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Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms. Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
Infertility, Male --- Spermatogenesis --- Genetic aspects --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Formation --- Diseases
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Embryology --- Gametogenesis --- Developmental biology --- Morphogenesis --- Embryologie --- Gamétogenèse --- Biologie du développement --- Morphogénèse --- Gamétogenèse --- Biologie du développement --- Morphogénèse
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Spermatogenesis --- Cellular control mechanisms --- Cellular control mechanisms. --- Genetic aspects --- Genetic aspects. --- Genetics --- Cell regulation --- Biological control systems --- Cell metabolism --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation --- Spermatogenesis. --- Spermatocytogenesis --- Spermiogenesis
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Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine. Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest. "This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm." Pawan K. Singal St. Boniface General Hospital Research Center .
Spermatogenesis. --- Proteomics. --- Molecular biology --- Proteins --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology. --- Proteins. --- Protein Biochemistry. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics
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Developmental biology --- Embryology --- Biologie du développement --- Embryologie --- Developmental Biology --- Biologie du développement. --- Embryologie. --- Biologie du développement --- Monograph --- Gametogenesis --- Biological development --- Morphogenesis --- Fecundation --- Embryonic development --- Organogenesis --- Animals --- Development --- Cleavage stage, Ovum --- Cell differentiation --- Fertility --- Cells --- Cell recognition --- Interactions --- Genetics
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Biologie [Ontwikkelings] --- Biologie du développement --- Development (Biology) --- Développement [Biologie du ] --- Ontwikkelingsbiologie --- Gamétogénèse --- Spermatogénèse --- Oviposition --- Fécondation --- Développement embryonnaire --- Embryonic development --- Morphogénèse --- Embryology --- Developmental Biology. --- Developmental biology --- Biologie du développement --- Embryologie --- animals --- Gametogenesis --- Spermatogenesis --- Fertilization --- Morphogenesis --- Embryology.
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Comment le spermatozoïde et l'œuf interagissent-ils pour former un nouvel organisme? Comment une seule cellule donne-t-elle naissance à tous les types cellulaires d'un organisme adulte? Comment les neurones arrivent-t-ils à établir leurs connexions avec les autres neurones et les tissus périphériques? Comment se forment les organes? Autant de questions qui montrent le rôle éminent de la biologie du développement car elle intègre toutes les facettes de la biologie et joue le rôle crucial d'établir une relation entre génotype et phénotype. On peut étudier ainsi le développement à partir de n'importe quel organisme et à n'importe quel niveau d'organisation, de la molécule à l'espèce. La nouvelle édition de Biologie du développement a été profondément remaniée pour intégrer les acquis de la révolution génétique. Elle comporte notamment trois chapitres d'introduction qui exposent les données de base sur l'analyse génétique et sur les membranes cellulaires. les chapitres consacrés à la génétique du développement précèdent ceux qui examinent la spécification des axes de l'organisme et la détermination des premiers types cellulaires. En outre, pour respecter les approches biologiques et moléculaires, certaines frontières séparant la biologie du développement et ses disciplines connexes, comme la biologie de l'évolution et la génétique, ont été abolies.
Biologie --- Developmental Biology --- Embryology --- Developmental biology --- Biologie du développement --- Embryologie --- ontwikkelingsbiologie --- biologie du développement --- Biologie du développement --- Developmental Biology. --- Embryology. --- Gametogenesis --- Biological development --- Morphogenesis --- Fecundation --- Embryonic development --- Organogenesis --- Animals --- Development --- Cleavage stage, Ovum --- Cell differentiation --- Fertility --- Cells --- Cell recognition --- Genetics --- Interactions
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Advances in technology now offer promising solutions to deal with the chronological aging of the cell, tissue or organ to synchronize its existence and its use. This book covers the developments in and benefits of the latest vitrification technology and its extensive applications in reproductive medicine. Protocols of gametes (oocyte and sperm), embryos, blastocysts and ovarian tissue cryopreservation have been reviewed by leaders in the field. In order to address the escalation in cross-border reproductive tourism entailing the transfer of reproductive cells and tissues rather than the patient, the challenges, caution and emerging possibilities of nitrogen vapor shipment of vitrified cells have been discussed. Current perspectives on oocyte banking present the reader with options and solutions to effectively utilize these gametes despite the physiological deterrants.The versatile applications and potential of vitrification of human embryonic stem cells, discussed in the concluding chapter, is an exciting reality offered by vitrification to help overcome numerous stumbling blocks in the management of various disorders. .
Medicine & Public Health. --- Reproductive Medicine. --- Gynecology. --- Obstetrics/Perinatology. --- Medicine. --- Obstetrics. --- Médecine --- Gynécologie --- Obstétrique --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Reproductive technology. --- Gametogenesis. --- Assisted reproduction --- Reproduction --- Formation of gametes --- Gametes --- Technological innovations --- Formation --- Reproductive medicine. --- Biotechnology --- Cell differentiation --- Obstetrics/Perinatology/Midwifery. --- Gynaecology --- Generative organs, Female --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Maternal-fetal medicine --- Diseases --- Health aspects --- Gynecology .
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Fertilization (Biology) --- Spermatogenesis --- Spermatozoa --- Testis --- Congresses --- physiology --- 591.463.1 --- -Spermatogenesis --- -Spermatozoa --- -Testis --- -Testes --- Testicle --- Endocrine glands --- Generative organs, Male --- Gonads --- Scrotum --- Male gametes --- Sperm --- Gametes --- Semen --- Formation of spermatozoa --- Gametogenesis --- Amphimixis --- Biology --- Cells --- Embryology --- Physiology --- Reproduction --- physiology. --- Sperm. Spermatogenesis --- Formation --- Congresses. --- -physiology. --- 591.463.1 Sperm. Spermatogenesis --- -591.463.1 Sperm. Spermatogenesis --- Testes
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This book is focused on Sertoli cell physiology and its role in the spermatogenic event. These cells, known as “nurse cells”, are essential for the normal development of germ cells by offering not only physical support and creating an immune-privileged environment, but also for providing nutritional support. The presence of Sertoli cells promotes the establishment of the appropriate microenvironment so that spermatogenesis may occur. Spermatogenesis maintenance in vivo is highly dependent on the metabolic cooperation established between Sertoli cells and developing germ cells. For many years this metabolic cooperation between testicular cells has been disregarded, but recent advances have highlighted the relevance of these processes for male fertility. Thus, the understanding of the functioning and regulation of these metabolic processes is a crucial step to identify key mechanisms associated with Sertoli cell (dys)function and to enlighten their influence on male fertility.
Medicine. --- Cell culture. --- Biomedicine. --- Biomedicine general. --- Cell Culture. --- Spermatogenesis. --- Sertoli cells --- Metabolism. --- Cells of Sertoli --- Sertoli's cells --- Sustentacular cells --- Formation of spermatozoa --- Spermatozoa --- Formation --- Cells --- Testis --- Gametogenesis --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cultures (Biology) --- Cytology --- Technique --- Health Workforce --- Biomedicine, general.
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