Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

APS (Acta Pharmacologica Sinica) publishes high quality content in all areas of pharmacology and the life sciences. Topics of particular interest include, but are not limited to, anticancer pharmacology, cardiovascular and pulmonary pharmacology, clinical pharmacology, drug discovery, gastrointestinal and hepatic pharmacology, genitourinary, renal and endocrine pharmacology, immunopharmacology and inflammation, molecular and cellular pharmacology, neuropharmacology, pharmaceutics and pharmacokinetics.

farmacologie --- Chinese geneeskunde --- Pharmacology. Therapy --- Pharmacology --- Pharmacology. --- Health Sciences --- Pharmacy and Pharmacology --- Pharmacologies --- Pharmaceutical Preparations --- Drug effects --- Medical pharmacology --- pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Medicine --- Immunology --- Medical microbiology --- Vaccines --- Internal medicine --- Biomedicine, general --- Pharmacology/Toxicology --- Medical Microbiology --- Internal Medicine --- Vaccine --- Immunobiology --- Life sciences --- Serology --- Health Workforce --- Medicine, Internal --- Biologicals

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.

Inflammation. --- T cells. --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Lymphocytes --- Inflammatory process --- Pathology --- Anti-inflammatory agents --- Neuropathology --- Immunology. --- Toxicology. --- Internal medicine. --- Endocrinology. --- Cytology. --- Pharmacology/Toxicology. --- Internal Medicine. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Internal medicine --- Hormones --- Medicine, Internal --- Medicine --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Immunobiology --- Life sciences --- Serology --- Toxicology --- Pharmacology. --- Endocrinology . --- Cell biology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

When you go to the pharmacy and fill a prescription, have you ever wondered if the dose of the medication is right for you? Can the dose be too low so that the drug will not work? Can the dose be too high that it may cause some potential problem? How do people learn about dosing information? This book answers some of these questions. Dosing information on the drug label is based on discussion and agreement between the pharmaceutical manufacturer and the drug regulatory agency. A drug label is a high level summary of results obtained from many scientific experiments. Scientists with biological, chemical, medical, or statistical background working in the pharmaceutical industry designed and executed these experiments to obtain information to help understand the dosing information. This book introduces the drug development process, the design and analysis of clinical trials. Many of the discussions are based on applications of statistical methods in the design and analysis of dose response studies. Although the book is prepared mainly for statisticians/biostatisticians, it also serves as a useful reference to a variety of professionals working for the pharmaceutical industry. The potential readers include pharmacokienticists, clinical scientists, clinical pharmacologists, pharmacists, project managers, pharmaceutical scientists, clinicians, programmers, data managers, regulatory specialists, and study report writers. This book is also a good reference for professionals working in a drug regulatory environment, for example, the FDA. Scientists and/or reviewers from both U.S. and foreign drug regulatory agencies can benefit greatly from this book. In addition, statistical and medical professionals in academia may find this book helpful in understanding the drug development process and practical concerns in selecting doses for a new drug. Naitee Ting received his Ph. D. in statistics from Colorado State University in 1987 and joined Pfizer Research right after obtaining his Ph. D. Dr. Ting is currently an Associate Director of Biostatistics in Pfizer Global Research and Development, supporting clinical development of new drugs. He has over 18 years of experiences in designing and analyzing late phase clinical trials. During his tenure at Pfizer, Dr. Ting has published more than 20 statistical papers in peer-reviewed journals and book chapters. He has also taught clinical trials courses at the University of Connecticut and University of Rhode Island.

Drugs --- Drug development. --- Dose-response relationship --- Mathematics. --- Development of drugs --- New drug development --- Pharmacology --- Pharmacy --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Development --- Biomathematics. Biometry. Biostatistics --- Mathematical statistics --- Toxicology. --- Statistics. --- Pharmacology/Toxicology. --- Statistics for Life Sciences, Medicine, Health Sciences. --- Statistical analysis --- Statistical data --- Statistical methods --- Statistical science --- Mathematics --- Econometrics --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Statistics . --- Drug effects --- Medical pharmacology --- Medical sciences --- Physiological effect

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nature Reviews Drug Discovery integrates academia and industry, providing broad, expert coverage of the whole drug discovery and development arena – from disease mechanisms, novel therapeutic approaches and chemistry to clinical trials and regulatory affairs. All reviews are carefully commissioned, written by leaders in the field and subject to rigorous peer-review so that readers receive independent, high-quality and authoritative articles in each issue. Reviews are complemented by news stories that investigate the key issues in drug discovery, timely summaries of significant published papers, market analysis, and updates on the latest advances in fast-moving areas such as new technologies, drug approvals and patent law. Information is presented at several levels that can be tailored to users’ individual needs. Non-specialists will benefit from the glossary and highlighted references, and experts will appreciate the insight provided by top names in their field. Nature Reviews Drug Discovery is a major teaching and reference resource from NPG.

Pharmaceutical Preparations --- Research --- Drugs --- Pharmaceutical chemistry --- Médicaments --- Chimie pharmaceutique --- Periodicals. --- Design --- Recherche --- Périodiques --- Conception --- Pharmaceutical Preparations. --- Review Literature. --- Research. --- Pharmaceutical chemistry. --- Design. --- Chemistry --- Health Sciences --- Law --- Medicinal Chemistry --- Pharmaceutical Chemistry --- Synthesis --- Pharmacy and Pharmacology --- Therapeutics --- Intellectual Property --- Pharmacology. Therapy --- Pharmacology. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Drug Dosage Calculations --- Drug design --- Pharmaceutical design --- Drug development --- farmacologie --- Medicine --- Cancer research --- Molecular biology --- Biotechnology --- Biomedicine, general --- Pharmacology/Toxicology --- Molecular Medicine --- Cancer Research --- Chemical engineering --- Genetic engineering --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Health Workforce --- Physiological effect --- Drug --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Product, Pharmaceutical --- Pharmacy, Therapeutics, & Pharmacology --- Industrie pharmaceutique. --- Mensuels. --- Médicaments. --- Produits pharmaceutiques.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The G protein-coupled receptors (GPCRs), known to be one of the largest superfamilies in the human genome, underpin a multitude of physiological processes and represent a significant target for bioactive and drug discovery programs. In G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, experts in the field provide a range of classic and cutting-edge laboratory protocols developed for GPCR research, as well as several current review articles relevant to the area of high throughput GPCR screening, with discussion on GPCR structure and GPCR signalling. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols serves to aid all those who wish to further the vital research in their GPCR drug discovery programs.

Molecular biology --- Computational Biology. --- Sequence Analysis, DNA. --- Base Sequence. --- Sequence Analysis, RNA. --- Genetics --- Bioinformatics. --- Nucleotide sequence. --- Amino acid sequence. --- Génétique --- Bio-informatique --- Séquence nucléotidique --- Séquence des acides aminés --- Data processing. --- Informatique --- Bioinformatics --- Amino acid sequence --- Data processing --- -Nucleotide sequence --- #TELE:SISTA --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Nucleic acids --- Nucleotides --- Sequence alignment (Bioinformatics) --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Amino acid sequence analysis --- Analysis, Amino acid sequence --- Peptide sequence --- Peptide sequencing --- Protein sequence --- Protein sequencing --- Sequence, Amino acid --- Amino acids --- Proteins --- Analysis --- Génétique --- Séquence nucléotidique --- Séquence des acides aminés --- Nucleotide sequence --- 57.087 --- 57.087 Methods and techniques for parameter estimation. Recording of biological data --- Methods and techniques for parameter estimation. Recording of biological data --- G proteins --- Drug development --- Receptors, G-Protein-Coupled --- Drug Discovery --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Drug Prospecting --- Discovery, Drug --- Prospecting, Drug --- High-Throughput Screening Assays --- Bioprospecting --- G Protein Coupled Receptor --- G-Protein-Coupled Receptor --- G-Protein-Coupled Receptors --- G Protein Coupled Receptors --- Receptor, G-Protein-Coupled --- Receptors, G Protein Coupled --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Membrane proteins --- Receptors --- Development --- Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Genetics - Data processing