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The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

Molecular biology --- Oncology. Neoplasms --- moleculaire biologie --- kwaadaardige gezwellen --- Cancer --- Cancer cells. --- Cellules cancéreuses --- Molecular aspects. --- Genetic aspects. --- Aspect moléculaire --- Aspect génétique --- Cancer cells --- Neoplasms --- Genes, Neoplasm --- Cell Transformation, Neoplastic --- Molecular aspects --- Genetic aspects --- genetics --- Cell Transformation, Neoplastic. --- Genes, Neoplasm. --- genetics. --- Genetics. --- Cellules cancéreuses --- Aspect moléculaire --- Aspect génétique --- Monograph --- Cancer - Molecular aspects --- Cancer - Genetic aspects --- Neoplasms - genetics

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Bioinformatic integration of the findings from recent genomic and proteomic research has made possible the development of highly selective therapeutics that can target specific cellular pathways controlling cell proliferation, differentiation, metastasis, evasion of immune surveillance, angiogenesis, and apoptosis. In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including rituximab, Herceptin®, Avastin™, ABGX-EGF, Velcade®, Iressa®, and Zevalin® are addressed. Additional chapters review clinical diagnostics, bioanalytics, and biomarkers and their importance to therapeutic outcome; detail antiangiogenic, supportive, immunomodulatory, and tumor-targeted approaches to cancer therapy; and provide a systems biology-bioinformatics overview of strategies and initiatives for the postgenomic era. Highlights include cancer genomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation. Authoritative and state-of-the-art, The Oncogenomics Handbook offers cancer researchers and drug developers a comprehensive update on the contribution of the genomic revolution to cancer drug discovery and development.

Cancer --- Oncogenes --- Genomics --- Proteomics --- Oncogènes --- Génomique --- Protéomique --- Genetic aspects --- Handbooks, manuals, etc. --- Aspect génétique --- Guides, manuels, etc. --- Cancer -- Genetic aspects -- Handbooks, manuals, etc. --- Genomics -- Handbooks, manuals, etc. --- Oncogenes -- Handbooks, manuals, etc. --- Proteomics -- Handbooks, manuals, etc. --- Genes, Neoplasm --- Diseases --- Biology --- Computational Biology --- Genes --- Biological Science Disciplines --- Genome Components --- Natural Science Disciplines --- Disciplines and Occupations --- Genome --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Genetics --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Genome research --- Genomes --- Onc genes --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Research --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Molecular biology --- Proteins --- Molecular genetics --- Cancer genes --- Proto-oncogenes --- Oncology  .

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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Cancer -- Genetic aspects. --- Cancer genes. --- Gene expression. --- Gene expression --- Cancer genes --- Cancer --- Genetic Techniques --- Biology --- Genes --- Biological Science Disciplines --- Genome Components --- Investigative Techniques --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genome --- Genetic Structures --- Disciplines and Occupations --- Genetic Phenomena --- Phenomena and Processes --- Genetics --- Genes, Neoplasm --- Gene Expression Profiling --- Medicine --- Health & Biological Sciences --- Pathology --- Oncology --- Genetic aspects --- Gene therapy. --- Therapy, Gene --- Expression --- Medicine. --- Laboratory medicine. --- Oncology. --- Pathology. --- Medicine & Public Health. --- Laboratory Medicine. --- Genetic engineering --- Therapeutics --- Genetic regulation --- Oncology  . --- Medical laboratories. --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis

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Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal its unique structural features and biochemical functions. In p53 Protocols, Sumitra and Swati Palit Deb have assembled an indispensable collection of novel techniques that have proven most useful for studying the physiological properties of p53 both in vitro and in vivo. Described by leading basic and clinical researchers who have successfully used the methods, the techniques provide proven solutions to problems in studying the purification, target identification, gene expression, quantitation, interaction, signaling, transactivation, and transrepression of p53. The methods are also useful for delineating the functions of other proteins that may act as tumor or growth suppressors. Each technique includes step-by-step instructions, troubleshooting notes, a theoretical review, and discussion of associated problems that might arise during the course of investigation. Special effort has been made to discuss problems and their solutions to help ease the learning curve when standardizing a new method. Diverse and highly practical, p53 Protocols offers both beginning and experienced researchers in cancer biology a gold-standard compendium of readily reproducible techniques for studying p53 and related proteins.

Protein p53 --- Tumor Suppressor Proteins --- Genes, p53 --- Neoplasms --- p53 protein --- p53 antioncogene --- Protéine p53 --- Gène p53 --- analysis --- therapeutic use --- physiology --- genetics --- Laboratory manuals --- Manuels de laboratoire --- Electronic books. -- local. --- p53 antioncogene -- Laboratory manuals. --- p53 protein -- Laboratory manuals. --- Tumor Suppressor Protein p53 --- Genetics --- Physiology --- Biological Science Disciplines --- Phosphoproteins --- DNA-Binding Proteins --- Biology --- Genes, Tumor Suppressor --- Nuclear Proteins --- Neoplasm Proteins --- Diseases --- Proteins --- Genes, Recessive --- Natural Science Disciplines --- Genes, Neoplasm --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Genes --- Chemicals and Drugs --- Genome Components --- Genome --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Animal Biochemistry --- Cytology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Protéine p53 --- Gène p53 --- p53 gene --- p53 suppressor gene --- Antioncogenes --- Protein TP53 --- TP53 protein --- DNA-binding proteins --- Tumor suppressor proteins --- analysis. --- physiology. --- genetics. --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Cells --- Cytologists

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The initial identification of the Adenomatous polyposis coli (Apc) gene as the site of mutations in familial adenomatous polyposis (FA P) was described in 1992. A causal relationship between Apc mutations and intestinal tract tumours was confirmed three years later with the establishment of the Min mouse model. These mice are heterozygous for Apc and develop numerous intestinal tumours that mimic FA P. Subsequently, Apc has emerged as the most commonly mutated gene in colorectal cancer with reports varying between 50-80 per cent of sporadic tumours carrying such mutations. The search for how m

Adenomatous Polyposis Coli Protein. --- Adenomatous Polyposis Coli. --- Colon (Anatomy) -- Cancer. --- Colorectal Neoplasms -- Metabolism. --- Genes, APC. --- Tumor suppressor proteins. --- Colon (Anatomy) --- Tumor suppressor proteins --- Adenomatous Polyposis Coli --- Colorectal Neoplasms --- Genes, APC --- Metabolism --- Adenomatous Polyposis Coli Protein --- Intestinal Polyposis --- Intestinal Neoplasms --- Colonic Neoplasms --- Neoplastic Syndromes, Hereditary --- Colonic Diseases --- Metabolic Phenomena --- Cytoskeletal Proteins --- Genes, Tumor Suppressor --- Tumor Suppressor Proteins --- Rectal Diseases --- Adenomatous Polyps --- Proteins --- Neoplasm Proteins --- Intestinal Diseases --- Neoplasms --- Genes, Neoplasm --- Phenomena and Processes --- Gastrointestinal Neoplasms --- Genes, Recessive --- Adenoma --- Genetic Diseases, Inborn --- Gastrointestinal Diseases --- Digestive System Neoplasms --- Genes --- Diseases --- Neoplasms, Glandular and Epithelial --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Digestive System Diseases --- Genome Components --- Neoplasms by Site --- Neoplasms by Histologic Type --- Genome --- Genetic Structures --- Genetic Phenomena --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Cancer. --- Antioncoproteins --- Growth suppressor proteins --- Metastasis suppressor proteins --- Colon cancer --- Colorectal cancer --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antioncogenes --- Health Workforce --- Biomedicine, general.