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Malignant mesothelioma is an aggressive and fatal neoplasm of serous membranes. The pathogenesis of malignant mesothelioma is clearly linked to incorporated asbestos fibers. Owing to the late banning of asbestos use in industrial nations and the continuing mining and consumption of asbestos in many countries, the incidence of malignant mesothelioma is still rising worldwide. This book covers all the important aspects of the disease by bringing together contributions from selected experts in the fields of epidemiology, imaging, pathological diagnosis, therapy, genetics, and screening. Special emphasis is placed on the latest diagnostic techniques and current therapy standards. In addition, the mineralogy of asbestos is reviewed and clear advice is included on the analysis of tissue mineral fiber content. By providing a compact, scientifically based, and up-to-date overview of the management of malignant mesothelioma, this volume will be invaluable for all clinicians and pathologists who are engaged in the diagnosis and treatment of the disease or in related research.

Asbestos -- adverse effects. --- Asbestosis -- Toxicology. --- Mesothelioma -- Miscellanea. --- Mesothelioma. --- Silicates --- Neoplasms, Mesothelial --- Adenoma --- Silicic Acid --- Neoplasms, Glandular and Epithelial --- Minerals --- Neoplasms by Histologic Type --- Inorganic Chemicals --- Silicon Dioxide --- Neoplasms --- Silicon Compounds --- Chemicals and Drugs --- Diseases --- Asbestos --- Mesothelioma --- Medicine --- Health & Biological Sciences --- Oncology --- Mesothelial Neoplasms --- Mesothelial Neoplasm --- Neoplasm, Mesothelial --- Silicate --- Mesotheliomas --- Compounds, Silicon --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Aerosil --- Aerosil 380 --- Cristobalite --- Quso G-32 --- Quso G32 --- Tridymite --- Silica --- 380, Aerosil --- Dioxide, Silicon --- G32, Quso --- Quso G 32 --- Chemicals, Inorganic --- Histological Type of Neoplasm --- Histological Types of Neoplasms --- Neoplasms by Histological Type --- Neoplasm Histological Type --- Neoplasm Histological Types --- Neoplasms Histological Type --- Neoplasms Histological Types --- Epithelial Neoplasms --- Glandular Neoplasms --- Glandular and Epithelial Neoplasms --- Neoplasms, Epithelial --- Neoplasms, Glandular --- Neoplasms, Glandular Epithelial --- Epithelial Neoplasm --- Epithelial Neoplasm, Glandular --- Epithelial Neoplasms, Glandular --- Glandular Epithelial Neoplasm --- Glandular Epithelial Neoplasms --- Glandular Neoplasm --- Neoplasm, Epithelial --- Neoplasm, Glandular --- Neoplasm, Glandular Epithelial --- Adenoma, Basal Cell --- Adenoma, Follicular --- Adenoma, Microcystic --- Adenoma, Monomorphic --- Adenoma, Papillary --- Adenoma, Trabecular --- Adenomas --- Adenomas, Basal Cell --- Adenomas, Follicular --- Adenomas, Microcystic --- Adenomas, Monomorphic --- Adenomas, Papillary --- Adenomas, Trabecular --- Basal Cell Adenoma --- Basal Cell Adenomas --- Follicular Adenoma --- Follicular Adenomas --- Microcystic Adenoma --- Microcystic Adenomas --- Monomorphic Adenoma --- Monomorphic Adenomas --- Papillary Adenoma --- Papillary Adenomas --- Trabecular Adenoma --- Trabecular Adenomas --- Hydrated Silica Gel --- Silica Hydrate --- Silicate Hydrate --- Gel, Hydrated Silica --- Hydrate, Silica --- Hydrate, Silicate --- Silica Gel, Hydrated --- Medicine. --- Oncology. --- Medicine & Public Health. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diagnosis. --- Treatment. --- Mesothelium --- Oncology  .

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S. González-Moreno (Ed. ) Advances in Peritoneal Surface Oncology With 45 Figures in 57 Separate Illustrations, 12 in Color and 19 Tables 123 IV Preface Santiago González-Moreno, MD, PhD Department of Surgical Oncology Centro Oncológico MD Anderson International España Calle Gómez Hemans 2 28033 Madrid Spain sgonzalez@mdanderson. es Library of Congress Control Number: 2006937141 ISSN 0080-0015 ISBN 978-3-540-30759-4 Springer Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, speci? ?cally the rights of translation, reprinting, reuse of illustrations, recitations, broadcasting, reproduction on micro? ?lm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is part of Springer Science+Business Media http//www. springer. com Springer-Verlag Berlin Heidelberg 2007 Printed in Germany The use of general descriptive names, trademarks, etc. in this publication does not imply, even in the absence of a speci? ?c sta- ment, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every case the user must check such information by consulting the relevant literature.

Medicine & Public Health. --- Oncology. --- Medicine. --- Médecine --- Cancérologie --- Peritoneum -- Cancer -- Treatment. --- Peritoneum --- Carcinoma --- Drug Therapy --- Peritoneal Neoplasms --- Mesothelioma --- Neoplasms, Mesothelial --- Peritoneal Diseases --- Therapeutics --- Digestive System Neoplasms --- Adenoma --- Abdominal Neoplasms --- Neoplasms, Glandular and Epithelial --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Digestive System Diseases --- Neoplasms by Histologic Type --- Neoplasms by Site --- Diseases --- Neoplasms --- Gastroenterology --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Treatment --- Treatment. --- Tumors --- Chemotherapy. --- Abdomen --- Membranes (Biology)

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Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, rendering oncology well along the path to “personalised cancer medicine”. Thanks to developments in genetics, several mutations and gene rearrangements have been identified in patients with endocrine cancers (e.g., thyroid and adrenocortical carcinoma). In particular, each patient can be considered as a unique, individual one, with unique genetic information. The aim of this Special Issue is to offer an overview of exciting new research in the area of endocrine tumours may set the stage for an innovative personalised management and precision medicine modalities for individualised care.New affordable individual genomic analyses, as well as the opportunity to test new compounds in primary cells may allow a personalised management of patients with endocrine malignancies. This approach may improve the prediction of clinical outcome and therapeutic effectiveness, as well as help to avoid the use of ineffective drugs. However, further efforts are needed to obtain an adjustment of clinical management in patients with endocrine cancers that would rely solely or in great part on genetic information. This Special Issue includes basic, translational, and clinical papers on personalised medicine in endocrine malignancies (i.e., thyroid and adrenal), especially focusing on diagnostic and prognostic biomarkers, as well as novel drug targets or targeted treatments, including eventual clinical trials.

Medicine --- papillary thyroid cancer --- SUV PET/CT --- BRAF V600E --- immune checkpoint inhibitors (ICIs) --- ipilimumab --- nivolumab --- prolactinoma --- Cushing’s disease --- aggressive pituitary tumor --- aggressive PitNET --- aggressive pituitary adenoma --- pituitary carcinoma --- adrenocortical cancer --- adrenal adenomas --- adrenal tumors --- p53 --- p27 --- ki-67 --- reticulin --- mitotane --- adjuvant treatment --- recurrence --- recurrence free survival --- timing --- intratumoral heterogeneity --- thyroid tumor --- BRAF --- RET/PTC rearrangements --- RAS mutation --- adrenal cortex --- carcinoma --- angiogenesis --- gene expression --- osteopontin --- hyaluronan synthase 1 --- multikinase inhibitors --- sorafenib --- lenvatinib --- differentiated thyroid cancer --- radioiodine resistance --- predictive marker --- predictors --- response to treatment --- survival --- information needs and preferences --- focus group interview --- personalized medicine --- neuroendocrine tumours --- phaeochromocytoma --- paraganglioma --- molecular clusters --- n/a --- Cushing's disease

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Diagnostic Imaging --- Diabetes, Gestational --- Contraception --- Infertility, Female --- Infertility, Male --- Growth Disorders --- Puberty --- Menopause --- Andropause --- Osteoporosis --- Cardiovascular Diseases --- Hypertension --- Hypoglycemia --- Adenoma --- Diabetes Mellitus, Type 1 --- Diabetes Mellitus, Type 2 --- Goiter --- Thyroid Nodule --- Hemochromatosis --- Hyperthyroidism --- Hypothyroidism --- Kidney Failure, Acute --- Amenorrhea --- Hypercalcemia --- Erectile Dysfunction --- Diagnostic imaging --- Diabetes in pregnancy --- Growth disorders --- Climacteric, Male --- Cardiovascular system --- Diabetes --- Thyroid gland --- Acute renal failure --- Impotence --- Imagerie pour le diagnostic --- Diabète chez la femme enceinte --- Stérilité féminine --- Stérilité masculine --- Troubles de la croissance --- Puberté --- Ménopause --- Ostéoporose --- Appareil cardiovasculaire --- Hypertension artérielle --- Hypoglycémie --- Adénome --- Diabète insulinodépendant --- Goitre --- Thyroïde --- Hémochromatose --- Hyperthyroïdie --- Hypothyroïdie --- Insuffisance rénale aiguë --- Aménorrhée --- Hypercalcémie --- Impuissance sexuelle --- prevention & control --- Adults --- complications --- Diseases --- Cancer --- Tumors --- Maladies --- Tumeurs --- Internship and Residency --- Endocrinology --- Diabetes Mellitus --- Endocrine Diseases --- Acute Kidney Injury. --- Diabète chez la femme enceinte --- Stérilité féminine --- Stérilité masculine --- Puberté --- Ménopause --- Ostéoporose --- Hypertension artérielle --- Hypoglycémie --- Adénome --- Diabète insulinodépendant --- Thyroïde --- Hémochromatose --- Hyperthyroïdie --- Hypothyroïdie --- Insuffisance rénale aiguë --- Aménorrhée --- Hypercalcémie --- Hypothyroidism. --- Diagnostic Imaging. --- Diabetes, Gestational. --- Contraception. --- Infertility, Female. --- Infertility, Male. --- Growth Disorders. --- Puberty. --- Menopause. --- Andropause. --- Osteoporosis. --- Hypoglycemia. --- Adenoma. --- Goiter. --- Thyroid Nodule. --- Hemochromatosis. --- Hyperthyroidism. --- Amenorrhea. --- Hypercalcemia. --- Erectile Dysfunction. --- prevention & control. --- Adults. --- complications. --- Endocrinology - textbooks --- Diabetes Mellitus - textbooks --- Endocrine Diseases - textbooks --- Endocrine system diseases --- Cardiovascular diseases --- Thyroid nodule --- Kidney failure, --- Erectile dysfunction --- Complications --- Acute

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This reprint includes 15 articles in the field of non-communicable Diseases, big data, and artificial intelligence, overviewing the most recent advances in the field of AI and their application potential in 3P medicine.

Medicine --- artificial intelligence --- computer-aided diagnosis --- facial phenotypes --- machine learning --- complexity theory --- dementia --- cognitive dysfunction --- neuropsychological tests --- mental status and dementia tests --- spontaneous intracerebral hemorrhage (SICH) --- 90-day function outcome --- mortality --- osteoarthritis --- venous thrombosis --- VTE risk prediction --- machine learning algorithm --- population-based cohort study --- pituitary adenoma --- craniopharyngioma --- optic chiasm --- multicenter --- treatment outcome --- liver neoplasms --- deep learning --- diabetic complication --- gene-gene interaction --- AGER --- IL6R --- multiple sclerosis --- DNA methylation --- entropy --- atherosclerosis --- plaque characterization --- physical activity --- osteoporosis --- osteoporotic fracture --- vertebral fracture --- hip fracture --- distal radius fracture --- small for gestational age --- exposure to radiation --- prediction --- coronary plaque --- major adverse cardiovascular events --- coronary artery disease --- coronary computed tomographic angiography --- acute pancreatitis --- predictor --- interventions --- type 2 diabetes mellitus (T2DM) --- prediction model --- Chinese elderly --- prediabetes --- incident diabetes --- predictive models