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Year: 2019 Publisher: Paris : OECD Publishing,
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Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic reactions when activated by light at otherwise non-toxic doses. Phototoxicity can be categorized as photoirritation, photoallergy, and photogenotoxicity. The purpose of this test is to measure the phototoxicity of a chemical. The main event in any phototoxic reaction is the absorption of photons of a wavelength that induces the excitation of the chromophore. Excitation energy is often transferred to oxygen molecules, followed by the generation of ROS (reactive Oxygen Species). Measurements are performed using a spectrometer. The determination of the ROS generation from irradiated chemicals with simulated sunlight is indicative of phototoxic potential.
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Year: 2019 Publisher: Paris : OECD Publishing,
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La phototoxicité est définie comme une réaction toxique causée par des produits chimiques photoréactifs administrés par voie topique ou systémique, après exposition du corps à la lumière ambiante. Plusieurs classes de produits chimiques photoréactifs peuvent provoquer des réactions phototoxiques lorsqu'ils sont activés par la lumière, à des doses ne présentant pas d'autres effets toxiques. La phototoxicité peut être subdivisée en photo-irritation, photoallergie et photogénotoxicité. Le but de cet essai est de mesurer la phototoxicité d'un produit chimique. L'événement principal dans toute réaction phototoxique est l'absorption des photons d'une longueur d'onde qui induit l'excitation du chromophore. L'énergie d'excitation est souvent transférée aux molécules d'oxygène, suivies par la génération de ROS (Reactive Oxygene Species). Les mesures sont effectuées à l'aide d'un spectromètre. La détermination de la génération ROS à partir de produits chimiques irradiés avec la lumière du soleil simulée est révélateur d'un potentiel phototoxique.
Active oxygen --- Photochemistry. --- Toxicity testing. --- Physiological effect.
Book
ISBN: 0444009248 Year: 1984 Volume: v. 26 Publisher: New York : Elsevier,
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Oxygen. --- Oxygen --- Active oxygen --- Active oxygen in the body --- Oxygène actif dans l'organisme --- toxicity.
ISBN: 3110097044 9783110097047 Year: 1984 Publisher: Berlin,New York : W. de Gruyter,
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Active oxygen --- Radicals (Chemistry) --- Oxygen --- Congresses --- Congresses. --- congresses.
ISBN: 0849363632 Year: 1992 Publisher: Boca Raton, Fla. : CRC Press,
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Active oxygen in the body --- Cell-mediated cytotoxicity --- Leucocytes --- Congresses --- Congresses.
ISBN: 0080417493 1322269319 1483287661 9780080417493 Year: 1991 Publisher: New York : Pergamon Press,
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Active oxygen --- Active oxygen in the body --- Antioxidants --- Free radicals (Chemistry) --- Lipids --- Free Radicals --- Oxygen --- Pathophysiology --- Congresses --- Therapeutic use --- Peroxidation --- congresses --- adverse effects --- physiology --- congresses. --- Lipids - Peroxidation - Congresses --- Antioxidants - Therapeutic use - Congresses --- Free radicals (Chemistry) - Pathophysiology - Congresses --- Active oxygen - Pathophysiology - Congresses --- Active oxygen in the body - Congresses --- Oxygen - adverse effects - congresses --- Antioxidants - congresses --- Free Radicals - congresses
ISBN: 0751402923 0751403717 9400708742 0412034417 Year: 1995 Volume: 2 Publisher: Glasgow : Blackie,
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Active oxygen --- OXYGEN --- SUPEROXIDE --- PEROXIDES --- ATMOSPHERE (EARTH) --- WATERS, NATURAL --- OXIDATION --- CATALYSIS --- REACTIONS
ISSN: 15667693 ISBN: 1586035185 Year: 2005 Volume: v. 367 Publisher: Amsterdam : IOS Press,
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Free radicals (Chemistry) --- Active oxygen --- Radicaux libres (Chimie) --- Oxygène actif --- Pathophysiology. --- Physiopathologie --- FREE RADICALS --- METABOLISM
ISBN: 0849354528 Year: 1991 Publisher: Boca Raton, Fla. : CRC Press,
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Active oxygen in the body --- Superoxides --- Oxygène actif dans l'organisme --- Congresses.
ISBN: 0444509577 Year: 2001 Publisher: New York : Elsevier,
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Active oxygen --- Biochemical markers. --- Stress (Physiology) --- Oxygène actif --- Marqueurs biologiques --- Stress --- Pathophysiology. --- Physiopathologie
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