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Guanosine triphosphatase --- Guanosine triphosphatase. --- GTP phosphohydrolase --- GTPase --- Guanosine triphosphate phosphohydrolase --- Guanosinetriphosphatase --- Phosphatases --- Health Sciences --- Physiology --- Animal Biochemistry --- GTPases

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For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.

Guanosine triphosphatase. --- GTPase-activating protein. --- ADP-ribosylation. --- Biochemistry. --- Evolution (Biology). --- Biochemistry, general. --- Evolutionary Biology. --- Evolutionary biology. --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Cellular signal transduction --- GAP (Protein) --- Proteins --- GTP phosphohydrolase --- GTPase --- Guanosine triphosphate phosphohydrolase --- Guanosinetriphosphatase --- Phosphatases

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Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.

Guanosine triphosphatase. --- Protein binding. --- Chemistry --- Human Anatomy & Physiology --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Organic Chemistry --- Animal Biochemistry --- G proteins --- Guanosine triphosphatase --- Biological transport. --- Physiological transport. --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- GTP phosphohydrolase --- GTPase --- Guanosine triphosphate phosphohydrolase --- Guanosinetriphosphatase --- Chemistry. --- Analytical chemistry. --- Bioorganic chemistry. --- Biochemistry. --- Proteomics. --- Bioorganic Chemistry. --- Analytical Chemistry. --- Biochemistry, general. --- Molecular biology --- Proteins --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Analysis, Chemical --- Analytical chemistry --- Chemical analysis --- Metallurgical analysis --- Mineralogy, Determinative --- Physical sciences --- Composition --- Diffusion --- Osmosis --- Phosphatases --- Membrane proteins --- Analytical biochemistry. --- Analytic biochemistry --- Chemistry, Analytic --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytic chemistry