Listing 1 - 2 of 2 |
Sort by
|
Choose an application
The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.
STRIPAK --- skin cancer --- n/a --- Lats2 --- transcription --- myofibroblast --- epigenetic --- Hippo --- cancer immunity --- TAZ --- Taz --- TAZ (transcriptional co-activator with PDZ-binding motif) --- adaptive immunity --- fibroblasts --- innate immunity --- LATS --- MST (mammalian STE20-like protein kinase) --- phosphorylation --- stem cells --- wound healing --- signal transduction --- angiogenesis --- LATS1/2 --- EMT --- protein-protein interactions --- structure biology --- Hippo pathway --- hippo pathway --- autoimmunity --- Mps one binder --- YAP/TAZ --- GPCR --- fibrosis --- MST1/2 --- YAP (yes-associated protein) --- YAP --- Yap --- protein kinase --- LATS (large tumor suppressor kinase) --- peripheral nerve sheath tumor --- signal cross-talk --- stem cell --- skin development --- STK38 --- tumorigenesis --- NDR --- schwannoma --- G protein-coupled receptor --- anti-cancer therapy --- feedback loops --- vascular mimicry --- castration resistance --- chromatin --- Hippo signalling --- ECM --- MST --- prostate cancer --- TEAD --- cancer --- zebrafish
Choose an application
The authors of this volume concentrate on the recent progress of novel polyoxometalate (POM) syntheses, as well as advances made in catalytic, electrochemical, and sensing systems. The state-of-the-art techniques such as flow system and gel-electrophoresis for the discovery of POMs are covered with a detailed discussion. Of particular importance, the application of POM-based materials in photo-sensing, heterogeneous catalysis, energy conservation and storage, and gas separation is reviewed. Over the past few years, POM chemistry has witnessed a remarkable progress with more than 1500 papers published each year. Due to their intrinsic structural features, POMs are considered as versatile building blocks for the construction of sophisticated complex assemblies and advanced multi-functional materials. Various strategies, methods, and techniques have been adopted to develop POM-based materials with intriguing properties and excellent performance. All the contributors to this volume are young, vibrant chemists in this research field and all the works are carefully collected from the authors’ years of experience. This volume serves as an essential reference for every POM chemist and is of great interest to new researchers who wish to learn more about this area.
Chemistry. --- Inorganic chemistry. --- Organometallic chemistry. --- Physical chemistry. --- Physical Chemistry. --- Organometallic Chemistry. --- Inorganic Chemistry. --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Chemistry --- Chemistry, Organometallic --- Metallo-organic chemistry --- Chemistry, Organic --- Inorganic chemistry --- Inorganic compounds --- Physical sciences --- Chemistry, Physical organic. --- Chemistry, Organic. --- Chemistry, inorganic. --- Organic chemistry --- Chemistry, Physical organic --- Chemistry, Physical and theoretical --- Polioxometal·lats. --- Materials. --- Physical organic chemistry. --- Engineering --- Engineering materials --- Industrial materials --- Engineering design --- Manufacturing processes --- Materials --- Organometallic chemistry .
Listing 1 - 2 of 2 |
Sort by
|