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Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century.
Medicine --- immunotoxin --- ribotoxin --- α-sarcin --- RNase T1 --- furin --- intracellular trafficking --- colorectal cancer --- botulinum toxin --- botulinum neurotoxin --- cancer --- cancer cells --- neuropathic pain --- post-surgical pain --- parotid gland --- submaxillary gland --- gustatory hyperhidrosis --- sialocele --- parotid fistula --- immunotherapy --- vaccine --- immune checkpoint inhibitors --- adoptive cell therapy --- cytokine therapy --- Coley’s Toxins --- glioblastoma --- drug discovery --- cytotoxic necrotizing factor type 1 --- protein purification --- recombinant protein production --- shiga toxins --- Gb3/CD77 --- apoptosis --- ER stress --- autophagy --- Burkitt lymphoma --- n/a --- Coley's Toxins
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This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt’s lymphoma with some clues for the potential future of Burkitt’s lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt’s lymphoma, including molecular biology, diagnosis, its association with AIDS and Malaria, immune responses, therapeutic approaches and a unique view from the bedside. This volume is comprehensive and unique and represents the most up-to-date clinical and research activities on Burkitt’s lymphoma.
Burkitt''s lymphoma. --- Epstein-Barr Virus Infections --- Lymphoma, B-Cell --- Lymphoma, Non-Hodgkin --- Tumor Virus Infections --- Herpesviridae Infections --- Lymphoma --- Lymphoproliferative Disorders --- DNA Virus Infections --- Virus Diseases --- Neoplasms, Experimental --- Neoplasms --- Neoplasms by Histologic Type --- Immunoproliferative Disorders --- Diseases --- Lymphatic Diseases --- Hemic and Lymphatic Diseases --- Immune System Diseases --- Burkitt Lymphoma --- Medicine --- Health & Biological Sciences --- Oncology --- Burkitt's lymphoma. --- African lymphoma --- Burkitt tumor --- Burkitt's African lymphoma --- Burkitt's tumor --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- B cells --- Epstein-Barr virus diseases --- Tumors --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect
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This Special Issue contains review articles focusing on several lymphoma entities included in the current WHO classification. The aim of the book is to guide the readers in understanding the evolution of lymphoma classification. The clinicopathological entities described in this issue have been analyzed through the molecular mechanisms involved in their pathogenesis.
Medicine --- lymphomas in PLWH --- KSHV/HHV8 --- EBV --- lymphoma classification --- management --- cART --- HLX --- HOXB9 --- NFIB --- PBX1 --- STAT3 --- TLX2 --- autoimmune hemolytic anemia --- cold agglutinin --- B-cell lymphoproliferative disorder --- lymphomagenesis --- methylation --- histone modification --- indolent --- T-cell --- NK-cell --- lymphoproliferative disorder --- gastrointestinal tract --- genetics --- cell of origin --- T follicular helper cells --- TFH lymphoma --- angioimmunoblastic T-cell lymphoma --- follicular T-cell lymphoma --- peripheral T-cell lymphoma of T-follicular helper immunophenotype --- peripheral T-cell lymphoma --- primary cutaneous B-cell lymphoma --- primary cutaneous marginal zone B-cell lymphoma --- primary cutaneous follicle centre lymphoma --- primary cutaneous diffuse large B-cell lymphoma, leg-type --- primary cutaneous diffuse large B-cell lymphoma, not otherwise specified --- intravascular B-cell lymphoma --- EBV+ mucocutaneous ulcer --- Burkitt lymphoma --- epidemiology --- Plasmodium falciparum --- Epstein Barr virus --- registry studies --- multimodal cancer --- non-Hodgkin lymphoma --- HIV/AIDS --- follicular lymphoma --- in situ follicular neoplasia --- FL transformation --- FL in young patients --- diffuse large B-cell lymphoma NOS --- high grade B-cell lymphoma --- lymphoma --- gene expression profiling --- tumor microenvironment --- diagnostics --- centrocytic lymphoma --- intermediate lymphocytic lymphoma --- Jaffe --- mantle cell lymphoma --- mantle zone lymphoma --- cyclin D1 --- lymphomas --- people living with HIV --- tumor prevention in people living with HIV --- KSHV --- BCL2 rearrangement --- genetic alterations --- histological transformation --- targeted therapies --- transformed follicular lymphoma --- lymphoproliferative neoplasms of uncertain biological significance --- monoclonal B-cell lymphocytosis --- “in situ” follicular neoplasia --- “in situ” mantle cell neoplasia --- atypical germinal centers --- large B-cell lymphoma with IRF4 rearrangement --- “in situ” high-grade B lymphomas --- Hodgkin lymphoma
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Tumor Virus Infections. --- Herpesvirus 4, Human. --- Herpesvirus 8, Human. --- Herpesviridae Infections --- Lymphoma --- Nasopharyngeal Neoplasms --- Risk Assessment. --- HHV-8 --- Herpesvirus, Kaposi's Sarcoma-Associated --- Human Herpesvirus 8 --- Kaposi's Sarcoma-Associated Herpesvirus --- Herpesvirus, Kaposi Sarcoma-Associated --- KSHV --- Kaposi Sarcoma-Associated Herpesvirus --- Herpesvirus, Kaposi Sarcoma Associated --- Herpesvirus, Kaposi's Sarcoma Associated --- Herpesvirus, Kaposis Sarcoma-Associated --- Herpesviruses, Kaposi's Sarcoma-Associated --- Kaposi Sarcoma Associated Herpesvirus --- Kaposi's Sarcoma Associated Herpesvirus --- Kaposi's Sarcoma-Associated Herpesviruses --- Kaposis Sarcoma-Associated Herpesvirus --- Sarcoma-Associated Herpesvirus, Kaposi --- Sarcoma-Associated Herpesviruses, Kaposi's --- Burkitt's Lymphoma Virus --- HHV-4 --- Herpesvirus 4 (gamma), Human --- Burkitt Herpesvirus --- Burkitt Lymphoma Virus --- E-B Virus --- EBV --- Epstein-Barr Virus --- Human Herpesvirus 4 --- Infectious Mononucleosis Virus --- Burkitts Lymphoma Virus --- E B Virus --- E-B Viruses --- Epstein Barr Virus --- Herpesvirus, Burkitt --- Infectious Mononucleosis Viruses --- Lymphoma Virus, Burkitt --- Mononucleosis Virus, Infectious --- Mononucleosis Viruses, Infectious --- Heatlh Risk Assessment --- Risks and Benefits --- Assessment, Risk --- Benefit-Risk Assessment --- Risk-Benefit Assessment --- Assessment, Benefit-Risk --- Assessment, Heatlh Risk --- Assessment, Risk-Benefit --- Assessments, Benefit-Risk --- Assessments, Heatlh Risk --- Assessments, Risk --- Assessments, Risk-Benefit --- Benefit Risk Assessment --- Benefit-Risk Assessments --- Benefits and Risks --- Heatlh Risk Assessments --- Risk Assessment, Heatlh --- Risk Assessments --- Risk Assessments, Heatlh --- Risk Benefit Assessment --- Risk-Benefit Assessments --- Infections, Tumor Virus --- Fibroma, Shope --- Papilloma, Shope --- Infection, Tumor Virus --- Shope Fibroma --- Shope Papilloma --- Tumor Virus Infection --- Neoplasms, Experimental --- Oncogenic Viruses --- complications. --- etiology. --- Conferences - Meetings --- Health Risk Assessment --- Assessment, Health Risk --- Assessments, Health Risk --- Health Risk Assessments --- Risk Assessment, Health --- Risk Assessments, Health --- Risk Analysis --- Analysis, Risk --- Risk Analyses --- Tumor Virus Infections --- Herpesvirus 4, Human --- Herpesvirus 8, Human --- Risk Assessment --- complications --- etiology --- Epstein-Barr virus. --- Kaposi's sarcoma. --- Carcinogens.
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