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Coronaviruses are the RNA viruses with the largest genome known to date (27 to 32 kb). Members of this virus family affect most domestic animal species, causing important socio-economical losses, and also infect humans. Human coronaviruses were known to cause the winter common cold, a mild infection without important pathological consequences except in immuno-compromised patients. Recently, two new human coronaviruses have emerged, one causing the Severe and Acute Respiratory Syndrome (SARS) that infected more than 8000 individuals, leading to more than 800 deaths in 32 countries. This epidemic mobilized the World Health Organization, which launched travel restrictions to certain parts of the world for the first time in the last 50 years. The fact that coronaviruses, as many other viruses, crossed the species barrier to infect humans has posed a serious challenge to scientists involved in animal and human health. Control of coronavirus-induced diseases can only be the consequence of research on virus molecular biology and pathogenesis. This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.

Coronaviruses. --- Viral genetics. --- Virus genetics --- Viruses --- Microbial genetics --- Common cold viruses --- Coronaviridae --- Nidoviruses --- Genetics --- Medical virology. --- Virology. --- Medical microbiology --- Virology --- Virus diseases --- Coronavirus --- Virus Replication. --- genetics. --- Replication, Virus --- Replications, Virus --- Virus Replications --- DNA Replication --- Viral Replication --- Replication, Viral --- Replications, Viral --- Viral Replications --- Viral Replication Compartments --- Microbiology

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Provides historical background and comprehensive reviews of ten topics that cover the spectrum of the complex intracellular structures of prokaryotes: proteasomes, phycobilisomes, chlorosomes, gas vesicles, carboxysomes, magnetosomes, intracytoplasmic membranes, membrane-bound nucleoids, anammoxosomes, and cytoarchitecture of Epulopiscium spp.

Prokaryotic Cells --- Bacteria --- Cell Physiology. --- Intracellular Space --- Prokaryotes. --- Procaryotes --- cytology. --- physiology. --- Bacteria -- Cytology. --- Cell Physiological Phenomena. --- Intracellular Space -- Physiology. --- Prokaryotic Cells -- Cytology. --- Prokaryotes --- Phenomena and Processes --- Cellular Structures --- Organisms --- Body Fluid Compartments --- Cells --- Tissues --- Anatomy --- Cell Physiological Phenomena --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Ultrastructure --- Microorganisms. --- Germs --- Micro-organisms --- Microbes --- Microscopic organisms --- Monera --- Procaryotae --- Prokaryonta --- Prokaryotae --- Prokaryotic protists --- Life sciences. --- Biochemistry. --- Microbiology. --- Bacteriology. --- Life Sciences. --- Biochemistry, general. --- Microbiology --- Microorganisms --- Microbial biology --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Ultrastructure. --- Ultrastructure (Biology)