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The fatigue behavior of traditional and advanced materials is a very relevant topic in different strategic applications impacting and affecting our daily lives. The present Special Issue invites papers to update readers on the state of the art on this important topic. Both review and original manuscripts are welcome. Special attention will be dedicated to innovative materials and innovative manufacturing processes or post-treatments able to improve the fatigue life and reliability of a structural component. Scale effect will be also fully treated focusing on different applications and multiscale approaches aimed at understanding structural integrity under cyclic loadings. This state of the art perspective will help engineers, designers and people from the academy gain an updated view on this very challenging topic which is nowadays very important due to the advances in manufacturing technologies that allow complex new materials to be fabricated.

History of engineering & technology --- elevated temperature --- low cycle fatigue --- damage accumulation --- uniaxial and multiaxial loading --- precipitates --- fatigue crack growth --- creep aging --- artificial aging --- fatigue --- nickel-based single crystal superalloy --- life modeling --- resolved shear stress --- railway axle --- semi-elliptical crack --- residual stresses --- friction stir welding --- residual stress --- weak area --- finite element simulation --- life prediction --- high temperature --- 12Cr1MoV steel --- mixed salt environments --- corrosion fatigue --- heat pipe failure --- critical plane model --- multiaxial fatigue --- non–proportional loading --- 316 stainless steel --- 304 stainless steel --- fracture toughness --- coarse-grained heat affected zone (CGHAZ) --- X80 pipeline steels --- weld thermal simulation --- finite element analysis (FEA) --- fatigue performance --- rounded welding region --- finite element modeling (FEM) --- structure optimization --- reinforcing plate --- isotropic hardening --- crack tip opening displacement --- CTOD --- crack closure --- metal matrix composites --- powder metallurgy --- Fe/B4C composites --- iron boride phases (Fe2B/FeB) --- Charpy impact test --- single crystal superalloy --- recrystallization --- fatigue small crack --- slip --- in situ SEM --- ultrasonic cyclic testing --- frequency effect --- control type effect --- strain rate effect --- 50CrMo4 --- SAE 4150 --- high cycle fatigue --- very high cycle fatigue --- statistical analyses --- n/a --- non-proportional loading