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An in-depth look at a rare disease Myasthenia gravis (MG) is a rare autoimmune disorder of the neuromuscular junction, characterized by muscle fatigability. Patients often initially present with ocular symptoms, but in most cases the disease spreads beyond the eye muscles to more generalized involvement of bulbar, facial, neck, proximal limb and respiratory muscles. With adequate treatment, most patients with MG are able to live productive lives with few or no symptoms, but a distinct subset of patients do not respond to conventional treatment. With new treatment options on the horizon, it is important that these patients are identified. 'Fast Facts: Recognizing Refractory Myasthenia Gravis' takes an in-depth look at: • the immune-mediated nature of MG • classification of MG by disease type and severity, and antibody status • clinical presentation and diagnostic work-up • conventional management options • how patients with treatment-refractory MG present • the assessment tools that can be used to identify non-responders. This informative resource will be of value to neurologists, neurology trainees and ophthalmologists caring for patients with this rare disease, as well as patients with MG who wish to have a deeper dialog with their doctor or patient group. Contents: • Definition and epidemiology • Pathophysiology and classification • Diagnosis and management: an overview • Assessment of disease severity and treatment response

Myasthenia gravis --- Diagnosis. --- Neuromuscular diseases

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Advances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common resource for understanding this complex disorder. This new edition begins with discussions of neuromuscular junction structure and function and follows with updated chapters covering a wide range of topics, such as the acetylcholine receptor, clinical presentation, diagnostic evaluation, and treatment. Importantly, new supplemental chapters have been added; these discuss rigorous clinical assessments of patients for research trials and the epidemiology and genetics of myasthenia gravis. The discussion of the most challenging aspects of myasthenia gravis, its impact on patients’ psychological make-up, has been expanded as well. Myasthenia Gravis and Related Disorders, Second Edition retains the "personal approach" of the authors regarding treatment and is a valuable resource for meeting the many and varied needs of patients with myasthenia gravis.

Myasthenia gravis. --- Myoneural junction. --- Neuromuscular diseases. --- Myasthenia gravis --- Neuromuscular diseases --- Myoneural junction --- Myasthenia Gravis --- Diagnosis --- Neuromuscular Junction Diseases --- Autoimmune Diseases of the Nervous System --- Neuromuscular Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Autoimmune Diseases --- Nervous System Diseases --- Diseases --- Immune System Diseases --- Neurology --- Medicine --- Health & Biological Sciences --- Pathophysiology. --- Neuromotor disorders --- Neuromuscular disorders --- Motor end plate --- Neuromuscular end plate --- Neuromuscular junction --- Medicine. --- Immunology. --- Neurosciences. --- Neurology. --- Ophthalmology. --- Medicine & Public Health. --- Muscles --- Nervous system --- Nerve endings --- Nerves

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The third edition of this important, gold-standard title outlines a range of significant advances in the study and understanding of myasthenia gravis. The overarching goal of this new edition is identical to the first and second -- to provide the clinician and the scientist with a common resource for understanding the profound achievements in the clinical, translational, and basic sciences of neuromuscular transmission disorders. In addition to several new authors and an extensive update of all chapters, this third edition includes summaries of pre-clinical research standards for autoimmune MG, along with a broad summary of MG clinical trial performance. The now greater understanding of the clinical presentation of MuSK-related MG and identification of potential new autoantigens, including LRP-4, is discussed. The development of treatment guidelines by groups in Japan, the United Kingdom, Germany, and an international consortium is also outlined. Myasthenia Gravis and Related Disorders, Third Edition, is an invaluable resource for meeting the many and varied needs of clinicians who treat patients with myasthenia gravis.

Myasthenia gravis --- Myoneural junction. --- Pathophysiology. --- Medicine. --- Immunology. --- Neurosciences. --- Respiratory organs --- Neurology. --- Medicine & Public Health. --- Pneumology/Respiratory System. --- Diseases. --- Medicine --- Nervous system --- Neuropsychiatry --- Respiratory diseases --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Diseases --- Motor end plate --- Neuromuscular end plate --- Neuromuscular junction --- Muscles --- Nerve endings --- Nerves --- Neuromuscular diseases --- Pneumology. --- Neurology . --- Respiratory organs—Diseases. --- Neuroscience.