects --- Congresses. --- Physiology --- Receptors, Adrenergic. --- 615.21 --- Adrenergic Receptor --- Epinephrine Receptors --- Norepinephrine Receptors --- Adrenergic Receptors --- Adrenoceptors --- Receptors, Epinephrine --- Receptors, Norepinephrine --- Receptor, Adrenergic --- Epinephrine --- Norepinephrine --- Sympathomimetics --- Racepinephrine --- drug effects. --- physiology. --- Agents predominantly affecting the nervous system --- Adrenaline --- Adrenergic mechanisms --- Neuropharmacology --- Sympathomimetic agents --- Pharmacology --- Receptors --- Effect of drugs on --- Textbooks & monographs 1891-2000 --- Textbooks & monographs 1891-2000. --- 615.21 Agents predominantly affecting the nervous system --- Adrenergic activators --- Adrenergic agents --- Adrenomimetics --- Sympathetic transmitter releasers --- Autonomic drugs --- Biomimetics --- Sympathetic nervous system --- Adrenalin --- Bronchodilator agents --- Catecholamines --- Neurotransmitters --- Receptors&delete& --- Congresses --- Effect of drugs on&delete& --- drug effects --- physiology --- Adrenoceptor --- Norepinephrine Receptor --- Receptor, Norepinephrine

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Pharmacology. Therapy --- Adrenergic mechanisms --- Adrenergic receptors --- Radioligand assay --- Receptors, Adrenergic --- Binding sites --- Adrenaline --- Radioligand Assay --- BINDING SITES --- RECEPTORS, ADRENERGIC --- Receptors --- Binding Sites. --- Radioligand Assay. --- Receptors, Adrenergic. --- -Adrenergic mechanisms --- #Lilly --- Binding assay, Radioligand --- Competitive protein binding assay --- Ligand binding assay (Biochemistry) --- Protein binding assay --- Radioreceptor assay --- Receptor binding assay --- Tissue receptor assay --- Analytical biochemistry --- Ligand binding (Biochemistry) --- Protein binding --- Sympathetic nervous system --- Adrenalin --- Epinephrine --- Bronchodilator agents --- Catecholamines --- Neurotransmitters --- Sympathomimetic agents --- Adrenergic Receptor --- Epinephrine Receptors --- Norepinephrine Receptors --- Adrenergic Receptors --- Adrenoceptors --- Receptors, Epinephrine --- Receptors, Norepinephrine --- Receptor, Adrenergic --- Norepinephrine --- Sympathomimetics --- Racepinephrine --- Protein-Binding Radioassay --- Radioreceptor Assay --- Assay, Radioligand --- Assay, Radioreceptor --- Assays, Radioligand --- Assays, Radioreceptor --- Protein Binding Radioassay --- Protein-Binding Radioassays --- Radioassay, Protein-Binding --- Radioassays, Protein-Binding --- Radioligand Assays --- Radioreceptor Assays --- Ligands --- Protein Binding --- Binding Site --- Combining Site --- Combining Sites --- Site, Binding --- Site, Combining --- Sites, Binding --- Sites, Combining --- Protein Interaction Mapping --- Receptors. --- Binding Sites --- Adrenoreceptors --- Adrenoceptor --- Norepinephrine Receptor --- Receptor, Norepinephrine --- Adrenaline - Receptors

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Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotypes, α, β/δ, and γ, which modulate metabolic and inflammatory pathways, making them key for the control of cellular, organ, and systemic processes. PPAR activity is governed by fatty acids and fatty acid derivatives, and by drugs used in clinics (glitazones and fibrates). The study of PPAR action, also modulated by post-translational modifications, has enabled extraordinary advances in the understanding of the multifaceted roles of these receptors in metabolism, energy homeostasis, and inflammation both in health and disease. This Special Issue of IJMS includes a broad range of basic and translational article, both original research and reviews, focused on the latest developments in the regulation of metabolic and/or inflammatory processes by PPARs in all organs and the microbiomes of different vertebrate species.

Research & information: general --- Biology, life sciences --- Biochemistry --- nuclear receptor --- gene transcription --- inflammation --- molecular docking --- PPARβ/δ --- lung --- pulmonary artery --- GW0742 --- GSK3787 --- docking --- lipopolysaccharide (LPS) --- PPARγ ligand --- coumarin --- fluorescent ligand --- screening --- crystal structure --- PPAR --- atopic dermatitis --- psoriasis --- metabolic reprograming --- glucose --- fatty acids --- mycobacteria --- M. tuberculosis --- M. leprae --- PPARs --- lipid droplets --- metabolic alterations --- hepatic damage --- nuclear factors --- pharmacological targets --- AMPK --- GDF15 --- insulin resistance --- type 2 diabetes mellitus --- peroxisome proliferator-activated receptor gamma (PPARγ) --- real-time PCR --- ELISA --- immunohistochemistry --- signaling pathway --- PPAR gamma --- brain --- neural stem cells --- infection --- neuroinflammation --- HIV --- Zika --- cytomegalovirus --- neurogenesis --- microglia --- liver damage --- toll-like receptor 4 --- P2Y2 receptor --- metabolic syndrome --- resveratrol --- quercetin --- PPARα --- peroxisome --- β-oxidation --- PPRE --- ligand --- coregulator --- micronutrients --- PPARα knockout --- adipose tissue --- browning --- lipid metabolism --- depression --- PPARg --- neuropathology --- corticotropin releasing hormone --- norepinephrine --- subgenual prefrontal cortex --- amygdala --- nucleus accumbens --- common carotid artery occlusion --- electroretinography --- fibroblast growth factor 21 --- pemafibrate --- peroxisome proliferator-activated receptor alpha --- retinal ischemia --- skeletal muscle --- substrate metabolism --- nonalcoholic fatty liver disease (NAFLD) --- sex dimorphism --- lipidomics --- hepatic sex-biased gene expression --- PPARγ --- pulmonary arterial hypertension --- TGFβ --- vascular injury --- proliferation --- kidney fibrosis --- pattern-recognition receptors --- phagocytosis --- nitric oxide synthase --- fenofibrate --- oleoylethanolamide --- palmitoylethanolamide --- cancer --- immunity --- obesity --- diabetes --- miRNA --- DNA methylation --- histone modification --- peroxisome-proliferator-activated receptor --- fatty acid oxidation --- doping control --- regulatory T cells --- exercise --- nuclear receptors --- nutrigenomics --- energy homeostasis --- dairy animals --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- peroxisome proliferator-activated receptors (PPAR) --- bezafibrate --- fenofibric acid --- peroxisome proliferator-activated receptor --- dual/pan agonist --- X-ray crystallography --- n/a