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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Science: general issues --- Pharmacology --- drug discovery --- animal model --- neuropharmacology --- neurodegeneration --- brain ischemia --- addiction --- alzheimer's disease
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Stroke is a global health problem affecting approximately 15 million people annually in the world and about 700,000 in the United States. It is the third leading cause of death and the most common cause of disability in most developed countries. Acute Ischemic Injury and Repair in the Nervous System is intended to provide the most up-to-date knowledge of the mechanisms of neuronal death and repair after stroke. It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.
Cerebral ischemia --- Nervous system --- Molecular aspects. --- Regeneration --- Organs (Anatomy) --- Neurosciences --- Brain ischemia --- Cerebrovascular disease --- Ischemia --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences
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This book covers all aspects and the most vibrant topics of ischemic stroke research: from basic sciences to latest methods of clinical applications. The authors give an overview of what has importance today in stroke research and also strike future ideas. The diversity of origin of the internationally known authors underlines not only that ischemic stroke research is nowadays global but also that this diversity gives new and valuable inputs to treat our patients.
Brain --- Cerebral ischemia. --- Ischemia. --- Cerebrum --- Mind --- Central nervous system --- Head --- Brain ischemia --- Cerebrovascular disease --- Ischemia --- Medicine --- Cardiogeriatrics --- Cardiology and Cardiovascular Medicine --- Health Sciences
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Cell proliferation --- Cerebral ischemia --- Nervous system --- Molecular aspects. --- Regeneration. --- Nerve regeneration --- Nervous system regeneration --- Neural regeneration --- Neuron regeneration --- Nerve grafting --- Regeneration (Biology) --- Brain ischemia --- Cerebrovascular disease --- Ischemia --- Molecular biology --- Degeneration and regeneration --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences
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Cerebrovascular Disorders --- Brain Ischemia --- Evidence-Based Practice --- Clinical Medicine --- Vascular Diseases --- Health Occupations --- Brain Diseases --- Medicine --- Central Nervous System Diseases --- Disciplines and Occupations --- Cardiovascular Diseases --- Nervous System Diseases --- Diseases --- Evidence-Based Medicine --- Ischemic Attack, Transient --- Stroke
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This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.
Cerebral ischemia. --- Reperfusion injury. --- Medicine. --- Neurosciences. --- Neurology. --- Biomedicine. --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Diseases --- Injury, Reperfusion --- Ischemia --- Brain ischemia --- Cerebrovascular disease --- Neurology .
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Cerebral ischemia from cardiac arrest, stroke, and subarachnoid and intracerebral hemorrhage, together with trauma, epilepsy, and other CNS pathologies, continue to impose immense burdens of morbidity and mortality the world over. Despite many decades of research aimed at understanding the genetic and molecular basis of these pathologies, therapeutics developed on the basis of blocking ‘known’ injury mechanisms can actually claim few clinical successes. The field of CNS “preconditioning” was born from the preclinical finding more than 20 years ago that intentional activation of innate, cytoprotective factors could provide robust protection, or “tolerance” against cerebral ischemic injury. Herein, up-to-date summaries on all aspects of preconditioning for CNS disease, including the emerging topics of postconditioning and remote pre- and post-conditioning, are provided by the leading scientists in the field. The translational potential of both preclinical and clinical advances is underscored throughout, with the hope of accelerating the bench-to-bedside success of endogenous cytoprotection as a therapeutic strategy. Jeffrey M. Gidday PhD, Associate Professor of Neurosurgery at Washington University School of Medicine, has been working in the field of CNS preconditioning for 18 years, and has numerous publications on preconditioning-induced protection in the setting of several different cerebral and retinal pathologies. Miguel A. Perez-Pinzon PhD is Professor of Neurology/Neuroscience, Vice-Chair for Basic Science of Neurology at the University of Miami Miller School of Medicine. He began studies of ischemic preconditioning in 1995 and for many years prior to that worked in the field of anoxia tolerance, publishing close to 50 peer-reviewed articles and many book chapters on these topics. John H. Zhang MD PhD is Professor of Neurosurgery, Anesthesiology, and Physiology, and Vice-Chair of the Basic Science Department at the Loma Linda University School of Medicine. His research interests include stroke and medical gases, and he has published papers related to pre-, post- and remote-conditioning in subarachnoid hemorrhage, focal cerebral ischemia, and neonatal brain injury.
Central nervous system -- Diseases. --- Central nervous system diseases -- Therapy. --- Neuroprotective agents. --- Neuroprotective agents --- Investigative Techniques --- Cerebrovascular Disorders --- Protective Agents --- Therapeutics --- Central Nervous System Agents --- Therapeutic Uses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physiological Effects of Drugs --- Vascular Diseases --- Brain Diseases --- Pharmacologic Actions --- Central Nervous System Diseases --- Cardiovascular Diseases --- Chemical Actions and Uses --- Nervous System Diseases --- Diseases --- Chemicals and Drugs --- Brain Ischemia --- Methods --- Ischemic Postconditioning --- Neuroprotective Agents --- Ischemic Preconditioning --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neurology --- Neuroscience --- Central nervous system. --- Central nervous system --- Cerebral ischemia. --- Diseases. --- Brain ischemia --- Nervous system, Central --- Neurosciences. --- Neurology. --- Neurobiology. --- Cerebrovascular disease --- Ischemia --- Nervous system --- Neurosciences --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Medical sciences --- Neurology .
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Brain Hypoxia and Ischemia Gabriel G. Haddad, M.D. and Shan Ping Yu, M.D., Ph.D., Editors Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice. Gabriel G. Haddad, M.D. is Professor of Pediatrics and Neuroscience and Chair of the Department of Pediatrics at the University of California, San Diego. He is also Physician-in-Chief at Rady Children’s Hospital in San Diego. Shan Ping Yu, M.D., Ph.D. is Professor of Anesthesiology at Emory University in Atlanta, GA.
Cerebral anoxia. --- Cerebral ischemia. --- Cerebral anoxia --- Cerebral ischemia --- Brain Diseases --- Cerebrovascular Disorders --- Brain Ischemia --- Hypoxia, Brain --- Central Nervous System Diseases --- Vascular Diseases --- Nervous System Diseases --- Cardiovascular Diseases --- Diseases --- Human Anatomy & Physiology --- Medicine --- Neuroscience --- Neurology --- Health & Biological Sciences --- Ischemia. --- Ischaemia --- Anoxia, Cerebral --- Brain anoxia --- Brain hypoxia --- Hypoxia cerebral --- Medicine. --- Human physiology. --- Neurosciences. --- Neurology. --- Neurobiology. --- Biomedicine. --- Human Physiology. --- Blood circulation disorders --- Anoxemia --- Cerebrovascular disease --- Neurosciences --- Nervous system --- Neuropsychiatry --- Human biology --- Medical sciences --- Physiology --- Human body --- Neural sciences --- Neurological sciences --- Neurology .
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More than 60 papers written by internationally recognized experts cover the broad spectrum of brain edema. The main topics treated are: ischemia & hemorrhage, trauma (experimental and clinical), cerebral hemorrhage, tumor, hydrocephlaus & intracranial pressure (ICP), neuromonitoring & neuroimaging, treatments, blood brain barrier, and miscellaneous.
Brain -- Wounds and injuries -- Congresses. --- Brain edema -- Congresses. --- Brain injuries -- Congresses. --- Cerebral edema -- Congresses. --- Intracranial Hemorrhage, Traumatic --- Brain Injuries --- Cerebrovascular Disorders --- Brain Diseases --- Cerebrospinal Fluid Pressure --- Intracranial Hypertension --- Craniocerebral Trauma --- Nervous System Physiological Phenomena --- Central Nervous System Diseases --- Intracranial Hemorrhages --- Vascular Diseases --- Trauma, Nervous System --- Nervous System Diseases --- Musculoskeletal and Neural Physiological Phenomena --- Cardiovascular Diseases --- Wounds and Injuries --- Diseases --- Phenomena and Processes --- Brain Hemorrhage, Traumatic --- Intracranial Pressure --- Brain Edema --- Brain Ischemia --- Hydrocephalus --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Cerebral edema --- Brain --- Physiology --- Cerebrum --- Mind --- Brain edema --- Edema --- Medicine. --- Neurosurgery. --- Medicine & Public Health. --- Central nervous system --- Head --- Nerves --- Neurosurgery --- Surgery --- Nervous system --- Surgery.
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This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, new chapters are included on the clinical ischemic penumubra and the use of advanced neuroimaging to select patients for neurointerventional procedures. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
Cerebral infarction. --- Cerebral ischemia -- Treatment. --- Cerebral ischemia. --- Cerebrovascular disease -- Imaging. --- Cerebrovascular disease -- Treatment. --- Diagnostic Techniques and Procedures --- Cerebrovascular Disorders --- Brain Ischemia --- Stroke --- Diagnostic Imaging --- Diagnosis --- Brain Diseases --- Vascular Diseases --- Central Nervous System Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cardiovascular Diseases --- Diseases --- Nervous System Diseases --- Medicine --- Neurology --- Radiology, MRI, Ultrasonography & Medical Physics --- Health & Biological Sciences --- Cerebrovascular disease. --- Cerebrovascular disease --- Imaging. --- Apoplexy --- Brain --- Cerebral circulation disorders --- Cerebral vascular accident --- Cerebrovascular accident --- Cerebrovascular disorders --- Cerebrovascular syndrome --- CVA (Disease) --- Blood-vessels --- Medicine. --- Emergency medicine. --- Radiology. --- Neuroradiology. --- Cardiology. --- Neurology. --- Neurosurgery. --- Medicine & Public Health. --- Imaging / Radiology. --- Emergency Medicine. --- Neglect (Neurology) --- Cerebral Ischemia --- Medical
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