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Stroke is a global health problem affecting approximately 15 million people annually in the world and about 700,000 in the United States. It is the third leading cause of death and the most common cause of disability in most developed countries. Acute Ischemic Injury and Repair in the Nervous System is intended to provide the most up-to-date knowledge of the mechanisms of neuronal death and repair after stroke. It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.

Cerebral ischemia --- Nervous system --- Molecular aspects. --- Regeneration --- Organs (Anatomy) --- Neurosciences --- Brain ischemia --- Cerebrovascular disease --- Ischemia --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences

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(will follow).

Cell proliferation --- Cerebral ischemia --- Nervous system --- Molecular aspects. --- Regeneration. --- Nerve regeneration --- Nervous system regeneration --- Neural regeneration --- Neuron regeneration --- Nerve grafting --- Regeneration (Biology) --- Brain ischemia --- Cerebrovascular disease --- Ischemia --- Molecular biology --- Degeneration and regeneration --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences

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This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Cerebral ischemia. --- Reperfusion injury. --- Medicine. --- Neurosciences. --- Neurology. --- Biomedicine. --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Diseases --- Injury, Reperfusion --- Ischemia --- Brain ischemia --- Cerebrovascular disease --- Neurology .

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Brain Hypoxia and Ischemia Gabriel G. Haddad, M.D. and Shan Ping Yu, M.D., Ph.D., Editors Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice. Gabriel G. Haddad, M.D. is Professor of Pediatrics and Neuroscience and Chair of the Department of Pediatrics at the University of California, San Diego. He is also Physician-in-Chief at Rady Children’s Hospital in San Diego. Shan Ping Yu, M.D., Ph.D. is Professor of Anesthesiology at Emory University in Atlanta, GA.

Cerebral anoxia. --- Cerebral ischemia. --- Cerebral anoxia --- Cerebral ischemia --- Brain Diseases --- Cerebrovascular Disorders --- Brain Ischemia --- Hypoxia, Brain --- Central Nervous System Diseases --- Vascular Diseases --- Nervous System Diseases --- Cardiovascular Diseases --- Diseases --- Human Anatomy & Physiology --- Medicine --- Neuroscience --- Neurology --- Health & Biological Sciences --- Ischemia. --- Ischaemia --- Anoxia, Cerebral --- Brain anoxia --- Brain hypoxia --- Hypoxia cerebral --- Medicine. --- Human physiology. --- Neurosciences. --- Neurology. --- Neurobiology. --- Biomedicine. --- Human Physiology. --- Blood circulation disorders --- Anoxemia --- Cerebrovascular disease --- Neurosciences --- Nervous system --- Neuropsychiatry --- Human biology --- Medical sciences --- Physiology --- Human body --- Neural sciences --- Neurological sciences --- Neurology .

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This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, new chapters are included on the clinical ischemic penumubra and the use of advanced neuroimaging to select patients for neurointerventional procedures. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.

Cerebral infarction. --- Cerebral ischemia -- Treatment. --- Cerebral ischemia. --- Cerebrovascular disease -- Imaging. --- Cerebrovascular disease -- Treatment. --- Diagnostic Techniques and Procedures --- Cerebrovascular Disorders --- Brain Ischemia --- Stroke --- Diagnostic Imaging --- Diagnosis --- Brain Diseases --- Vascular Diseases --- Central Nervous System Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cardiovascular Diseases --- Diseases --- Nervous System Diseases --- Medicine --- Neurology --- Radiology, MRI, Ultrasonography & Medical Physics --- Health & Biological Sciences --- Cerebrovascular disease. --- Cerebrovascular disease --- Imaging. --- Apoplexy --- Brain --- Cerebral circulation disorders --- Cerebral vascular accident --- Cerebrovascular accident --- Cerebrovascular disorders --- Cerebrovascular syndrome --- CVA (Disease) --- Blood-vessels --- Medicine. --- Emergency medicine. --- Radiology. --- Neuroradiology. --- Cardiology. --- Neurology. --- Neurosurgery. --- Medicine & Public Health. --- Imaging / Radiology. --- Emergency Medicine. --- Neglect (Neurology) --- Cerebral Ischemia --- Medical