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The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
Chemistry. --- Organic chemistry. --- Medicinal chemistry. --- Medical biochemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Medical Biochemistry. --- Chemistry, Organic. --- Organic chemistry --- Chemistry --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Clinical biochemistry.
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The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, and H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- Chemistry, Organic. --- Natural products --- Biotechnology. --- Organic chemistry --- Biotechnology --- Biochemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Medical Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Organic chemistry. --- Medicinal chemistry. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Pathology --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Clinical biochemistry.
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The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis. The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.
Chemistry. --- Pharmaceutical technology. --- Organic chemistry. --- Medicinal chemistry. --- Organic Chemistry. --- Pharmaceutical Sciences/Technology. --- Medicinal Chemistry. --- Chemistry, Organic. --- Pharmaceutical chemistry. --- Clinical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Organic chemistry --- Chemistry --- Biochemistry --- Pathology --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Composition --- Pharmaceutics.
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The first contribution presents coumarins, the largest group of 1-benzopyran derivatives found in plants. Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. The second contribution presents a comprehensive survey of the many aspects of PAD biochemistry and physiology. The third contribution gives a comprehensive overview of secondary metabolites from higher fungi, with more than 700 references highlighting the isolation, structure elucidation, biological activities, chemical synthesis, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms. .
Chemistry, Organic. --- Organic chemistry --- Chemistry. --- Pharmaceutical technology. --- Organic chemistry. --- Medicinal chemistry. --- Organic Chemistry. --- Pharmaceutical Sciences/Technology. --- Medicinal Chemistry. --- Chemistry --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Composition --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Pharmaceutical chemistry. --- Pharmaceutics.
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The first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids. The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.
Medicinal chemistry. --- Pharmaceutical Sciences/Technology. --- Chemistry. --- Pharmaceutical technology. --- Organic chemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Organic chemistry --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Physical sciences --- Chemistry, Organic. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Pharmaceutical chemistry. --- Pharmaceutics.
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The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.
Cannabis --- Therapeutic use. --- Cannabis gigantea --- Cannabis indica --- Cannabis sativa --- Gallow grass --- Chemistry. --- Organic chemistry. --- Medicinal chemistry. --- Medical biochemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Medical Biochemistry. --- Cannabaceae --- Marijuana --- Chemistry, Organic. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Organic chemistry --- Composition --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Clinical biochemistry.
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Pharmacognosy --- farmacie --- pharmacy --- Pharmacology. Therapy --- farmacologie --- Pharmacognosie --- Phytothérapie --- Materia medica, Vegetable --- Plants, Medicinal --- Phytotherapy --- methods --- Plants, Medicinal. --- Pharmacognosy. --- Materia medica, Vegetable. --- Phytothérapie --- methods. --- besmettelijke ziekten --- pharmacy [discipline]
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Pharmacognosy. --- Materia medica, Vegetable. --- Plants, Medicinal. --- Materia medica, Vegetable --- Pharmacognosie --- Phytothérapie --- Pharmacognosy --- Plantes médicinales --- Phytothérapie --- Plantes médicinales. --- Phytothérapie. --- Phytotherapy --- Plants, medicinal
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The first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types. The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan alkaloids known to date. The reported pharmacological activities of the new and known alkaloids showed a greater bias towards central nervous system and related activities. Other prominent activities reported were antifeedant or insecticidal, cytotoxicity/antitumor/anticancer/estrogenic, antiprotozoal, antiinflammatory, antioxidant, antifungal and antiviral activities.
Chemistry, Organic. --- Natural products --- Biotechnology. --- Pharmaceutical technology. --- Biochemistry. --- Organic Chemistry. --- Pharmaceutical Sciences/Technology. --- Medicinal Chemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Organic chemistry --- Composition --- Organic chemistry. --- Medicinal chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Pharmaceutical chemistry. --- Pharmaceutics.
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Quatrième de couverture : "Pharmacognosy (the science of biogenic or nature-derived pharmaceuticals and poisons) has been an established basic pharmaceutical science taught in institutions of pharmacy education for over two centuries. Over the past 20 years though it has become increasingly important given the explosion of new drugs, phytomedicines (plant medicines), nutraceuticals and dietary supplements – all of which need to be fully understood, tested and regulated. From a review of the previous edition : ‘Drawing on their wealth of experience and knowledge in this field, the authors, who are without doubt among the finest minds in pharmacognosy today, provide useful and fascinating insights into the history, botany, chemistry, phytotherapy and importance of medicinal plants in some of today’s healthcare systems. This is a landmark textbook, which carefully brings together relevant data from numerous sources and provides, in an authoritative and exhaustive manner, cutting-edge information that is relevant to pharmacists, pharmacognocists, complementary practitioners, doctors and nurses alike.’ The Pharmaceutical Journal. ‘This is an excellent text book which provides fascinating insights into the world of pharmacognosy and the authors masterfully integrated elements of orthodox pharmacognosy and phytotherapy. Both the science student and the non-scientific person interested in phytotherapy will greatly benefit from reading this publication. It is comprehensive, easy to follow and after having read this book, one is so much more aware of the uniqueness of phytomedicines. A must read for any healthcare practitioner.’ Covers the history, biology and chemistry of plant-based medicines. Covers pharmaceutical and neutraceuticals derived from plants. Covers the role of medicinal plants in worldwide healthcare systems. Examines the therapeutics and evidence of plant-based medicines by body system. Sections on regulatory information expanded. New evidence updates throughout. New material covering non-medical supplements. Therapeutics updated throughout"
Phytotherapie. --- Pharmazeutische Biologie. --- Plants, Medicinal --- Pharmacognosy --- Phytotherapy --- methods --- Pharmacognosie --- Plantes médicinales --- Phytothérapie --- Materia medica, Vegetable --- Pharmacognosie. --- Plantes médicinales. --- Phytothérapie. --- Botanical drugs --- Drugs from plants --- Medicinal plants --- Plant drugs --- Vegetable drugs --- Materia medica --- Botanical drug industry --- Botany, Medical --- Pharmacognostics --- Drugs --- Pharmacy --- Healing Plants --- Medicinal Plants --- Pharmaceutical Plants --- Herbs, Medicinal --- Medicinal Herbs --- Healing Plant --- Herb, Medicinal --- Medicinal Herb --- Medicinal Plant --- Pharmaceutical Plant --- Plant, Healing --- Plant, Medicinal --- Plant, Pharmaceutical --- Plants, Healing --- Plants, Pharmaceutical --- Pharmaceutical Preparations --- Medicine, Traditional --- Ethnopharmacology --- Herbal Medicine --- Therapeutic use --- Pharmacognosy - methods --- Phytotherapy - methods --- Plants, Medicinal. --- methods.
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