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Skin --- Mosaicism. --- Skin Neoplasms. --- Skin Diseases. --- Nevus. --- Diseases.

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Paul Gerson Unna’s “Abtropfung” theory that nevi develop through migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration based on newly acquired observations from histopathology and studies of embryogenesis. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of the aforementioned theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.

Medicine. --- Nevus -- Physiopathology. --- Skin neoplasms -- Physiopathology. --- Mole (Dermatology) --- Skin Diseases --- Neoplasms by Site --- Nevi and Melanomas --- Neoplasms by Histologic Type --- Neoplasms --- Skin and Connective Tissue Diseases --- Diseases --- Skin Neoplasms --- Nevus --- Medicine --- Health & Biological Sciences --- Dermatology --- Skin --- Melanoma. --- Diseases. --- Moles (Dermatology) --- Naevus --- Malignant melanoma --- Melanocytic tumor --- Cutaneous diseases --- Dermatoses --- Dermatology. --- Oncology. --- Medicine & Public Health. --- Cancer --- Neuroendocrine tumors --- Oncology  . --- Tumors

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Highly acclaimed and considered the leading reference in the field, Pathology of Melanocytic Nevi and Melanoma has once again been fully revised, updated, and expanded to reflect the most recent advances and techniques in the field of melanoma pathology. New chapters on mucosal melanoma, ocular melanoma, and pigmented lesions of the nail apparatus have been included in this new edition. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated with the aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, and outstanding characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Pathology of Melanocytic Nevi and Melanoma is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today.

Dermatology. --- Medicine. --- Melanoma -- Pathophysiology. --- Melanoma. --- Oncology. --- Pathology. --- Skin Diseases --- Neoplasms by Site --- Nevi and Melanomas --- Neuroendocrine Tumors --- Epithelial Cells --- Neoplasms by Histologic Type --- Neuroectodermal Tumors --- Cells --- Neoplasms --- Skin and Connective Tissue Diseases --- Diseases --- Anatomy --- Neoplasms, Nerve Tissue --- Neoplasms, Germ Cell and Embryonal --- Skin Neoplasms --- Melanoma --- Melanocytes --- Nevus --- Medicine --- Health & Biological Sciences --- Oncology --- Pathophysiology. --- Malignant melanoma --- Melanocytic tumor --- Medicine & Public Health. --- Cancer --- Neuroendocrine tumors --- Oncology  . --- Tumors --- Skin --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive

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This book includes a collection of publications describing the molecular etiology of inherited diseases and conditions in companion animals (dogs and cats). In addition to contributing to the health of companion animals, this research also benefits humans that have similar types of diseases.

Research & information: general --- Biology, life sciences --- Canis familiaris --- dermatology --- immunology --- animal model --- skin --- TLR7 --- toll-like receptor --- syndecan binding protein --- syntenin-1 --- systemic lupus erythematosus --- SLE --- CLE --- whole-genome sequencing --- craniomandibular osteopathy --- calvarial hyperostotic syndrome --- Caffey disease --- infantile cortical hyperostosis --- rare disease --- SLC37A2 --- COL1A1 --- SLC35D1 --- Canis lupus familiaris --- whole-genome sequence --- genodermatosis --- keratinocyte --- SAM syndrome --- precision medicine --- dog --- desmosome --- acantholysis --- calcium --- veterinary medicine --- feline --- Felis catus --- brain malformation --- BMP12 --- neurodevelopment --- genetics --- genomics --- mendelian traits --- genome-wide association study --- whole genome sequencing --- mitochondrion --- phosphoenolpyruvate-carboxykinase --- inborn error of metabolism --- encephalopathy --- SSADHD --- ALDH5A1 --- GABA --- 4-hydroxybutyric acid --- succinic semialdehyde --- GWAS --- inherited --- whole genome sequence --- wgs --- laminin --- Bardet–Biedl syndrome (BBS) --- primary cilia --- ciliopathy --- BBS8 --- progressive retinal atrophy (PRA) --- retinitis pigmentosa --- canine --- dystrophinopathy --- Duchenne --- immunohistochemistry --- neurometabolic disorder --- CHILD syndrome --- ILVEN --- epidermal nevus --- diabetes mellitus --- Burmese cats --- susceptibility --- single-nucleotide polymorphism --- genetic markers --- LIPH --- obesity --- companion animals --- metabolic disease --- comparative genomics --- dogs --- cats --- horses --- contactin --- neurological disorder --- Leonberger --- Saint Bernard --- Labrador retriever --- n/a --- Bardet-Biedl syndrome (BBS)