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Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impac
Eukaryotic Cells. --- Gene Expression Regulation. --- Transcription Factors. --- Transcription, Genetic. --- Transcription factors. --- Genetic transcription --- Eukaryotic cells. --- Facteurs de transcription --- Transcription génétique --- Cellules eucaryotes --- Regulation. --- Régulation --- Genetic transcription. --- Genetic regulation --- Genetic transcription factors --- Proteins --- Transcription factors --- Eukaryotic cells --- MOLECULAR STRUCTURE --- BASE SEQUENCE --- DNA-BINDING PROTEINS --- GENETIC PREDISPOSITION TO DISEASE --- TRANSCRIPTION, GENETIC --- DNA-DIRECTED RNA POLYMERASES --- CHROMATIN --- TRANSCRIPTION FACTORS --- ULTRASTRUCTURE
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Biological techniques --- Enzymology --- Molecular biology --- Gene amplification --- Polymerase chain reaction --- DNA-Directed DNA Polymerase --- Gene Amplification --- Molecular Biology --- DNA-Directed RNA Polymerases --- DNA-Directed DNA Polymerase. --- Gene Amplification. --- Molecular Biology. --- DNA-Directed RNA Polymerases. --- Chain reaction, Polymerase --- PCR (Biochemistry) --- Polymerization --- DNA polymerases --- Amplification, Gene --- Gene expression --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Gene amplification. --- Polymerase chain reaction. --- DNA Polymerases. --- Genetic Engineering. --- Molecular biology. --- RNA Polymerases. --- Genetic Phenomena --- Dna polymerases. --- Genetic engineering. --- Rna polymerases. --- Genetic Engineering --- DNA --- ADN polymérases --- ADN --- Synthesis --- Biotechnology --- Synthèse --- Biotechnologie --- DNA-Directed RNA Polymerase --- RNA Polymerase --- Transcriptase --- DNA-Dependent RNA Polymerases --- RNA Polymerases --- Transcriptases --- DNA Dependent RNA Polymerases --- DNA Directed RNA Polymerase --- DNA Directed RNA Polymerases --- Polymerase, DNA-Directed RNA --- Polymerase, RNA --- Polymerases, DNA-Dependent RNA --- Polymerases, DNA-Directed RNA --- Polymerases, RNA --- RNA Polymerase, DNA-Directed --- RNA Polymerases, DNA-Dependent --- RNA Polymerases, DNA-Directed --- DNA Polymerase N3 --- DNA Polymerases --- DNA-Dependent DNA Polymerases --- DNA Dependent DNA Polymerases --- DNA Directed DNA Polymerase --- DNA Polymerase, DNA-Directed --- DNA Polymerases, DNA-Dependent --- Polymerase N3, DNA --- Polymerase, DNA-Directed DNA --- Polymerases, DNA --- Polymerases, DNA-Dependent DNA --- DNA Polymerase --- Polymerase, DNA --- Dna polymerases --- Rna polymerases
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The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel ‘protein occupancy profiling’ technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3’ UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universität Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany. .
Engineering. --- Biomedical Engineering. --- Systems Biology. --- Computational Biology/Bioinformatics. --- Bioinformatics. --- Biological models. --- Biomedical engineering. --- Ingénierie --- Bio-informatique --- Modèles biologiques --- Génie biomédical --- Health & Biological Sciences --- Biomedical Engineering --- RNA-protein interactions. --- RNA polymerases. --- DNA-dependent RNA polymerases --- DNA-directed RNA polymerases --- Polymerases, RNA --- Ribonucleate nucleotidyltransferases --- RNA nucleotidyltransferases --- Interactions, RNA-protein --- Protein-RNA interactions --- RNA-protein binding --- Systems biology. --- Protein binding --- Transferases --- Biomedical Engineering and Bioengineering. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Models, Biological --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Data processing --- Bioinformatics --- Biological systems --- Molecular biology
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Molecular biology --- Analytical biochemistry --- DNA Polymerases --- Gene Amplification --- Genetic Engineering --- RNA Polymerases --- Polymerase chain reaction --- Gene amplification --- Réaction en chaîne de la polymérase --- Redondance génétique --- methods --- DNA-Directed RNA Polymerases --- Biologie moléculaire --- Enzymes --- Clonage moléculaire --- molecular cloning --- Virologie --- Virology --- Virus --- viruses --- Identification --- identification --- ADN --- DNA --- ARN --- RNA --- Génétique --- genetics --- Évolution --- evolution --- Expérimentation en laboratoire --- Laboratory experimentation --- Méthodologie --- methodology --- DNA-Directed DNA Polymerase. --- Nucleic Acid Amplification Techniques. --- DNA-Directed RNA Polymerases. --- 577.212.3 --- 57.088.1 --- Chain reaction, Polymerase --- PCR (Biochemistry) --- Polymerization --- DNA polymerases --- Amplification, Gene --- Gene expression --- Amplification Technics, Nucleic Acid --- Amplification Techniques, Nucleic Acid --- DNA Amplification Technics --- Nucleic Acid Amplification Technics --- Nucleic Acid Amplification Test --- Nucleic Acid Amplification Tests --- RNA Amplification Technics --- Technics, Nucleic Acid Amplification --- Techniques, Nucleic Acid Amplification --- DNA Amplification Techniques --- RNA Amplification Techniques --- Amplification Technic, DNA --- Amplification Technic, RNA --- Amplification Technics, DNA --- Amplification Technics, RNA --- Amplification Technique, DNA --- Amplification Technique, RNA --- Amplification Techniques, DNA --- Amplification Techniques, RNA --- DNA Amplification Technic --- DNA Amplification Technique --- RNA Amplification Technic --- RNA Amplification Technique --- Technic, DNA Amplification --- Technic, RNA Amplification --- Technics, DNA Amplification --- Technics, RNA Amplification --- Technique, DNA Amplification --- Technique, RNA Amplification --- Techniques, DNA Amplification --- Techniques, RNA Amplification --- methods. --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Methods for analysis and estimation --- Polymerase chain reaction. --- Gene amplification. --- DNA Polymerases. --- RNA Polymerases. --- 57.088.1 Methods for analysis and estimation --- 577.212.3 Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Dna polymerases. --- Genetic engineering --- Rna polymerases. --- Methods. --- Réaction en chaîne de la polymérase --- Redondance génétique --- DNA-Directed DNA Polymerase --- Nucleic Acid Amplification Techniques --- DNA-Directed RNA Polymerase --- RNA Polymerase --- Transcriptase --- DNA-Dependent RNA Polymerases --- Transcriptases --- DNA Dependent RNA Polymerases --- DNA Directed RNA Polymerase --- DNA Directed RNA Polymerases --- Polymerase, DNA-Directed RNA --- Polymerase, RNA --- Polymerases, DNA-Dependent RNA --- Polymerases, DNA-Directed RNA --- Polymerases, RNA --- RNA Polymerase, DNA-Directed --- RNA Polymerases, DNA-Dependent --- RNA Polymerases, DNA-Directed --- DNA Polymerase N3 --- DNA-Dependent DNA Polymerases --- DNA Dependent DNA Polymerases --- DNA Directed DNA Polymerase --- DNA Polymerase, DNA-Directed --- DNA Polymerases, DNA-Dependent --- Polymerase N3, DNA --- Polymerase, DNA-Directed DNA --- Polymerases, DNA --- Polymerases, DNA-Dependent DNA --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code --- viruses. --- identification. --- DNA. --- RNA. --- evolution. --- Nucleic Acid Amplification Technic --- Nucleic Acid Amplification Technique --- DNA Polymerase --- Polymerase, DNA --- Gene Amplification - methods --- Genetic Engineering - methods --- Polymerases --- Rna --- DNA POLYMERASES --- GENE AMPLIFICATION --- GENETIC ENGINEERING --- RNA POLYMERASES --- METHODS
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