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This chapter summarised current knowledge on thymic senescence, a central immune tissue that suffers significant morphological changes and functional impairment during ageing. The epithelial network is in focus that provides the niche for developing thymocytes until adipose involution begins. We have discussed physiological thymic epithelial senescence in detail with respect to the signalling pathways involved in the process (Kvell et al. 2010). It has also been shown that steroid induced accelerated rate thymic epithelial senescence quite resembles physiological rate senescence (except for its speed) at the molecular level (Talaber et al. 2011). The data presented confirm that Wnt4 can efficiently rescue thymic epithelial cells from steroid-induced adipose involution at the molecular level (Talaber et al. 2011). Since physiological and steroid-induced thymic epithelial senescence are identical at the molecular level, it is anticipated that sustained Wnt4 presence in the thymic context can efficiently prolong FoxN1 expression, maintain thymic epithelial identity and prevent transdifferentiation towards adipocyte lineage. The same works identify LAP2[alpha] as a pro-ageing molecular factor promoting the trans-differentiation of thymic epithelial cells into preadipocytes via EMT. The thymus selective decrease of LAP2[alpha] activity through small molecule compounds could theoretically shift the delicate molecular balance towards the same direction as increased Wnt4 presence.

Cellular signal transduction. --- Cellular signal transduction --- Research.

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Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential drug targets. Elucidating the dynamic behavior of the components of pathways, and their interactions, is one of the key research areas of systems biology. Biological signaling networks are characterized by a large number of components and an even larger number of parameters describing the network. Furthermore, investigations of signaling networks are characterized by large uncertainties of the network as well as limited availability of data due to expensive and time-consuming experiments. As such, techniques derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter estimation, are important tools for elucidating the mechanisms involved in signaling networks. This Special Issue contains papers that investigate a variety of different signaling networks via established, as well as newly developed modeling and analysis techniques.

Cellular signal transduction.

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Plant cellular signal transduction --- Transduction du signal cellulaire chez les plantes --- Plant cellular signal transduction.

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The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field):* Initiation: Extracellular and Membrane Events* Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation* Events in Intracellular Compartment

Histology. Cytology --- General biochemistry --- Cell interaction. --- Cellular signal transduction. --- Cellular signal transduction. Cell interaction. --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Cellular signal transduction --- Cell interaction

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Cell receptors --- Ligands (Biochemistry) --- Cellular signal transduction --- Receptors, Cell Surface. --- Ligands. --- Signal Transduction. --- Cell receptors. --- Cellular signal transduction. --- Biophysics --- Ligands (Biochimie) --- Transduction du signal cellulaire